The influence of sex and different segments of thoracic aorta on bioactive aortic substance (BAS) and prostacyclin (PGI2) synthesis

BAS is a protein generated by aortic rings isolated from rats. Our previous results clearly established that BAS inhibits platelet aggregation and modifies vascular tone. We have now examined the effect of separated segments of thoracic aorta and the effect of sex on the release of the BAS and PGI2....

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Detalles Bibliográficos
Autores principales: Maugeri, N., Bermejo, E., Faletti, A., Schattner, M.A., Chaud, M., Gimeno, M.F., Lazzari, M.A.
Formato: JOUR
Materias:
biological aortic substance
prostacyclin
segment of aorta
sex
thrombocyte aggregation inhibitor
animal cell
aorta arch
female
male
nonhuman
priority journal
prostaglandin synthesis
protein secretion
rat
thoracic aorta
Animal
Aorta, Thoracic
Epoprostenol
Female
Human
In Vitro
Male
Platelet Aggregation Inhibitors
Proteins
Rats
Rats, Inbred Strains
Sex Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00493848_v56_n1_p19_Maugeri
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:BAS is a protein generated by aortic rings isolated from rats. Our previous results clearly established that BAS inhibits platelet aggregation and modifies vascular tone. We have now examined the effect of separated segments of thoracic aorta and the effect of sex on the release of the BAS and PGI2. We evaluated three different segments of thoracic aorta: A= aortic arch, B= the upper segment and C= the lowest segment of the thoracic aorta. We measured the release of BAS and PGI2 from them. The BAS production increased in the first segment (A) when compared with the other two (B and C), whilst PGI2 production was the same along the thoracic aorta. On the other hand female and male thoracic aorta produced the same levels of BAS and 6-keto PGF1α. © 1989.

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