Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures

Aldosterone production from 11-deoxycorticosterone was stimulated by hemin in primary cultures and homogenates of calf adrenal zona glomerulosa, in a time- and dose-dependent fashion. The ferrochelatase inhibitor 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) blocked the stimulation...

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Autores principales: Cozza, E.N., Vila, M.d.C., Gomez-Sanchez, C.E.
Formato: JOUR
Materias:
aldosterone stimulation, hemin
hemin, aldosterone stimulation
1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester
aldosterone
corticotropin
cytochrome p450
hemin
adrenal cell
aldosterone release
animal cell
cattle
cell culture
conference paper
controlled study
dose time effect relation
enzyme activity
incubation time
liver metabolism
metabolic regulation
nonhuman
steroidogenesis
zona glomerulosa
Aldosterone
Animal
Cattle
Cells, Cultured
Corticotropin
Dicarbethoxydihydrocollidine
Female
Ferrochelatase
Hemin
Kinetics
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
Zona Glomerulosa
Animalia
Bos taurus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0039128X_v58_n8_p384_Cozza
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0039128X_v58_n8_p384_Cozza
record_format dspace
spelling todo:paper_0039128X_v58_n8_p384_Cozza2023-10-03T14:49:22Z Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures Cozza, E.N. Vila, M.d.C. Gomez-Sanchez, C.E. aldosterone stimulation, hemin hemin, aldosterone stimulation 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester aldosterone corticotropin cytochrome p450 hemin adrenal cell aldosterone release animal cell cattle cell culture conference paper controlled study dose time effect relation enzyme activity incubation time liver metabolism metabolic regulation nonhuman steroidogenesis zona glomerulosa Aldosterone Animal Cattle Cells, Cultured Corticotropin Dicarbethoxydihydrocollidine Female Ferrochelatase Hemin Kinetics Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Bos taurus Aldosterone production from 11-deoxycorticosterone was stimulated by hemin in primary cultures and homogenates of calf adrenal zona glomerulosa, in a time- and dose-dependent fashion. The ferrochelatase inhibitor 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) blocked the stimulation of aldosterone mediated by adrenocorticotropin (ACTH). Addition of hemin after treatment with DDC partially restored ACTH action. These results suggest that hemin may play a role in regulation of aldosterone production. © 1993. Fil:Cozza, E.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vila, M.d.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0039128X_v58_n8_p384_Cozza
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic aldosterone stimulation, hemin
hemin, aldosterone stimulation
1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester
aldosterone
corticotropin
cytochrome p450
hemin
adrenal cell
aldosterone release
animal cell
cattle
cell culture
conference paper
controlled study
dose time effect relation
enzyme activity
incubation time
liver metabolism
metabolic regulation
nonhuman
steroidogenesis
zona glomerulosa
Aldosterone
Animal
Cattle
Cells, Cultured
Corticotropin
Dicarbethoxydihydrocollidine
Female
Ferrochelatase
Hemin
Kinetics
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
Zona Glomerulosa
Animalia
Bos taurus
spellingShingle aldosterone stimulation, hemin
hemin, aldosterone stimulation
1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester
aldosterone
corticotropin
cytochrome p450
hemin
adrenal cell
aldosterone release
animal cell
cattle
cell culture
conference paper
controlled study
dose time effect relation
enzyme activity
incubation time
liver metabolism
metabolic regulation
nonhuman
steroidogenesis
zona glomerulosa
Aldosterone
Animal
Cattle
Cells, Cultured
Corticotropin
Dicarbethoxydihydrocollidine
Female
Ferrochelatase
Hemin
Kinetics
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
Zona Glomerulosa
Animalia
Bos taurus
Cozza, E.N.
Vila, M.d.C.
Gomez-Sanchez, C.E.
Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
topic_facet aldosterone stimulation, hemin
hemin, aldosterone stimulation
1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester
aldosterone
corticotropin
cytochrome p450
hemin
adrenal cell
aldosterone release
animal cell
cattle
cell culture
conference paper
controlled study
dose time effect relation
enzyme activity
incubation time
liver metabolism
metabolic regulation
nonhuman
steroidogenesis
zona glomerulosa
Aldosterone
Animal
Cattle
Cells, Cultured
Corticotropin
Dicarbethoxydihydrocollidine
Female
Ferrochelatase
Hemin
Kinetics
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
Zona Glomerulosa
Animalia
Bos taurus
description Aldosterone production from 11-deoxycorticosterone was stimulated by hemin in primary cultures and homogenates of calf adrenal zona glomerulosa, in a time- and dose-dependent fashion. The ferrochelatase inhibitor 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) blocked the stimulation of aldosterone mediated by adrenocorticotropin (ACTH). Addition of hemin after treatment with DDC partially restored ACTH action. These results suggest that hemin may play a role in regulation of aldosterone production. © 1993.
format JOUR
author Cozza, E.N.
Vila, M.d.C.
Gomez-Sanchez, C.E.
author_facet Cozza, E.N.
Vila, M.d.C.
Gomez-Sanchez, C.E.
author_sort Cozza, E.N.
title Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
title_short Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
title_full Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
title_fullStr Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
title_full_unstemmed Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
title_sort stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
url http://hdl.handle.net/20.500.12110/paper_0039128X_v58_n8_p384_Cozza
work_keys_str_mv AT cozzaen stimulationofaldosteroneproductionbyheminincalfadrenalglomerulosacellcultures
AT vilamdc stimulationofaldosteroneproductionbyheminincalfadrenalglomerulosacellcultures
AT gomezsanchezce stimulationofaldosteroneproductionbyheminincalfadrenalglomerulosacellcultures
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