Enhanced Glomerulopressin Production and Glomerular Filtration Rate by Amino Acid Infusion in Normal Humans
Amino acid infusion induces a rise in glomerular filtration rate (GFR) in normal subjects, but the mechanism is as yet unknown. Glomerulopressin infused into the renal arteries of rats and dogs increases GFR. The aim of this study was to ascertain whether amino acid infusion raised glomerulopressin...
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todo:paper_00379727_v196_n2_p170_Maggiora2023-10-03T14:48:13Z Enhanced Glomerulopressin Production and Glomerular Filtration Rate by Amino Acid Infusion in Normal Humans Maggiora, E. Silberstein, C. Arany, E. Salvidea, J.C. Castillo, E.D. Uranga, J. amino acid glomerulopressin unclassified drug article female glomerulus filtration rate human human experiment human tissue kidney donor male normal human priority journal Adult Amino Acids Analysis of Variance Female Glomerular Filtration Rate Glucuronates Glucuronidase Human Infusions, Intravenous Kidney Glomerulus Male Regional Blood Flow Support, Non-U.S. Gov't Anura Canis familiaris Glomerulus Amino acid infusion induces a rise in glomerular filtration rate (GFR) in normal subjects, but the mechanism is as yet unknown. Glomerulopressin infused into the renal arteries of rats and dogs increases GFR. The aim of this study was to ascertain whether amino acid infusion raised glomerulopressin production and GFR. Accordingly, before renal arteriovenography, in 11 potential kidney donors, the caval catheter was introduced into the right hepatic vein and 60-ml blood samples were collected at the beginning and end of each experiment; six patients received amino acid infusion and five a saline infusion. Glomerulopressin in ultrafiltrates from hepatic vein plasma was measured by toad bioassay and GFR determined with diethylenetriamine pentaacetic acid-Tc99. The amino acid-infused group showed significant glomerulopressin activity in ultrafiltrates, as well as a significant GFR increase, whereas in the control group no glomerulopressin activity was observed, and there was no change in GFR. These findings suggest that intravenous amino acid infusion stimulates glomerulopressin production, which may in turn induce an increase in GFR. © 1991, SAGE Publications. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00379727_v196_n2_p170_Maggiora |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
amino acid glomerulopressin unclassified drug article female glomerulus filtration rate human human experiment human tissue kidney donor male normal human priority journal Adult Amino Acids Analysis of Variance Female Glomerular Filtration Rate Glucuronates Glucuronidase Human Infusions, Intravenous Kidney Glomerulus Male Regional Blood Flow Support, Non-U.S. Gov't Anura Canis familiaris Glomerulus |
| spellingShingle |
amino acid glomerulopressin unclassified drug article female glomerulus filtration rate human human experiment human tissue kidney donor male normal human priority journal Adult Amino Acids Analysis of Variance Female Glomerular Filtration Rate Glucuronates Glucuronidase Human Infusions, Intravenous Kidney Glomerulus Male Regional Blood Flow Support, Non-U.S. Gov't Anura Canis familiaris Glomerulus Maggiora, E. Silberstein, C. Arany, E. Salvidea, J.C. Castillo, E.D. Uranga, J. Enhanced Glomerulopressin Production and Glomerular Filtration Rate by Amino Acid Infusion in Normal Humans |
| topic_facet |
amino acid glomerulopressin unclassified drug article female glomerulus filtration rate human human experiment human tissue kidney donor male normal human priority journal Adult Amino Acids Analysis of Variance Female Glomerular Filtration Rate Glucuronates Glucuronidase Human Infusions, Intravenous Kidney Glomerulus Male Regional Blood Flow Support, Non-U.S. Gov't Anura Canis familiaris Glomerulus |
| description |
Amino acid infusion induces a rise in glomerular filtration rate (GFR) in normal subjects, but the mechanism is as yet unknown. Glomerulopressin infused into the renal arteries of rats and dogs increases GFR. The aim of this study was to ascertain whether amino acid infusion raised glomerulopressin production and GFR. Accordingly, before renal arteriovenography, in 11 potential kidney donors, the caval catheter was introduced into the right hepatic vein and 60-ml blood samples were collected at the beginning and end of each experiment; six patients received amino acid infusion and five a saline infusion. Glomerulopressin in ultrafiltrates from hepatic vein plasma was measured by toad bioassay and GFR determined with diethylenetriamine pentaacetic acid-Tc99. The amino acid-infused group showed significant glomerulopressin activity in ultrafiltrates, as well as a significant GFR increase, whereas in the control group no glomerulopressin activity was observed, and there was no change in GFR. These findings suggest that intravenous amino acid infusion stimulates glomerulopressin production, which may in turn induce an increase in GFR. © 1991, SAGE Publications. All rights reserved. |
| format |
JOUR |
| author |
Maggiora, E. Silberstein, C. Arany, E. Salvidea, J.C. Castillo, E.D. Uranga, J. |
| author_facet |
Maggiora, E. Silberstein, C. Arany, E. Salvidea, J.C. Castillo, E.D. Uranga, J. |
| author_sort |
Maggiora, E. |
| title |
Enhanced Glomerulopressin Production and Glomerular Filtration Rate by Amino Acid Infusion in Normal Humans |
| title_short |
Enhanced Glomerulopressin Production and Glomerular Filtration Rate by Amino Acid Infusion in Normal Humans |
| title_full |
Enhanced Glomerulopressin Production and Glomerular Filtration Rate by Amino Acid Infusion in Normal Humans |
| title_fullStr |
Enhanced Glomerulopressin Production and Glomerular Filtration Rate by Amino Acid Infusion in Normal Humans |
| title_full_unstemmed |
Enhanced Glomerulopressin Production and Glomerular Filtration Rate by Amino Acid Infusion in Normal Humans |
| title_sort |
enhanced glomerulopressin production and glomerular filtration rate by amino acid infusion in normal humans |
| url |
http://hdl.handle.net/20.500.12110/paper_00379727_v196_n2_p170_Maggiora |
| work_keys_str_mv |
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