Comparative toxicity of two glyphosate-based formulations to Eisenia andrei under laboratory conditions
Glyphosate-based products are the leading post-emergent agricultural herbicides in the world, particularly in association with glyphosate tolerant crops. However, studies on the effects of glyphosate-based formulations on terrestrial receptors are scarce. This study was conducted to evaluate the com...
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todo:paper_00456535_v91_n4_p545_Piola2023-10-03T14:52:03Z Comparative toxicity of two glyphosate-based formulations to Eisenia andrei under laboratory conditions Piola, L. Fuchs, J. Oneto, M.L. Basack, S. Kesten, E. Casabé, N. Comet assay Eisenia andrei Glyphosate formulations Neutral red retention time Sublethal biomarkers Comet assays Ecotoxicological assessment Eisenia andrei Environmental concentration Glyphosates Median Lethal concentration Oxidative phosphorylation Retention time Agriculture Biochemistry Toxicity Herbicides ammonium derivative glyphosate agricultural practice bioavailability biomarker comparative study concentration (composition) dose-response relationship earthworm ecotoxicology glyphosate laboratory method pollution effect toxicity test weight article bioaccumulation bioavailability cell damage comet assay comparative study controlled study DNA damage earthworm Eisenia andrei growth LC 50 lysosome nonhuman oxidative phosphorylation toxicity weight reduction Animals Glycine Herbicides Laboratories Lethal Dose 50 Oligochaeta Risk Assessment Soil Pollutants Eisenia andrei Glyphosate-based products are the leading post-emergent agricultural herbicides in the world, particularly in association with glyphosate tolerant crops. However, studies on the effects of glyphosate-based formulations on terrestrial receptors are scarce. This study was conducted to evaluate the comparative toxicity of two glyphosate-based products: Roundup FG (monoammonium salt, 72% acid equivalent, glyphosate-A) and Mon 8750 (monoammonium salt, 85.4% acid equivalent, glyphosate-B), towards the earthworm Eisenia andrei. Median lethal concentration (LC50) showed that glyphosate-A was 4.5-fold more toxic than glyphosate-B. Sublethal concentrations caused a concentration-dependent weight loss, consistent with the reported effect of glyphosate as uncoupler of oxidative phosphorylation. Glyphosate-A showed deleterious effects on DNA and lysosomal damage at concentrations close to the applied environmental concentrations (14.4μg ae cm-2). With glyphosate-B toxic effects were observed at higher doses, close to its LC50, suggesting that the higher toxicity of formulate A could be attributed to the effects of some of the so-called "inert ingredients", either due to a direct intrinsic toxicity, or to an enhancement in the bioavailability and/or bioaccumulation of the active ingredient. Our results highlight the importance of ecotoxicological assessment not only of the active ingredients, but also of the different formulations usually employed in agricultural practices. © 2012 Elsevier Ltd. Fil:Piola, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kesten, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Casabé, N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00456535_v91_n4_p545_Piola |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Comet assay Eisenia andrei Glyphosate formulations Neutral red retention time Sublethal biomarkers Comet assays Ecotoxicological assessment Eisenia andrei Environmental concentration Glyphosates Median Lethal concentration Oxidative phosphorylation Retention time Agriculture Biochemistry Toxicity Herbicides ammonium derivative glyphosate agricultural practice bioavailability biomarker comparative study concentration (composition) dose-response relationship earthworm ecotoxicology glyphosate laboratory method pollution effect toxicity test weight article bioaccumulation bioavailability cell damage comet assay comparative study controlled study DNA damage earthworm Eisenia andrei growth LC 50 lysosome nonhuman oxidative phosphorylation toxicity weight reduction Animals Glycine Herbicides Laboratories Lethal Dose 50 Oligochaeta Risk Assessment Soil Pollutants Eisenia andrei |
| spellingShingle |
Comet assay Eisenia andrei Glyphosate formulations Neutral red retention time Sublethal biomarkers Comet assays Ecotoxicological assessment Eisenia andrei Environmental concentration Glyphosates Median Lethal concentration Oxidative phosphorylation Retention time Agriculture Biochemistry Toxicity Herbicides ammonium derivative glyphosate agricultural practice bioavailability biomarker comparative study concentration (composition) dose-response relationship earthworm ecotoxicology glyphosate laboratory method pollution effect toxicity test weight article bioaccumulation bioavailability cell damage comet assay comparative study controlled study DNA damage earthworm Eisenia andrei growth LC 50 lysosome nonhuman oxidative phosphorylation toxicity weight reduction Animals Glycine Herbicides Laboratories Lethal Dose 50 Oligochaeta Risk Assessment Soil Pollutants Eisenia andrei Piola, L. Fuchs, J. Oneto, M.L. Basack, S. Kesten, E. Casabé, N. Comparative toxicity of two glyphosate-based formulations to Eisenia andrei under laboratory conditions |
| topic_facet |
Comet assay Eisenia andrei Glyphosate formulations Neutral red retention time Sublethal biomarkers Comet assays Ecotoxicological assessment Eisenia andrei Environmental concentration Glyphosates Median Lethal concentration Oxidative phosphorylation Retention time Agriculture Biochemistry Toxicity Herbicides ammonium derivative glyphosate agricultural practice bioavailability biomarker comparative study concentration (composition) dose-response relationship earthworm ecotoxicology glyphosate laboratory method pollution effect toxicity test weight article bioaccumulation bioavailability cell damage comet assay comparative study controlled study DNA damage earthworm Eisenia andrei growth LC 50 lysosome nonhuman oxidative phosphorylation toxicity weight reduction Animals Glycine Herbicides Laboratories Lethal Dose 50 Oligochaeta Risk Assessment Soil Pollutants Eisenia andrei |
| description |
Glyphosate-based products are the leading post-emergent agricultural herbicides in the world, particularly in association with glyphosate tolerant crops. However, studies on the effects of glyphosate-based formulations on terrestrial receptors are scarce. This study was conducted to evaluate the comparative toxicity of two glyphosate-based products: Roundup FG (monoammonium salt, 72% acid equivalent, glyphosate-A) and Mon 8750 (monoammonium salt, 85.4% acid equivalent, glyphosate-B), towards the earthworm Eisenia andrei. Median lethal concentration (LC50) showed that glyphosate-A was 4.5-fold more toxic than glyphosate-B. Sublethal concentrations caused a concentration-dependent weight loss, consistent with the reported effect of glyphosate as uncoupler of oxidative phosphorylation. Glyphosate-A showed deleterious effects on DNA and lysosomal damage at concentrations close to the applied environmental concentrations (14.4μg ae cm-2). With glyphosate-B toxic effects were observed at higher doses, close to its LC50, suggesting that the higher toxicity of formulate A could be attributed to the effects of some of the so-called "inert ingredients", either due to a direct intrinsic toxicity, or to an enhancement in the bioavailability and/or bioaccumulation of the active ingredient. Our results highlight the importance of ecotoxicological assessment not only of the active ingredients, but also of the different formulations usually employed in agricultural practices. © 2012 Elsevier Ltd. |
| format |
JOUR |
| author |
Piola, L. Fuchs, J. Oneto, M.L. Basack, S. Kesten, E. Casabé, N. |
| author_facet |
Piola, L. Fuchs, J. Oneto, M.L. Basack, S. Kesten, E. Casabé, N. |
| author_sort |
Piola, L. |
| title |
Comparative toxicity of two glyphosate-based formulations to Eisenia andrei under laboratory conditions |
| title_short |
Comparative toxicity of two glyphosate-based formulations to Eisenia andrei under laboratory conditions |
| title_full |
Comparative toxicity of two glyphosate-based formulations to Eisenia andrei under laboratory conditions |
| title_fullStr |
Comparative toxicity of two glyphosate-based formulations to Eisenia andrei under laboratory conditions |
| title_full_unstemmed |
Comparative toxicity of two glyphosate-based formulations to Eisenia andrei under laboratory conditions |
| title_sort |
comparative toxicity of two glyphosate-based formulations to eisenia andrei under laboratory conditions |
| url |
http://hdl.handle.net/20.500.12110/paper_00456535_v91_n4_p545_Piola |
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