Multicomponent synthesis of 4,4-dimethyl sterol analogues and their effect on eukaryotic cells

Most sterols, such as cholesterol and ergosterol, become functional only after the removal of the two methyl groups at C-4 from their biosynthetic precursors. Nevertheless, some findings suggest that 4,4-dimethyl sterols might be involved in specific physiological processes. In this paper we present...

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Autores principales:	Alonso, F., Cirigliano, A.M., Dávola, M.E., Cabrera, G.M., García Liñares, G.E., Labriola, C., Barquero, A.A., Ramírez, J.A.
Formato:	JOUR
Materias:	4,4-Dimethyl sterols Antifungal Cytotoxic Keywords Ugi reaction (17beta) 4,4 dimethyl 3 oxoandrost 5 ene 17 carboxylate (17beta) 4,4 dimethyl 3 oxoandrost 5 ene 17 carboxylic acid (17beta) n ((t butylcarbamoyl)methyl) n (2 chlorophenyl) 4,4 dimethyl 3 hydroxyandrost 5 ene 17 carboxamide (17beta) n ((t butylcarbamoyl)methyl) n (2 ethyl 6 methylphenyl) 4,4 dimethyl 3 oxoandrost 5 ene 17 carboxamide (17beta) n ((t butylcarbamoyl)methyl) n (2 fluorophenyl) 4,4 dimethyl 3 oxoandrost 5 ene 17 carboxamide (17beta) n ((t butylcarbamoyl)methyl) n (2 naphthyl) 4,4 dimethyl 3 oxoandrost 5 ene 17 carboxamide (17beta) n ((t butylcarbamoyl)methyl) n (4 chlorophenyl) 4,4 dimethyl 3 hydroxyandrost 5 ene 17 carboxamide (17beta) n ((t butylcarbamoyl)methyl) n (4 chlorophenyl) 4,4 dimethyl 3 oxoandrost 5 ene 17 carboxamide (17beta) n ((t butylcarbamoyl)methyl) n (4 fluorophenyl) 4,4 dimethyl 3 hydroxyandrost 5 ene 17 carboxamide (17beta) n ((t butylcarbamoyl)methyl) n (4 fluorophenyl) 4,4 dimethyl 3 oxoandrost 5 ene 17 carboxamide (17beta) n ((t butylcarbamoyl)methyl) n (4 methoxyphenyl) 4,4 dimethyl 3 hydroxyandrost 5 ene 17 carboxamide (17beta) n ((t butylcarbamoyl)methyl) n (4 methoxyphenyl) 4,4 dimethyl 3 oxoandrost 5 ene 17 carboxamide (17beta) n ((t butylcarbamoyl)methyl) n (4 methylphenyl) 4,4 dimethyl 3 hydroxyandrost 5 ene 17 carboxamide (17beta) n ((t butylcarbamoyl)methyl) n phenyl 4,4 dimethyl 3 hydroxyandrost 5 ene 17 carboxamide (17beta) n ((t butylcarbamoyl)methyl) n phenyl 4,4 dimethyl 3 oxoandrost 5 ene 17 carboxamide 2 (t butylamino) 2 oxoethyl (17beta) 4,4 dimethyl 3 hydroxyandrost 5 ene 17 carboxylate antifungal agent sterol derivative unclassified drug sterol antifungal activity article broth dilution drug cytotoxicity drug synthesis eukaryotic cell Fusarium minimum inhibitory concentration nonhuman structure activity relation Trypanosoma cruzi animal biosynthesis chemistry Chlorocebus aethiops drug effects electrospray mass spectrometry human nuclear magnetic resonance spectroscopy Vero cell line Animals Cercopithecus aethiops Eukaryotic Cells Humans Magnetic Resonance Spectroscopy Spectrometry, Mass, Electrospray Ionization Sterols Vero Cells
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0039128X_v84_n_p1_Alonso
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires