Coupling transcription and alternative splicing.

Alternative splicing regulation not only depends on the interaction of splicing factors with splicing enhancers and silencers in the pre-mRNA, but also on the coupling between transcription and splicing. This coupling is possible because splicing is often cotranscriptional and promoter identity and...

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Autor principal:	Kornblihtt, A.R.
Formato:	JOUR
Materias:	RNA polymerase II alternative RNA splicing animal chromatin genetic transcription genetics human metabolism physiology review Alternative Splicing Animals Chromatin Humans RNA Polymerase II Transcription, Genetic
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00652598_v623_n_p175_Kornblihtt
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00652598_v623_n_p175_Kornblihtt
record_format	dspace
spelling	todo:paper_00652598_v623_n_p175_Kornblihtt2023-10-03T14:52:55Z Coupling transcription and alternative splicing. Kornblihtt, A.R. RNA polymerase II alternative RNA splicing animal chromatin genetic transcription genetics human metabolism physiology review Alternative Splicing Animals Chromatin Humans RNA Polymerase II Transcription, Genetic Alternative splicing regulation not only depends on the interaction of splicing factors with splicing enhancers and silencers in the pre-mRNA, but also on the coupling between transcription and splicing. This coupling is possible because splicing is often cotranscriptional and promoter identity and occupation may affect alternative splicing. We discuss here the different mechanisms by which transcription regulates alternative splicing. These include the recruitment of splicing factors to the transcribing polymerase and "kinetic coupling", which involves changes in the rate of transcriptional elongation that in turn affect the timing in which splice sites are presented to the splicing machinery. The recruitment mechanism may depend on the particular features of the carboxyl terminal domain of RNA polymerase II, whereas kinetic coupling seems to be linked to how changes in chromatin structure and other factors affect transcription elongation. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00652598_v623_n_p175_Kornblihtt
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	RNA polymerase II alternative RNA splicing animal chromatin genetic transcription genetics human metabolism physiology review Alternative Splicing Animals Chromatin Humans RNA Polymerase II Transcription, Genetic
spellingShingle	RNA polymerase II alternative RNA splicing animal chromatin genetic transcription genetics human metabolism physiology review Alternative Splicing Animals Chromatin Humans RNA Polymerase II Transcription, Genetic Kornblihtt, A.R. Coupling transcription and alternative splicing.
topic_facet	RNA polymerase II alternative RNA splicing animal chromatin genetic transcription genetics human metabolism physiology review Alternative Splicing Animals Chromatin Humans RNA Polymerase II Transcription, Genetic
description	Alternative splicing regulation not only depends on the interaction of splicing factors with splicing enhancers and silencers in the pre-mRNA, but also on the coupling between transcription and splicing. This coupling is possible because splicing is often cotranscriptional and promoter identity and occupation may affect alternative splicing. We discuss here the different mechanisms by which transcription regulates alternative splicing. These include the recruitment of splicing factors to the transcribing polymerase and "kinetic coupling", which involves changes in the rate of transcriptional elongation that in turn affect the timing in which splice sites are presented to the splicing machinery. The recruitment mechanism may depend on the particular features of the carboxyl terminal domain of RNA polymerase II, whereas kinetic coupling seems to be linked to how changes in chromatin structure and other factors affect transcription elongation.
format	JOUR
author	Kornblihtt, A.R.
author_facet	Kornblihtt, A.R.
author_sort	Kornblihtt, A.R.
title	Coupling transcription and alternative splicing.
title_short	Coupling transcription and alternative splicing.
title_full	Coupling transcription and alternative splicing.
title_fullStr	Coupling transcription and alternative splicing.
title_full_unstemmed	Coupling transcription and alternative splicing.
title_sort	coupling transcription and alternative splicing.
url	http://hdl.handle.net/20.500.12110/paper_00652598_v623_n_p175_Kornblihtt
work_keys_str_mv	AT kornblihttar couplingtranscriptionandalternativesplicing
_version_	1807319089094328320

Coupling transcription and alternative splicing.

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