ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain

Baclofen, a GABA B agonist, inhibits prolactin release due to different kinds of stress. In the present study its effect was evaluated in several endocrine experimental situations to explore the specificity of this effect, as well as the site of action of the drug. Baclofen significantly inhibited p...

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Autores principales:	Lux, V.A.R., Somoza, G.M., Libertun, C.
Formato:	JOUR
Materias:	4 aminobutyric acid b receptor 4 aminobutyric acid receptor baclofen dopamine prolactin thyrotropin animal experiment brain central nervous system drug mechanism drug monitoring drug receptor binding endocrine system hormone release hypophysis intraperitoneal drug administration median eminence nonhuman preliminary communication priority journal rat Animal Animals, Suckling Baclofen Brain Female Luteinizing Hormone Male Median Eminence Physical Stimulation Pituitary Gland Prolactin Rats Rats, Inbred Strains Thyrotropin
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00379727_v183_n3_p358_Lux
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00379727_v183_n3_p358_Lux2023-10-03T14:48:12Z ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain Lux, V.A.R. Somoza, G.M. Libertun, C. 4 aminobutyric acid b receptor 4 aminobutyric acid receptor baclofen dopamine prolactin thyrotropin animal experiment brain central nervous system drug mechanism drug monitoring drug receptor binding endocrine system hormone release hypophysis intraperitoneal drug administration median eminence nonhuman preliminary communication priority journal rat Animal Animals, Suckling Baclofen Brain Female Luteinizing Hormone Male Median Eminence Physical Stimulation Pituitary Gland Prolactin Rats Rats, Inbred Strains Thyrotropin Baclofen, a GABA B agonist, inhibits prolactin release due to different kinds of stress. In the present study its effect was evaluated in several endocrine experimental situations to explore the specificity of this effect, as well as the site of action of the drug. Baclofen significantly inhibited prolactin and thyrotropin outputs induced by 25 min of suckling, without altering milk ejection or LH secretion. The effect was also tested in median eminence-lesioned rats and in in vitro incubations. Baclofen did not modify prolactin levels in rats in which brain control of the pituitary secretion was eliminated by destruction of the median eminence, and it did not inhibit prolactin or thyrotropin secretion from incubated hemipituitaries. It is postulated that baclofen inhibits prolactin and thyrotropin secretion by acting on GABA B receptors related to the brain control of pituitary secretion. © 1986, SAGE Publications. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00379727_v183_n3_p358_Lux
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	4 aminobutyric acid b receptor 4 aminobutyric acid receptor baclofen dopamine prolactin thyrotropin animal experiment brain central nervous system drug mechanism drug monitoring drug receptor binding endocrine system hormone release hypophysis intraperitoneal drug administration median eminence nonhuman preliminary communication priority journal rat Animal Animals, Suckling Baclofen Brain Female Luteinizing Hormone Male Median Eminence Physical Stimulation Pituitary Gland Prolactin Rats Rats, Inbred Strains Thyrotropin
spellingShingle	4 aminobutyric acid b receptor 4 aminobutyric acid receptor baclofen dopamine prolactin thyrotropin animal experiment brain central nervous system drug mechanism drug monitoring drug receptor binding endocrine system hormone release hypophysis intraperitoneal drug administration median eminence nonhuman preliminary communication priority journal rat Animal Animals, Suckling Baclofen Brain Female Luteinizing Hormone Male Median Eminence Physical Stimulation Pituitary Gland Prolactin Rats Rats, Inbred Strains Thyrotropin Lux, V.A.R. Somoza, G.M. Libertun, C. ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain
topic_facet	4 aminobutyric acid b receptor 4 aminobutyric acid receptor baclofen dopamine prolactin thyrotropin animal experiment brain central nervous system drug mechanism drug monitoring drug receptor binding endocrine system hormone release hypophysis intraperitoneal drug administration median eminence nonhuman preliminary communication priority journal rat Animal Animals, Suckling Baclofen Brain Female Luteinizing Hormone Male Median Eminence Physical Stimulation Pituitary Gland Prolactin Rats Rats, Inbred Strains Thyrotropin
description	Baclofen, a GABA B agonist, inhibits prolactin release due to different kinds of stress. In the present study its effect was evaluated in several endocrine experimental situations to explore the specificity of this effect, as well as the site of action of the drug. Baclofen significantly inhibited prolactin and thyrotropin outputs induced by 25 min of suckling, without altering milk ejection or LH secretion. The effect was also tested in median eminence-lesioned rats and in in vitro incubations. Baclofen did not modify prolactin levels in rats in which brain control of the pituitary secretion was eliminated by destruction of the median eminence, and it did not inhibit prolactin or thyrotropin secretion from incubated hemipituitaries. It is postulated that baclofen inhibits prolactin and thyrotropin secretion by acting on GABA B receptors related to the brain control of pituitary secretion. © 1986, SAGE Publications. All rights reserved.
format	JOUR
author	Lux, V.A.R. Somoza, G.M. Libertun, C.
author_facet	Lux, V.A.R. Somoza, G.M. Libertun, C.
author_sort	Lux, V.A.R.
title	ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain
title_short	ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain
title_full	ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain
title_fullStr	ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain
title_full_unstemmed	ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain
title_sort	ᵦ-(-4 chlorophenyl) gaba (baclofen) inhibits prolactin and thyrotropin release by acting on the rat brain
url	http://hdl.handle.net/20.500.12110/paper_00379727_v183_n3_p358_Lux
work_keys_str_mv	AT luxvar β4chlorophenylgababaclofeninhibitsprolactinandthyrotropinreleasebyactingontheratbrain AT somozagm β4chlorophenylgababaclofeninhibitsprolactinandthyrotropinreleasebyactingontheratbrain AT libertunc β4chlorophenylgababaclofeninhibitsprolactinandthyrotropinreleasebyactingontheratbrain
_version_	1807317191736950784

ᵦ-(-4 Chlorophenyl) GABA (Baclofen) Inhibits Prolactin and Thyrotropin Release by Acting on the Rat Brain

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