Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture
A sulphated galactan (SG) with low molecular weight (app. 2800) was isolated from extracts of Cryptopleura ramoso, a red seaweed from the South American coasts. The compound was a selective inhibitor of HSV-1 and HSV-2 replication in Vero cells with 50% inhibitory concentrations (IC 50 ,) in the ran...
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todo:paper_00320943_v63_n5_p429_Carlucci2023-10-03T14:45:05Z Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture Carlucci, M.J. Scolaro, L.A. Errea, M.I. Matulewicz, M.C. Damonte, E.B. Cryptopleura ramosa Delesseriaceae Herpes simplex virus Natural antiviral Red seaweed Sulphated polisaccharide cryptopleura romosa extract galactan plant extract unclassified drug anticoagulation antiviral activity article cytotoxicity drug isolation herpes simplex virus nonhuman virus adsorption virus replication Algae, Red Animals Antiviral Agents Astrocytes Cell Survival Cells, Cultured Cercopithecus aethiops Galactans Herpesvirus 1, Human Herpesvirus 2, Human Humans Mice Plants, Medicinal Seawater Vero Cells Virus Replication algae Cryptopleura Cryptopleura ramosa Delesseriaceae Herpes Herpesviridae Human herpesvirus 1 Human herpesvirus 2 Murinae Simplexvirus A sulphated galactan (SG) with low molecular weight (app. 2800) was isolated from extracts of Cryptopleura ramoso, a red seaweed from the South American coasts. The compound was a selective inhibitor of HSV-1 and HSV-2 replication in Vero cells with 50% inhibitory concentrations (IC 50 ,) in the range 1.6 - 4.2μg/ml and a 50% cytotoxic concentration (CC 50 )) of 476 μg/ml. SG was also effective against HSV-1 in cells of neural origin such as murine astrocytes. The mode of action of SG could be ascribed to an inhibitory action on virus adsorption. Furthermore, SG did not inhibit the blood coagulation process at concentrations highly exceeding the IC 50 . Fil:Carlucci, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Scolaro, L.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Errea, M.I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Matulewicz, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00320943_v63_n5_p429_Carlucci |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cryptopleura ramosa Delesseriaceae Herpes simplex virus Natural antiviral Red seaweed Sulphated polisaccharide cryptopleura romosa extract galactan plant extract unclassified drug anticoagulation antiviral activity article cytotoxicity drug isolation herpes simplex virus nonhuman virus adsorption virus replication Algae, Red Animals Antiviral Agents Astrocytes Cell Survival Cells, Cultured Cercopithecus aethiops Galactans Herpesvirus 1, Human Herpesvirus 2, Human Humans Mice Plants, Medicinal Seawater Vero Cells Virus Replication algae Cryptopleura Cryptopleura ramosa Delesseriaceae Herpes Herpesviridae Human herpesvirus 1 Human herpesvirus 2 Murinae Simplexvirus |
| spellingShingle |
Cryptopleura ramosa Delesseriaceae Herpes simplex virus Natural antiviral Red seaweed Sulphated polisaccharide cryptopleura romosa extract galactan plant extract unclassified drug anticoagulation antiviral activity article cytotoxicity drug isolation herpes simplex virus nonhuman virus adsorption virus replication Algae, Red Animals Antiviral Agents Astrocytes Cell Survival Cells, Cultured Cercopithecus aethiops Galactans Herpesvirus 1, Human Herpesvirus 2, Human Humans Mice Plants, Medicinal Seawater Vero Cells Virus Replication algae Cryptopleura Cryptopleura ramosa Delesseriaceae Herpes Herpesviridae Human herpesvirus 1 Human herpesvirus 2 Murinae Simplexvirus Carlucci, M.J. Scolaro, L.A. Errea, M.I. Matulewicz, M.C. Damonte, E.B. Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture |
| topic_facet |
Cryptopleura ramosa Delesseriaceae Herpes simplex virus Natural antiviral Red seaweed Sulphated polisaccharide cryptopleura romosa extract galactan plant extract unclassified drug anticoagulation antiviral activity article cytotoxicity drug isolation herpes simplex virus nonhuman virus adsorption virus replication Algae, Red Animals Antiviral Agents Astrocytes Cell Survival Cells, Cultured Cercopithecus aethiops Galactans Herpesvirus 1, Human Herpesvirus 2, Human Humans Mice Plants, Medicinal Seawater Vero Cells Virus Replication algae Cryptopleura Cryptopleura ramosa Delesseriaceae Herpes Herpesviridae Human herpesvirus 1 Human herpesvirus 2 Murinae Simplexvirus |
| description |
A sulphated galactan (SG) with low molecular weight (app. 2800) was isolated from extracts of Cryptopleura ramoso, a red seaweed from the South American coasts. The compound was a selective inhibitor of HSV-1 and HSV-2 replication in Vero cells with 50% inhibitory concentrations (IC 50 ,) in the range 1.6 - 4.2μg/ml and a 50% cytotoxic concentration (CC 50 )) of 476 μg/ml. SG was also effective against HSV-1 in cells of neural origin such as murine astrocytes. The mode of action of SG could be ascribed to an inhibitory action on virus adsorption. Furthermore, SG did not inhibit the blood coagulation process at concentrations highly exceeding the IC 50 . |
| format |
JOUR |
| author |
Carlucci, M.J. Scolaro, L.A. Errea, M.I. Matulewicz, M.C. Damonte, E.B. |
| author_facet |
Carlucci, M.J. Scolaro, L.A. Errea, M.I. Matulewicz, M.C. Damonte, E.B. |
| author_sort |
Carlucci, M.J. |
| title |
Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture |
| title_short |
Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture |
| title_full |
Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture |
| title_fullStr |
Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture |
| title_full_unstemmed |
Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture |
| title_sort |
antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture |
| url |
http://hdl.handle.net/20.500.12110/paper_00320943_v63_n5_p429_Carlucci |
| work_keys_str_mv |
AT carluccimj antiviralactivityofnaturalsulphatedgalactansonherpesvirusmultiplicationincellculture AT scolarola antiviralactivityofnaturalsulphatedgalactansonherpesvirusmultiplicationincellculture AT erreami antiviralactivityofnaturalsulphatedgalactansonherpesvirusmultiplicationincellculture AT matulewiczmc antiviralactivityofnaturalsulphatedgalactansonherpesvirusmultiplicationincellculture AT damonteeb antiviralactivityofnaturalsulphatedgalactansonherpesvirusmultiplicationincellculture |
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1807323584167673856 |