The influence of sex and different segments of thoracic aorta on bioactive aortic substance (BAS) and prostacyclin (PGI2) synthesis

BAS is a protein generated by aortic rings isolated from rats. Our previous results clearly established that BAS inhibits platelet aggregation and modifies vascular tone. We have now examined the effect of separated segments of thoracic aorta and the effect of sex on the release of the BAS and PGI2....

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Maugeri, N., Bermejo, E., Faletti, A., Schattner, M.A., Chaud, M., Gimeno, M.F., Lazzari, M.A.
Formato: JOUR
Materias:
biological aortic substance
prostacyclin
segment of aorta
sex
thrombocyte aggregation inhibitor
animal cell
aorta arch
female
male
nonhuman
priority journal
prostaglandin synthesis
protein secretion
rat
thoracic aorta
Animal
Aorta, Thoracic
Epoprostenol
Female
Human
In Vitro
Male
Platelet Aggregation Inhibitors
Proteins
Rats
Rats, Inbred Strains
Sex Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00493848_v56_n1_p19_Maugeri
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00493848_v56_n1_p19_Maugeri
record_format dspace
spelling todo:paper_00493848_v56_n1_p19_Maugeri2023-10-03T14:52:41Z The influence of sex and different segments of thoracic aorta on bioactive aortic substance (BAS) and prostacyclin (PGI2) synthesis Maugeri, N. Bermejo, E. Faletti, A. Schattner, M.A. Chaud, M. Gimeno, M.F. Lazzari, M.A. biological aortic substance prostacyclin segment of aorta sex prostacyclin thrombocyte aggregation inhibitor animal cell aorta arch female male nonhuman priority journal prostaglandin synthesis protein secretion rat sex thoracic aorta Animal Aorta, Thoracic Epoprostenol Female Human In Vitro Male Platelet Aggregation Inhibitors Proteins Rats Rats, Inbred Strains Sex Factors BAS is a protein generated by aortic rings isolated from rats. Our previous results clearly established that BAS inhibits platelet aggregation and modifies vascular tone. We have now examined the effect of separated segments of thoracic aorta and the effect of sex on the release of the BAS and PGI2. We evaluated three different segments of thoracic aorta: A= aortic arch, B= the upper segment and C= the lowest segment of the thoracic aorta. We measured the release of BAS and PGI2 from them. The BAS production increased in the first segment (A) when compared with the other two (B and C), whilst PGI2 production was the same along the thoracic aorta. On the other hand female and male thoracic aorta produced the same levels of BAS and 6-keto PGF1α. © 1989. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00493848_v56_n1_p19_Maugeri
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic biological aortic substance
prostacyclin
segment of aorta
sex
prostacyclin
thrombocyte aggregation inhibitor
animal cell
aorta arch
female
male
nonhuman
priority journal
prostaglandin synthesis
protein secretion
rat
sex
thoracic aorta
Animal
Aorta, Thoracic
Epoprostenol
Female
Human
In Vitro
Male
Platelet Aggregation Inhibitors
Proteins
Rats
Rats, Inbred Strains
Sex Factors
spellingShingle biological aortic substance
prostacyclin
segment of aorta
sex
prostacyclin
thrombocyte aggregation inhibitor
animal cell
aorta arch
female
male
nonhuman
priority journal
prostaglandin synthesis
protein secretion
rat
sex
thoracic aorta
Animal
Aorta, Thoracic
Epoprostenol
Female
Human
In Vitro
Male
Platelet Aggregation Inhibitors
Proteins
Rats
Rats, Inbred Strains
Sex Factors
Maugeri, N.
Bermejo, E.
Faletti, A.
Schattner, M.A.
Chaud, M.
Gimeno, M.F.
Lazzari, M.A.
The influence of sex and different segments of thoracic aorta on bioactive aortic substance (BAS) and prostacyclin (PGI2) synthesis
topic_facet biological aortic substance
prostacyclin
segment of aorta
sex
prostacyclin
thrombocyte aggregation inhibitor
animal cell
aorta arch
female
male
nonhuman
priority journal
prostaglandin synthesis
protein secretion
rat
sex
thoracic aorta
Animal
Aorta, Thoracic
Epoprostenol
Female
Human
In Vitro
Male
Platelet Aggregation Inhibitors
Proteins
Rats
Rats, Inbred Strains
Sex Factors
description BAS is a protein generated by aortic rings isolated from rats. Our previous results clearly established that BAS inhibits platelet aggregation and modifies vascular tone. We have now examined the effect of separated segments of thoracic aorta and the effect of sex on the release of the BAS and PGI2. We evaluated three different segments of thoracic aorta: A= aortic arch, B= the upper segment and C= the lowest segment of the thoracic aorta. We measured the release of BAS and PGI2 from them. The BAS production increased in the first segment (A) when compared with the other two (B and C), whilst PGI2 production was the same along the thoracic aorta. On the other hand female and male thoracic aorta produced the same levels of BAS and 6-keto PGF1α. © 1989.
format JOUR
author Maugeri, N.
Bermejo, E.
Faletti, A.
Schattner, M.A.
Chaud, M.
Gimeno, M.F.
Lazzari, M.A.
author_facet Maugeri, N.
Bermejo, E.
Faletti, A.
Schattner, M.A.
Chaud, M.
Gimeno, M.F.
Lazzari, M.A.
author_sort Maugeri, N.
title The influence of sex and different segments of thoracic aorta on bioactive aortic substance (BAS) and prostacyclin (PGI2) synthesis
title_short The influence of sex and different segments of thoracic aorta on bioactive aortic substance (BAS) and prostacyclin (PGI2) synthesis
title_full The influence of sex and different segments of thoracic aorta on bioactive aortic substance (BAS) and prostacyclin (PGI2) synthesis
title_fullStr The influence of sex and different segments of thoracic aorta on bioactive aortic substance (BAS) and prostacyclin (PGI2) synthesis
title_full_unstemmed The influence of sex and different segments of thoracic aorta on bioactive aortic substance (BAS) and prostacyclin (PGI2) synthesis
title_sort influence of sex and different segments of thoracic aorta on bioactive aortic substance (bas) and prostacyclin (pgi2) synthesis
url http://hdl.handle.net/20.500.12110/paper_00493848_v56_n1_p19_Maugeri
work_keys_str_mv AT maugerin theinfluenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT bermejoe theinfluenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT falettia theinfluenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT schattnerma theinfluenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT chaudm theinfluenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT gimenomf theinfluenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT lazzarima theinfluenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT maugerin influenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT bermejoe influenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT falettia influenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT schattnerma influenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT chaudm influenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT gimenomf influenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
AT lazzarima influenceofsexanddifferentsegmentsofthoracicaortaonbioactiveaorticsubstancebasandprostacyclinpgi2synthesis
_version_ 1807314829607698432

Ejemplares similares