Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms

Dose-response curves of the positive inotropic effect of PGF2α on isolated rat atria, were examined. It was found a distinct efficacy stimulating the contractile tension of isolated rat atria. The compound elicited a positive inotropism which was augmented in the presence of (-)-propranolol, subthre...

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Detalles Bibliográficos
Autores principales: Canga, L., Sterin-Borda, L., Pissani, A., Gimeno, A.L.
Formato: JOUR
Materias:
methoxamine
noradrenalin
phentolamine
propranolol
prostaglandin F
prostaglandin F2 alpha
adrenergic receptor
oxidopamine
prostaglandin f2 alpha
tyramine
adrenergic system
animal
article
chemical sympathectomy
drug effect
heart atrium
heart contraction
in vitro study
innervation
male
rat
rat strain
stimulation
animal experiment
autonomic nervous system
drug response
heart
heart muscle contractility
inotropism
Animal
Dinoprost
Heart Atrium
In Vitro
Male
Methoxamine
Myocardial Contraction
Norepinephrine
Phentolamine
Propranolol
Prostaglandins F
Rats
Rats, Inbred Strains
Stimulation, Chemical
Support, Non-U.S. Gov't
Sympathectomy, Chemical
Sympathetic Nervous System
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00316989_v13_n6_p559_Canga
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_00316989_v13_n6_p559_Canga2023-10-03T14:41:24Z Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms Canga, L. Sterin-Borda, L. Pissani, A. Gimeno, A.L. methoxamine noradrenalin phentolamine propranolol prostaglandin F prostaglandin F2 alpha adrenergic receptor methoxamine noradrenalin oxidopamine phentolamine propranolol prostaglandin f2 alpha tyramine adrenergic system animal article chemical sympathectomy drug effect heart atrium heart contraction in vitro study innervation male rat rat strain stimulation adrenergic system animal experiment autonomic nervous system drug response heart heart atrium heart muscle contractility inotropism Animal Dinoprost Heart Atrium In Vitro Male Methoxamine Myocardial Contraction Norepinephrine Phentolamine Propranolol Prostaglandins F Rats Rats, Inbred Strains Stimulation, Chemical Support, Non-U.S. Gov't Sympathectomy, Chemical Sympathetic Nervous System Dose-response curves of the positive inotropic effect of PGF2α on isolated rat atria, were examined. It was found a distinct efficacy stimulating the contractile tension of isolated rat atria. The compound elicited a positive inotropism which was augmented in the presence of (-)-propranolol, subthreshold doses of methoxamine, as well as after a treatment with 6-OHDA. On the contrary subthreshold concentrations of norepinephrine or the presence of phentolamine decreased the augmenting inotropic effect of PGF2α. The results suggest that the action of PGF2α is apparently direct and not mediated by the release of the tissue catecholamines. However, adrenergic mechanism appear to be somehow involved in the inotropic influence of PGF2α on the rat atria. © 1981 The Italian Pharmacological Society. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00316989_v13_n6_p559_Canga
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic methoxamine
noradrenalin
phentolamine
propranolol
prostaglandin F
prostaglandin F2 alpha
adrenergic receptor
methoxamine
noradrenalin
oxidopamine
phentolamine
propranolol
prostaglandin f2 alpha
tyramine
adrenergic system
animal
article
chemical sympathectomy
drug effect
heart atrium
heart contraction
in vitro study
innervation
male
rat
rat strain
stimulation
adrenergic system
animal experiment
autonomic nervous system
drug response
heart
heart atrium
heart muscle contractility
inotropism
Animal
Dinoprost
Heart Atrium
In Vitro
Male
Methoxamine
Myocardial Contraction
Norepinephrine
Phentolamine
Propranolol
Prostaglandins F
Rats
Rats, Inbred Strains
Stimulation, Chemical
Support, Non-U.S. Gov't
Sympathectomy, Chemical
Sympathetic Nervous System
spellingShingle methoxamine
noradrenalin
phentolamine
propranolol
prostaglandin F
prostaglandin F2 alpha
adrenergic receptor
methoxamine
noradrenalin
oxidopamine
phentolamine
propranolol
prostaglandin f2 alpha
tyramine
adrenergic system
animal
article
chemical sympathectomy
drug effect
heart atrium
heart contraction
in vitro study
innervation
male
rat
rat strain
stimulation
adrenergic system
animal experiment
autonomic nervous system
drug response
heart
heart atrium
heart muscle contractility
inotropism
Animal
Dinoprost
Heart Atrium
In Vitro
Male
Methoxamine
Myocardial Contraction
Norepinephrine
Phentolamine
Propranolol
Prostaglandins F
Rats
Rats, Inbred Strains
Stimulation, Chemical
Support, Non-U.S. Gov't
Sympathectomy, Chemical
Sympathetic Nervous System
Canga, L.
Sterin-Borda, L.
Pissani, A.
Gimeno, A.L.
Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms
topic_facet methoxamine
noradrenalin
phentolamine
propranolol
prostaglandin F
prostaglandin F2 alpha
adrenergic receptor
methoxamine
noradrenalin
oxidopamine
phentolamine
propranolol
prostaglandin f2 alpha
tyramine
adrenergic system
animal
article
chemical sympathectomy
drug effect
heart atrium
heart contraction
in vitro study
innervation
male
rat
rat strain
stimulation
adrenergic system
animal experiment
autonomic nervous system
drug response
heart
heart atrium
heart muscle contractility
inotropism
Animal
Dinoprost
Heart Atrium
In Vitro
Male
Methoxamine
Myocardial Contraction
Norepinephrine
Phentolamine
Propranolol
Prostaglandins F
Rats
Rats, Inbred Strains
Stimulation, Chemical
Support, Non-U.S. Gov't
Sympathectomy, Chemical
Sympathetic Nervous System
description Dose-response curves of the positive inotropic effect of PGF2α on isolated rat atria, were examined. It was found a distinct efficacy stimulating the contractile tension of isolated rat atria. The compound elicited a positive inotropism which was augmented in the presence of (-)-propranolol, subthreshold doses of methoxamine, as well as after a treatment with 6-OHDA. On the contrary subthreshold concentrations of norepinephrine or the presence of phentolamine decreased the augmenting inotropic effect of PGF2α. The results suggest that the action of PGF2α is apparently direct and not mediated by the release of the tissue catecholamines. However, adrenergic mechanism appear to be somehow involved in the inotropic influence of PGF2α on the rat atria. © 1981 The Italian Pharmacological Society.
format JOUR
author Canga, L.
Sterin-Borda, L.
Pissani, A.
Gimeno, A.L.
author_facet Canga, L.
Sterin-Borda, L.
Pissani, A.
Gimeno, A.L.
author_sort Canga, L.
title Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms
title_short Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms
title_full Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms
title_fullStr Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms
title_full_unstemmed Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms
title_sort inotropic effect of pgf2α on isolated rat atria. influence of adrenergic mechanisms
url http://hdl.handle.net/20.500.12110/paper_00316989_v13_n6_p559_Canga
work_keys_str_mv AT cangal inotropiceffectofpgf2aonisolatedratatriainfluenceofadrenergicmechanisms
AT sterinbordal inotropiceffectofpgf2aonisolatedratatriainfluenceofadrenergicmechanisms
AT pissania inotropiceffectofpgf2aonisolatedratatriainfluenceofadrenergicmechanisms
AT gimenoal inotropiceffectofpgf2aonisolatedratatriainfluenceofadrenergicmechanisms
_version_ 1807323582726930432

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