Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety

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In this study we tested whether periodic maternal deprivation (MD) (4.5 h daily during the first 3 weeks of life) caused chronic changes in anxiety and medullo-adrenal responses to chronic stress in either male or female adult (2.5 months of age) rats, or both. Repeated maternal deprivation had a se...

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Autores principales: Renard, G.M., Suárez, M.M., Levin, G.M., Rivarola, M.A.
Formato: JOUR
Lenguaje:English
Materias:
Anxiety
Epinephrine
Functional sex differences
Maternal deprivation
Norepinephrine
Stress
adrenalin
noradrenalin
adrenergic system
animal behavior
animal experiment
animal model
anxiety
article
controlled study
female
male
maze test
medulla oblongata
nonhuman
prediction
priority journal
rat
separation anxiety
sex difference
stress
Analysis of Variance
Animals
Animals, Newborn
Behavior, Animal
Female
Male
Maternal Deprivation
Maze Learning
Rats
Rats, Wistar
Sex Characteristics
Sex Factors
Time Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00319384_v85_n3_p363_Renard
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_00319384_v85_n3_p363_Renard2023-10-03T14:43:47Z Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety Renard, G.M. Suárez, M.M. Levin, G.M. Rivarola, M.A. Anxiety Epinephrine Functional sex differences Maternal deprivation Norepinephrine Stress adrenalin noradrenalin adrenergic system animal behavior animal experiment animal model anxiety article controlled study female male maze test medulla oblongata nonhuman prediction priority journal rat separation anxiety sex difference stress Analysis of Variance Animals Animals, Newborn Anxiety Behavior, Animal Epinephrine Female Male Maternal Deprivation Maze Learning Norepinephrine Rats Rats, Wistar Sex Characteristics Sex Factors Stress Time Factors In this study we tested whether periodic maternal deprivation (MD) (4.5 h daily during the first 3 weeks of life) caused chronic changes in anxiety and medullo-adrenal responses to chronic stress in either male or female adult (2.5 months of age) rats, or both. Repeated maternal deprivation had a sex-specific effect on epinephrine (E) and norepinephrine (NE) levels: an increase in both measures was observed only in females. Unpredictable stress did not produce changes on plasma catecholamine levels either in males or females. However, when the females were maternally deprived as well as stressed they showed an increase in plasma NE p < 0.05. On the other hand, non-maternally deprived (NMD), maternally-deprived and stressed males showed high levels of catecholamines compared to females p < 0.001. In the elevated plus maze test, MD-treated males displayed a slight increase in anxiety-related behavior compared with NMD rats. This was indicated by a reduction in the time spent on the open arms, whereas females showed less anxiety, indicated by an increase in the number of entries, and in the time spent on the open arms. After exposure to chronic stress only the females displayed decreased anxiety-related behavior. These results suggest that there are sex-induced effects in emotional reactivity, perception of the stressor and in the evaluation of novel situations. Thus, maternal deprivation and chronic variable stress caused both long-term alterations in sympathetic response and gender-dependent changes in the anxiety index of adult rats. © 2005 Elsevier Inc. All rights reserved. JOUR English info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00319384_v85_n3_p363_Renard
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language English
orig_language_str_mv English
topic Anxiety
Epinephrine
Functional sex differences
Maternal deprivation
Norepinephrine
Stress
adrenalin
noradrenalin
adrenergic system
animal behavior
animal experiment
animal model
anxiety
article
controlled study
female
male
maze test
medulla oblongata
nonhuman
prediction
priority journal
rat
separation anxiety
sex difference
stress
Analysis of Variance
Animals
Animals, Newborn
Anxiety
Behavior, Animal
Epinephrine
Female
Male
Maternal Deprivation
Maze Learning
Norepinephrine
Rats
Rats, Wistar
Sex Characteristics
Sex Factors
Stress
Time Factors
spellingShingle Anxiety
Epinephrine
Functional sex differences
Maternal deprivation
Norepinephrine
Stress
adrenalin
noradrenalin
adrenergic system
animal behavior
animal experiment
animal model
anxiety
article
controlled study
female
male
maze test
medulla oblongata
nonhuman
prediction
priority journal
rat
separation anxiety
sex difference
stress
Analysis of Variance
Animals
Animals, Newborn
Anxiety
Behavior, Animal
Epinephrine
Female
Male
Maternal Deprivation
Maze Learning
Norepinephrine
Rats
Rats, Wistar
Sex Characteristics
Sex Factors
Stress
Time Factors
Renard, G.M.
Suárez, M.M.
Levin, G.M.
Rivarola, M.A.
Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety
topic_facet Anxiety
Epinephrine
Functional sex differences
Maternal deprivation
Norepinephrine
Stress
adrenalin
noradrenalin
adrenergic system
animal behavior
animal experiment
animal model
anxiety
article
controlled study
female
male
maze test
medulla oblongata
nonhuman
prediction
priority journal
rat
separation anxiety
sex difference
stress
Analysis of Variance
Animals
Animals, Newborn
Anxiety
Behavior, Animal
Epinephrine
Female
Male
Maternal Deprivation
Maze Learning
Norepinephrine
Rats
Rats, Wistar
Sex Characteristics
Sex Factors
Stress
Time Factors
description In this study we tested whether periodic maternal deprivation (MD) (4.5 h daily during the first 3 weeks of life) caused chronic changes in anxiety and medullo-adrenal responses to chronic stress in either male or female adult (2.5 months of age) rats, or both. Repeated maternal deprivation had a sex-specific effect on epinephrine (E) and norepinephrine (NE) levels: an increase in both measures was observed only in females. Unpredictable stress did not produce changes on plasma catecholamine levels either in males or females. However, when the females were maternally deprived as well as stressed they showed an increase in plasma NE p < 0.05. On the other hand, non-maternally deprived (NMD), maternally-deprived and stressed males showed high levels of catecholamines compared to females p < 0.001. In the elevated plus maze test, MD-treated males displayed a slight increase in anxiety-related behavior compared with NMD rats. This was indicated by a reduction in the time spent on the open arms, whereas females showed less anxiety, indicated by an increase in the number of entries, and in the time spent on the open arms. After exposure to chronic stress only the females displayed decreased anxiety-related behavior. These results suggest that there are sex-induced effects in emotional reactivity, perception of the stressor and in the evaluation of novel situations. Thus, maternal deprivation and chronic variable stress caused both long-term alterations in sympathetic response and gender-dependent changes in the anxiety index of adult rats. © 2005 Elsevier Inc. All rights reserved.
format JOUR
author Renard, G.M.
Suárez, M.M.
Levin, G.M.
Rivarola, M.A.
author_facet Renard, G.M.
Suárez, M.M.
Levin, G.M.
Rivarola, M.A.
author_sort Renard, G.M.
title Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety
title_short Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety
title_full Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety
title_fullStr Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety
title_full_unstemmed Sex differences in rats: Effects of chronic stress on sympathetic system and anxiety
title_sort sex differences in rats: effects of chronic stress on sympathetic system and anxiety
url http://hdl.handle.net/20.500.12110/paper_00319384_v85_n3_p363_Renard
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AT suarezmm sexdifferencesinratseffectsofchronicstressonsympatheticsystemandanxiety
AT levingm sexdifferencesinratseffectsofchronicstressonsympatheticsystemandanxiety
AT rivarolama sexdifferencesinratseffectsofchronicstressonsympatheticsystemandanxiety
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