Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures

Aldosterone production from 11-deoxycorticosterone was stimulated by hemin in primary cultures and homogenates of calf adrenal zona glomerulosa, in a time- and dose-dependent fashion. The ferrochelatase inhibitor 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) blocked the stimulation...

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Detalles Bibliográficos
Autores principales: Cozza, E.N., Vila, M.d.C., Gomez-Sanchez, C.E.
Formato: JOUR
Materias:
aldosterone stimulation, hemin
hemin, aldosterone stimulation
1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester
aldosterone
corticotropin
cytochrome p450
hemin
adrenal cell
aldosterone release
animal cell
cattle
cell culture
conference paper
controlled study
dose time effect relation
enzyme activity
incubation time
liver metabolism
metabolic regulation
nonhuman
steroidogenesis
zona glomerulosa
Aldosterone
Animal
Cattle
Cells, Cultured
Corticotropin
Dicarbethoxydihydrocollidine
Female
Ferrochelatase
Hemin
Kinetics
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
Zona Glomerulosa
Animalia
Bos taurus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0039128X_v58_n8_p384_Cozza
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Aldosterone production from 11-deoxycorticosterone was stimulated by hemin in primary cultures and homogenates of calf adrenal zona glomerulosa, in a time- and dose-dependent fashion. The ferrochelatase inhibitor 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) blocked the stimulation of aldosterone mediated by adrenocorticotropin (ACTH). Addition of hemin after treatment with DDC partially restored ACTH action. These results suggest that hemin may play a role in regulation of aldosterone production. © 1993.

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