Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental
Chronic synovitis is an unsolved problem in hemophilic patients still today. Synoviorthesis proves effective among the possible treatments. The use of radioactive agents such as 198 Au-colloidal gold and 90 Y-colloidal Yttrium presents limitations due to age and joint size, Instead, Rifamicine my be...
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0032745X_v84_n7_p716_Maffei |
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todo:paper_0032745X_v84_n7_p716_Maffei2023-10-03T14:45:23Z Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental Maffei, M.E. Kujareuk, M. Barrionuevo, A. Galatro, G. Caviglia, H. gold 198 rifamycin yttrium article hemarthrosis hemophilia hyperplasia injection synovitis treatment outcome Chronic synovitis is an unsolved problem in hemophilic patients still today. Synoviorthesis proves effective among the possible treatments. The use of radioactive agents such as 198 Au-colloidal gold and 90 Y-colloidal Yttrium presents limitations due to age and joint size, Instead, Rifamicine my be used in children with open cartilages and in small joints. Its action mechanism has not been tried with hemophilic patients up to the present moment. The objective of the present paper is to demonstrate how Rifamicine works on rabbit knees with synovitis caused through intra-articular blood injection. We used 18 New Zeeland white rabbits (approximately 6 months old and 1.5 - 2.5 kg weight). An intra-articular injection of 1 ml homologous blood in the right knee was used twice a day for 8 weeks with the purpose of producing a synovitis. The left knees served as controls and received injections at the same time of normal saline solution. Two rabbits were killed to observe intraarticular alterations. The remaining rabbits received 1 ml (5 mg) intra-articular Rifamicine each 7 days for 2 weeks. Four were killed at 10 weeks; 4 at 11; 4 at 12 and 4 at 16 weeks. The joints were studied histologically and the reactional phenomenae that had been produced by Rifamicine on the vascular hyperplasia of the synovitis secondary to hemarthrosis were observed. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0032745X_v84_n7_p716_Maffei |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
gold 198 rifamycin yttrium article hemarthrosis hemophilia hyperplasia injection synovitis treatment outcome |
| spellingShingle |
gold 198 rifamycin yttrium article hemarthrosis hemophilia hyperplasia injection synovitis treatment outcome Maffei, M.E. Kujareuk, M. Barrionuevo, A. Galatro, G. Caviglia, H. Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental |
| topic_facet |
gold 198 rifamycin yttrium article hemarthrosis hemophilia hyperplasia injection synovitis treatment outcome |
| description |
Chronic synovitis is an unsolved problem in hemophilic patients still today. Synoviorthesis proves effective among the possible treatments. The use of radioactive agents such as 198 Au-colloidal gold and 90 Y-colloidal Yttrium presents limitations due to age and joint size, Instead, Rifamicine my be used in children with open cartilages and in small joints. Its action mechanism has not been tried with hemophilic patients up to the present moment. The objective of the present paper is to demonstrate how Rifamicine works on rabbit knees with synovitis caused through intra-articular blood injection. We used 18 New Zeeland white rabbits (approximately 6 months old and 1.5 - 2.5 kg weight). An intra-articular injection of 1 ml homologous blood in the right knee was used twice a day for 8 weeks with the purpose of producing a synovitis. The left knees served as controls and received injections at the same time of normal saline solution. Two rabbits were killed to observe intraarticular alterations. The remaining rabbits received 1 ml (5 mg) intra-articular Rifamicine each 7 days for 2 weeks. Four were killed at 10 weeks; 4 at 11; 4 at 12 and 4 at 16 weeks. The joints were studied histologically and the reactional phenomenae that had been produced by Rifamicine on the vascular hyperplasia of the synovitis secondary to hemarthrosis were observed. |
| format |
JOUR |
| author |
Maffei, M.E. Kujareuk, M. Barrionuevo, A. Galatro, G. Caviglia, H. |
| author_facet |
Maffei, M.E. Kujareuk, M. Barrionuevo, A. Galatro, G. Caviglia, H. |
| author_sort |
Maffei, M.E. |
| title |
Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental |
| title_short |
Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental |
| title_full |
Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental |
| title_fullStr |
Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental |
| title_full_unstemmed |
Tratamiento de la sinovitis hemofilica con rifocina: Estudio Experimental |
| title_sort |
tratamiento de la sinovitis hemofilica con rifocina: estudio experimental |
| url |
http://hdl.handle.net/20.500.12110/paper_0032745X_v84_n7_p716_Maffei |
| work_keys_str_mv |
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