Synergistic activity between statins and bisphosphonates against acute experimental toxoplasmosis

Bisphosphonates are widely used for the treatment of bone disorders. These drugs also inhibit the growth of a variety of protozoan parasites, such as Toxoplasma gondii, the etiologic agent of toxoplasmosis. The target of the most potent bisphosphonates is the isoprenoid biosynthesis pathway enzyme f...

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Detalles Bibliográficos
Autores principales:	Li, Z.-H., Li, C., Szajnman, S.H., Rodriguez, J.B., Moreno, S.N.J.
Formato:	JOUR
Materias:	Bisphosphonate Isoprenoids Statins Synergy Toxoplasma gondii 1 [(n heptylthio)ethyl] 1,1 bisphosphonate alendronic acid antiprotozoal agent atorvastatin atovaquone bisphosphonic acid derivative cerivastatin compactin farnesyl diphosphate geranylgeranyl pyrophosphate hydroxymethylglutaryl coenzyme A reductase inhibitor mevinolin phytoene synthase pitavastatin risedronic acid simvastatin unclassified drug zoledronic acid 3-hydroxy-3-methylglutaryl-coenzyme A acyl coenzyme A geranyltransferase hydroxymethylglutaryl coenzyme A reductase imidazole derivative isoprenoid phosphate sesquiterpene animal experiment animal model Article controlled study dose response drug cytotoxicity drug dose drug potentiation EC50 human human cell IC50 in vitro study in vivo study infection prevention low drug dose mouse murine toxoplasmosis nonhuman priority journal animal antagonists and inhibitors biosynthesis cell line drug effects genetics growth, development and aging metabolism Toxoplasma toxoplasmosis Acyl Coenzyme A Animals Antiprotozoal Agents Atorvastatin Calcium Cell Line Diphosphonates Geranylgeranyl-Diphosphate Geranylgeranyltransferase Geranyltranstransferase Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Reductase Inhibitors Imidazoles Mice Polyisoprenyl Phosphates Sesquiterpenes Toxoplasmosis
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00664804_v61_n8_p_Li
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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