Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens
Responses to adrenoceptor agonistic drugs were examined in two regions of vasa deferentia (epididymal and prostetic) from adult intact and castrated rats. In the prostatic portion the stimulating alpha adrenergic responses following castration were greater than in the intact rats. On the other hand...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00316989_v13_n10_p981_Borda |
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todo:paper_00316989_v13_n10_p981_Borda2023-10-03T14:41:23Z Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens Borda, E. Agostini, M.d.C. Gimeno, M.F. Gimeno, A.L. acetylsalicylic acid alpha adrenergic receptor atropine beta adrenergic receptor butoxamine clonidine noradrenalin oxidopamine phentolamine phenylephrine soterenol testosterone testosterone propionate yohimbine animal experiment castration endocrine system male genital system rat smooth muscle contractility vas deferens Animal Castration Clonidine Ethanolamines In Vitro Male Muscle Contraction Norepinephrine Phenylephrine Rats Rats, Inbred Strains Sympathomimetics Testosterone Vas Deferens Responses to adrenoceptor agonistic drugs were examined in two regions of vasa deferentia (epididymal and prostetic) from adult intact and castrated rats. In the prostatic portion the stimulating alpha adrenergic responses following castration were greater than in the intact rats. On the other hand in the epididymal region the reactivity was smaller in preparations from castrated animals. A beta-adrenoceptor-inhibitory-mediated mechanism was only present in the epididymal segment of the castrated group; in which a clear spontaneous activity was observed. Testosterone treatment reversed the alpha and beta adrenergic effects detected after castration. Results show a relationship between testosterone and the spontaneous motility as well as an influence in the action of alpha and beta adrenergic agonists on their receptors. © 1981 The Italian Pharmacological Society. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00316989_v13_n10_p981_Borda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
acetylsalicylic acid alpha adrenergic receptor atropine beta adrenergic receptor butoxamine clonidine noradrenalin oxidopamine phentolamine phenylephrine soterenol testosterone testosterone propionate yohimbine animal experiment castration endocrine system male genital system rat smooth muscle contractility vas deferens Animal Castration Clonidine Ethanolamines In Vitro Male Muscle Contraction Norepinephrine Phenylephrine Rats Rats, Inbred Strains Sympathomimetics Testosterone Vas Deferens |
| spellingShingle |
acetylsalicylic acid alpha adrenergic receptor atropine beta adrenergic receptor butoxamine clonidine noradrenalin oxidopamine phentolamine phenylephrine soterenol testosterone testosterone propionate yohimbine animal experiment castration endocrine system male genital system rat smooth muscle contractility vas deferens Animal Castration Clonidine Ethanolamines In Vitro Male Muscle Contraction Norepinephrine Phenylephrine Rats Rats, Inbred Strains Sympathomimetics Testosterone Vas Deferens Borda, E. Agostini, M.d.C. Gimeno, M.F. Gimeno, A.L. Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens |
| topic_facet |
acetylsalicylic acid alpha adrenergic receptor atropine beta adrenergic receptor butoxamine clonidine noradrenalin oxidopamine phentolamine phenylephrine soterenol testosterone testosterone propionate yohimbine animal experiment castration endocrine system male genital system rat smooth muscle contractility vas deferens Animal Castration Clonidine Ethanolamines In Vitro Male Muscle Contraction Norepinephrine Phenylephrine Rats Rats, Inbred Strains Sympathomimetics Testosterone Vas Deferens |
| description |
Responses to adrenoceptor agonistic drugs were examined in two regions of vasa deferentia (epididymal and prostetic) from adult intact and castrated rats. In the prostatic portion the stimulating alpha adrenergic responses following castration were greater than in the intact rats. On the other hand in the epididymal region the reactivity was smaller in preparations from castrated animals. A beta-adrenoceptor-inhibitory-mediated mechanism was only present in the epididymal segment of the castrated group; in which a clear spontaneous activity was observed. Testosterone treatment reversed the alpha and beta adrenergic effects detected after castration. Results show a relationship between testosterone and the spontaneous motility as well as an influence in the action of alpha and beta adrenergic agonists on their receptors. © 1981 The Italian Pharmacological Society. |
| format |
JOUR |
| author |
Borda, E. Agostini, M.d.C. Gimeno, M.F. Gimeno, A.L. |
| author_facet |
Borda, E. Agostini, M.d.C. Gimeno, M.F. Gimeno, A.L. |
| author_sort |
Borda, E. |
| title |
Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens |
| title_short |
Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens |
| title_full |
Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens |
| title_fullStr |
Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens |
| title_full_unstemmed |
Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens |
| title_sort |
castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens |
| url |
http://hdl.handle.net/20.500.12110/paper_00316989_v13_n10_p981_Borda |
| work_keys_str_mv |
AT bordae castrationaltersthestimulatoryandinhibitoryadrenergicinfluencesonisolatedratvasdeferens AT agostinimdc castrationaltersthestimulatoryandinhibitoryadrenergicinfluencesonisolatedratvasdeferens AT gimenomf castrationaltersthestimulatoryandinhibitoryadrenergicinfluencesonisolatedratvasdeferens AT gimenoal castrationaltersthestimulatoryandinhibitoryadrenergicinfluencesonisolatedratvasdeferens |
| _version_ |
1807319572412366848 |