Synthesis and biological activity of brassinosteroids fluorinated at C-2
In this paper we report the synthesis of four fluorinated analogues of brassinosteroids in which fluorine was introduced stereoselectively at C-2. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that two of these analogues elicit high bio...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0039128X_v74_n4-5_p435_Acebedo |
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todo:paper_0039128X_v74_n4-5_p435_Acebedo2023-10-03T14:49:28Z Synthesis and biological activity of brassinosteroids fluorinated at C-2 Acebedo, S.L. Ramírez, J.A. Galagovsky, L.R. Brassinosteroids Fluorinated steroids Oryza sativa 2alpha fluoro 3alpha,22,23 trihydroxy 5alpha stigmastan 6 one 2alpha fluoro 3beta,22,23 trihydroxy 5alpha stigmastan 6 one brassinosteroid carbon cell receptor fluorinated steroid hydrogen unclassified drug analytic method article biological activity chemical bond chemical interaction chemical structure fluorination germination hydrogen bond nonhuman plant growth rice seedling stereochemistry synthesis Biological Assay Cholestanols Halogenation Oryza sativa Steroids, Heterocyclic Oryza sativa In this paper we report the synthesis of four fluorinated analogues of brassinosteroids in which fluorine was introduced stereoselectively at C-2. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that two of these analogues elicit high bioactivity, suggesting the involvement of hydrogen bond interactions between the active brassinosteroids and their cellular receptor. © 2008 Elsevier Inc. All rights reserved. Fil:Acebedo, S.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ramírez, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0039128X_v74_n4-5_p435_Acebedo |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Brassinosteroids Fluorinated steroids Oryza sativa 2alpha fluoro 3alpha,22,23 trihydroxy 5alpha stigmastan 6 one 2alpha fluoro 3beta,22,23 trihydroxy 5alpha stigmastan 6 one brassinosteroid carbon cell receptor fluorinated steroid hydrogen unclassified drug analytic method article biological activity chemical bond chemical interaction chemical structure fluorination germination hydrogen bond nonhuman plant growth rice seedling stereochemistry synthesis Biological Assay Cholestanols Halogenation Oryza sativa Steroids, Heterocyclic Oryza sativa |
| spellingShingle |
Brassinosteroids Fluorinated steroids Oryza sativa 2alpha fluoro 3alpha,22,23 trihydroxy 5alpha stigmastan 6 one 2alpha fluoro 3beta,22,23 trihydroxy 5alpha stigmastan 6 one brassinosteroid carbon cell receptor fluorinated steroid hydrogen unclassified drug analytic method article biological activity chemical bond chemical interaction chemical structure fluorination germination hydrogen bond nonhuman plant growth rice seedling stereochemistry synthesis Biological Assay Cholestanols Halogenation Oryza sativa Steroids, Heterocyclic Oryza sativa Acebedo, S.L. Ramírez, J.A. Galagovsky, L.R. Synthesis and biological activity of brassinosteroids fluorinated at C-2 |
| topic_facet |
Brassinosteroids Fluorinated steroids Oryza sativa 2alpha fluoro 3alpha,22,23 trihydroxy 5alpha stigmastan 6 one 2alpha fluoro 3beta,22,23 trihydroxy 5alpha stigmastan 6 one brassinosteroid carbon cell receptor fluorinated steroid hydrogen unclassified drug analytic method article biological activity chemical bond chemical interaction chemical structure fluorination germination hydrogen bond nonhuman plant growth rice seedling stereochemistry synthesis Biological Assay Cholestanols Halogenation Oryza sativa Steroids, Heterocyclic Oryza sativa |
| description |
In this paper we report the synthesis of four fluorinated analogues of brassinosteroids in which fluorine was introduced stereoselectively at C-2. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that two of these analogues elicit high bioactivity, suggesting the involvement of hydrogen bond interactions between the active brassinosteroids and their cellular receptor. © 2008 Elsevier Inc. All rights reserved. |
| format |
JOUR |
| author |
Acebedo, S.L. Ramírez, J.A. Galagovsky, L.R. |
| author_facet |
Acebedo, S.L. Ramírez, J.A. Galagovsky, L.R. |
| author_sort |
Acebedo, S.L. |
| title |
Synthesis and biological activity of brassinosteroids fluorinated at C-2 |
| title_short |
Synthesis and biological activity of brassinosteroids fluorinated at C-2 |
| title_full |
Synthesis and biological activity of brassinosteroids fluorinated at C-2 |
| title_fullStr |
Synthesis and biological activity of brassinosteroids fluorinated at C-2 |
| title_full_unstemmed |
Synthesis and biological activity of brassinosteroids fluorinated at C-2 |
| title_sort |
synthesis and biological activity of brassinosteroids fluorinated at c-2 |
| url |
http://hdl.handle.net/20.500.12110/paper_0039128X_v74_n4-5_p435_Acebedo |
| work_keys_str_mv |
AT acebedosl synthesisandbiologicalactivityofbrassinosteroidsfluorinatedatc2 AT ramirezja synthesisandbiologicalactivityofbrassinosteroidsfluorinatedatc2 AT galagovskylr synthesisandbiologicalactivityofbrassinosteroidsfluorinatedatc2 |
| _version_ |
1807314949678039040 |