A facile synthesis of 3-glycosyl-5-substituted-2-isoxazoles

The 1,3-dipolar cycloaddition reaction between a 2-deoxy-D-aldose oxime (D-gluco or D-ribo) and an alkyne as dipolarophile (phenylacetylene, 2-propyn-1-o1, 3-chloro-1-propyne, or 3-bromo-1-propyne) is described. The new 3-glycosyl-5-substituted-2-isoxazoles are characterized physically and spectrosc...

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Detalles Bibliográficos
Autores principales: Fascio, M.L., D'Accorso, N.B.
Formato: JOUR
Materias:
2 isoxazole derivative
alkyne
isoxazole derivative
oxime
unclassified drug
article
cyclization
drug synthesis
reaction analysis
spectroscopy
stereochemistry
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00397911_v31_n12_p1913_Fascio
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The 1,3-dipolar cycloaddition reaction between a 2-deoxy-D-aldose oxime (D-gluco or D-ribo) and an alkyne as dipolarophile (phenylacetylene, 2-propyn-1-o1, 3-chloro-1-propyne, or 3-bromo-1-propyne) is described. The new 3-glycosyl-5-substituted-2-isoxazoles are characterized physically and spectroscopically.

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