Platelet function and antithrombins in hyperlipoproteinemia type IIa
Platelet function was studied in 35 patients with type IIa hyperlipoproteinemia and 22 normal controls. Platelet aggregation by ADP in concentrations ranging from 2×10-6 to 2×10-5 M, and adrenaline 10-6 M were similar in both groups. In contrast, aggregation induced by collagen and secondary aggrega...
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todo:paper_00493848_v22_n4_p427_Molinas2023-10-03T14:52:38Z Platelet function and antithrombins in hyperlipoproteinemia type IIa Molinas, F.C. Drucker, E. Kordich, L. Alvarez Reynolds, M. Finkielman, S. antithrombins hyperlipoproteinemia platelet aggregation antithrombin cholesterol heparin blood and hemopoietic system etiology human cell hyperlipoproteinemia type 2a in vitro study thrombocyte aggregation Adenosine Diphosphate Adult Antithrombins Blood Coagulation Blood Platelets Calcium Cholesterol Epinephrine Female Heparin Antagonists Humans Hyperlipoproteinemia Type II Male Middle Aged Platelet Aggregation Thromboplastin Platelet function was studied in 35 patients with type IIa hyperlipoproteinemia and 22 normal controls. Platelet aggregation by ADP in concentrations ranging from 2×10-6 to 2×10-5 M, and adrenaline 10-6 M were similar in both groups. In contrast, aggregation induced by collagen and secondary aggregation elicited by bovine factor VIII were significantly lower in hypercholesterolemic patients, who also disclosed an increased plasmatic antiheparin activity. This plasmatic antiheparin activity was inversely correlated to plasmatic cholesterol concentration, (r = -0.50, p<0.01). PF3 and PF4 were normal in patients with type IIa hyperlipoproteinemia. AntiFXa, antithrombin III, and heparin cofactor were also determined. Heparin cofactor was found to be significantly lower in hypercholesterolemic patients than in controls, and inversely correlated to plasmatic cholesterol concentration (r = -0.51, p<0.05). These observations suggest that the thrombotic tendency in hypercholesterolemia may be related to a decrease of plasmatic heparin cofactor. © 1981. Fil:Kordich, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00493848_v22_n4_p427_Molinas |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
antithrombins hyperlipoproteinemia platelet aggregation antithrombin cholesterol heparin blood and hemopoietic system etiology human cell hyperlipoproteinemia type 2a in vitro study thrombocyte aggregation Adenosine Diphosphate Adult Antithrombins Blood Coagulation Blood Platelets Calcium Cholesterol Epinephrine Female Heparin Antagonists Humans Hyperlipoproteinemia Type II Male Middle Aged Platelet Aggregation Thromboplastin |
| spellingShingle |
antithrombins hyperlipoproteinemia platelet aggregation antithrombin cholesterol heparin blood and hemopoietic system etiology human cell hyperlipoproteinemia type 2a in vitro study thrombocyte aggregation Adenosine Diphosphate Adult Antithrombins Blood Coagulation Blood Platelets Calcium Cholesterol Epinephrine Female Heparin Antagonists Humans Hyperlipoproteinemia Type II Male Middle Aged Platelet Aggregation Thromboplastin Molinas, F.C. Drucker, E. Kordich, L. Alvarez Reynolds, M. Finkielman, S. Platelet function and antithrombins in hyperlipoproteinemia type IIa |
| topic_facet |
antithrombins hyperlipoproteinemia platelet aggregation antithrombin cholesterol heparin blood and hemopoietic system etiology human cell hyperlipoproteinemia type 2a in vitro study thrombocyte aggregation Adenosine Diphosphate Adult Antithrombins Blood Coagulation Blood Platelets Calcium Cholesterol Epinephrine Female Heparin Antagonists Humans Hyperlipoproteinemia Type II Male Middle Aged Platelet Aggregation Thromboplastin |
| description |
Platelet function was studied in 35 patients with type IIa hyperlipoproteinemia and 22 normal controls. Platelet aggregation by ADP in concentrations ranging from 2×10-6 to 2×10-5 M, and adrenaline 10-6 M were similar in both groups. In contrast, aggregation induced by collagen and secondary aggregation elicited by bovine factor VIII were significantly lower in hypercholesterolemic patients, who also disclosed an increased plasmatic antiheparin activity. This plasmatic antiheparin activity was inversely correlated to plasmatic cholesterol concentration, (r = -0.50, p<0.01). PF3 and PF4 were normal in patients with type IIa hyperlipoproteinemia. AntiFXa, antithrombin III, and heparin cofactor were also determined. Heparin cofactor was found to be significantly lower in hypercholesterolemic patients than in controls, and inversely correlated to plasmatic cholesterol concentration (r = -0.51, p<0.05). These observations suggest that the thrombotic tendency in hypercholesterolemia may be related to a decrease of plasmatic heparin cofactor. © 1981. |
| format |
JOUR |
| author |
Molinas, F.C. Drucker, E. Kordich, L. Alvarez Reynolds, M. Finkielman, S. |
| author_facet |
Molinas, F.C. Drucker, E. Kordich, L. Alvarez Reynolds, M. Finkielman, S. |
| author_sort |
Molinas, F.C. |
| title |
Platelet function and antithrombins in hyperlipoproteinemia type IIa |
| title_short |
Platelet function and antithrombins in hyperlipoproteinemia type IIa |
| title_full |
Platelet function and antithrombins in hyperlipoproteinemia type IIa |
| title_fullStr |
Platelet function and antithrombins in hyperlipoproteinemia type IIa |
| title_full_unstemmed |
Platelet function and antithrombins in hyperlipoproteinemia type IIa |
| title_sort |
platelet function and antithrombins in hyperlipoproteinemia type iia |
| url |
http://hdl.handle.net/20.500.12110/paper_00493848_v22_n4_p427_Molinas |
| work_keys_str_mv |
AT molinasfc plateletfunctionandantithrombinsinhyperlipoproteinemiatypeiia AT druckere plateletfunctionandantithrombinsinhyperlipoproteinemiatypeiia AT kordichl plateletfunctionandantithrombinsinhyperlipoproteinemiatypeiia AT alvarezreynoldsm plateletfunctionandantithrombinsinhyperlipoproteinemiatypeiia AT finkielmans plateletfunctionandantithrombinsinhyperlipoproteinemiatypeiia |
| _version_ |
1807322220042649600 |