Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin
The existence of angiotensin I converting enzyme (CE) activity in isolated sow Fallopian tubes and the "in vitro" influences of exogenous bradykinin (BK) on the spontaneous motility of sow oviducts, were explored, Independently of the stage of the sex cycle, the ampullary region of sow Fal...
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todo:paper_00316989_v18_n1_p49_FernandezPardal2023-10-03T14:41:29Z Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin Ferna ́ndez-Pardal, J. Chaud, M. Viggiano, M. Gimeno, M.F. Gimeno, A.L. acetylsalicylic acid bradykinin captopril dipeptidyl carboxypeptidase mefenamic acid prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha animal cell cattle drug efficacy drug interaction estrus female genital system in vitro study nonhuman priority journal swine uterine tube Animals Bradykinin Cyclooxygenase Inhibitors Estrus Fallopian Tubes Female Isometric Contraction Myocardial Contraction Peptidyl-Dipeptidase A Prostaglandin Antagonists Prostaglandins Swine The existence of angiotensin I converting enzyme (CE) activity in isolated sow Fallopian tubes and the "in vitro" influences of exogenous bradykinin (BK) on the spontaneous motility of sow oviducts, were explored, Independently of the stage of the sex cycle, the ampullary region of sow Fallopian tubes presented a higher basal CE activity than the isthmic one. On the other hand a greater CE activity was found in the isthmus at estrus and metestrus than at proestrus. Acetylsalicylic acid and mefenamic acid, two inhibitors of prostaglandin synthesis, reduced the CE activity only in ampullary segments obtained at metestrus. BK (0.06 μg.ml-1) stimulates the spontaneous contractions of isthmic and ampullary tubal segments, triggering tonic responses. The positive inotropism had a longer duration in the isthmus than in the ampulla; presented at estrus a higher magnitude than at proestrus and was enhanced by captopril (50 μg.ml-1). The data suggest that the low CE activity found in the isthmic tubal region could be subserving the positive inotropic action of BK in the isthmus, long lasting in comparison to that evoked in the ampulla. Moreover, at metestrus some tissue eicosanoid might be modulating the foregoing results could be explained assuming the presence of a car{ballot box}y-peptidase different than CE in one region of the oviducts and not in the other, i.e., either one with different sensitivity towards sex hormones and prostaglandin synthesis blockers. © 1986 The Italian Pharmacological Society. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00316989_v18_n1_p49_FernandezPardal |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
acetylsalicylic acid bradykinin captopril dipeptidyl carboxypeptidase mefenamic acid prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha animal cell cattle drug efficacy drug interaction estrus female genital system in vitro study nonhuman priority journal swine uterine tube Animals Bradykinin Cyclooxygenase Inhibitors Estrus Fallopian Tubes Female Isometric Contraction Myocardial Contraction Peptidyl-Dipeptidase A Prostaglandin Antagonists Prostaglandins Swine |
| spellingShingle |
acetylsalicylic acid bradykinin captopril dipeptidyl carboxypeptidase mefenamic acid prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha animal cell cattle drug efficacy drug interaction estrus female genital system in vitro study nonhuman priority journal swine uterine tube Animals Bradykinin Cyclooxygenase Inhibitors Estrus Fallopian Tubes Female Isometric Contraction Myocardial Contraction Peptidyl-Dipeptidase A Prostaglandin Antagonists Prostaglandins Swine Ferna ́ndez-Pardal, J. Chaud, M. Viggiano, M. Gimeno, M.F. Gimeno, A.L. Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin |
| topic_facet |
acetylsalicylic acid bradykinin captopril dipeptidyl carboxypeptidase mefenamic acid prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha animal cell cattle drug efficacy drug interaction estrus female genital system in vitro study nonhuman priority journal swine uterine tube Animals Bradykinin Cyclooxygenase Inhibitors Estrus Fallopian Tubes Female Isometric Contraction Myocardial Contraction Peptidyl-Dipeptidase A Prostaglandin Antagonists Prostaglandins Swine |
| description |
The existence of angiotensin I converting enzyme (CE) activity in isolated sow Fallopian tubes and the "in vitro" influences of exogenous bradykinin (BK) on the spontaneous motility of sow oviducts, were explored, Independently of the stage of the sex cycle, the ampullary region of sow Fallopian tubes presented a higher basal CE activity than the isthmic one. On the other hand a greater CE activity was found in the isthmus at estrus and metestrus than at proestrus. Acetylsalicylic acid and mefenamic acid, two inhibitors of prostaglandin synthesis, reduced the CE activity only in ampullary segments obtained at metestrus. BK (0.06 μg.ml-1) stimulates the spontaneous contractions of isthmic and ampullary tubal segments, triggering tonic responses. The positive inotropism had a longer duration in the isthmus than in the ampulla; presented at estrus a higher magnitude than at proestrus and was enhanced by captopril (50 μg.ml-1). The data suggest that the low CE activity found in the isthmic tubal region could be subserving the positive inotropic action of BK in the isthmus, long lasting in comparison to that evoked in the ampulla. Moreover, at metestrus some tissue eicosanoid might be modulating the foregoing results could be explained assuming the presence of a car{ballot box}y-peptidase different than CE in one region of the oviducts and not in the other, i.e., either one with different sensitivity towards sex hormones and prostaglandin synthesis blockers. © 1986 The Italian Pharmacological Society. |
| format |
JOUR |
| author |
Ferna ́ndez-Pardal, J. Chaud, M. Viggiano, M. Gimeno, M.F. Gimeno, A.L. |
| author_facet |
Ferna ́ndez-Pardal, J. Chaud, M. Viggiano, M. Gimeno, M.F. Gimeno, A.L. |
| author_sort |
Ferna ́ndez-Pardal, J. |
| title |
Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin |
| title_short |
Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin |
| title_full |
Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin |
| title_fullStr |
Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin |
| title_full_unstemmed |
Converting enzyme activity in sow oviducts at different stages of the sex cycle. Influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin |
| title_sort |
converting enzyme activity in sow oviducts at different stages of the sex cycle. influence of inhibitors of prostaglandin synthesis and its possible role in the inotropic effects of bradykinin |
| url |
http://hdl.handle.net/20.500.12110/paper_00316989_v18_n1_p49_FernandezPardal |
| work_keys_str_mv |
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1807314948557111296 |