A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections
Over the last years, increasing evidence has fuelled the hypothesis that Autism Spectrum Disorder (ASD) is a condition of altered brain functional connectivity. The great majority of these empirical studies relies on functional magnetic resonance imaging (fMRI) which has a relatively poor temporal r...
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todo:paper_00283932_v49_n2_p254_Barttfeld2023-10-03T14:39:05Z A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections Barttfeld, P. Wicker, B. Cukier, S. Navarta, S. Lew, S. Sigman, M. Autism Spectrum Disorder Delta band EEG Functional connectivity Resting state Small world metrics adolescent adult article autism brain function calculation clinical article controlled study disease severity electroencephalography female frontal lobe functional assessment functional magnetic resonance imaging human male occipital cortex Adolescent Adult Asperger Syndrome Autistic Disorder Brain Mapping Cerebral Cortex Delta Rhythm Electroencephalography Female Humans Male Nerve Net Neural Pathways Young Adult Over the last years, increasing evidence has fuelled the hypothesis that Autism Spectrum Disorder (ASD) is a condition of altered brain functional connectivity. The great majority of these empirical studies relies on functional magnetic resonance imaging (fMRI) which has a relatively poor temporal resolution. Only a handful of studies has examined networks emerging from dynamic coherence at the millisecond resolution and there are no investigations of coherence at the lowest frequencies in the power spectrum-which has recently been shown to reflect long-range cortico-cortical connections. Here we used electroencephalography (EEG) to assess dynamic brain connectivity in ASD focusing in the low-frequency (delta) range. We found that connectivity patterns were distinct in ASD and control populations and reflected a double dissociation: ASD subjects lacked long-range connections, with a most prominent deficit in fronto-occipital connections. Conversely, individuals with ASD showed increased short-range connections in lateral-frontal electrodes. This effect between categories showed a consistent parametric dependency: as ASD severity increased, short-range coherence was more pronounced and long-range coherence decreased. Theoretical arguments have been proposed arguing that distinct patterns of connectivity may result in networks with different efficiency in transmission of information. We show that the networks in ASD subjects have less Clustering coefficient, greater Characteristic Path Length than controls - indicating that the topology of the network departs from small-world behaviour - and greater modularity. Together these results show that delta-band coherence reveal qualitative and quantitative aspects associated with ASD pathology. © 2010 Elsevier Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00283932_v49_n2_p254_Barttfeld |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Autism Spectrum Disorder Delta band EEG Functional connectivity Resting state Small world metrics adolescent adult article autism brain function calculation clinical article controlled study disease severity electroencephalography female frontal lobe functional assessment functional magnetic resonance imaging human male occipital cortex Adolescent Adult Asperger Syndrome Autistic Disorder Brain Mapping Cerebral Cortex Delta Rhythm Electroencephalography Female Humans Male Nerve Net Neural Pathways Young Adult |
| spellingShingle |
Autism Spectrum Disorder Delta band EEG Functional connectivity Resting state Small world metrics adolescent adult article autism brain function calculation clinical article controlled study disease severity electroencephalography female frontal lobe functional assessment functional magnetic resonance imaging human male occipital cortex Adolescent Adult Asperger Syndrome Autistic Disorder Brain Mapping Cerebral Cortex Delta Rhythm Electroencephalography Female Humans Male Nerve Net Neural Pathways Young Adult Barttfeld, P. Wicker, B. Cukier, S. Navarta, S. Lew, S. Sigman, M. A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections |
| topic_facet |
Autism Spectrum Disorder Delta band EEG Functional connectivity Resting state Small world metrics adolescent adult article autism brain function calculation clinical article controlled study disease severity electroencephalography female frontal lobe functional assessment functional magnetic resonance imaging human male occipital cortex Adolescent Adult Asperger Syndrome Autistic Disorder Brain Mapping Cerebral Cortex Delta Rhythm Electroencephalography Female Humans Male Nerve Net Neural Pathways Young Adult |
| description |
Over the last years, increasing evidence has fuelled the hypothesis that Autism Spectrum Disorder (ASD) is a condition of altered brain functional connectivity. The great majority of these empirical studies relies on functional magnetic resonance imaging (fMRI) which has a relatively poor temporal resolution. Only a handful of studies has examined networks emerging from dynamic coherence at the millisecond resolution and there are no investigations of coherence at the lowest frequencies in the power spectrum-which has recently been shown to reflect long-range cortico-cortical connections. Here we used electroencephalography (EEG) to assess dynamic brain connectivity in ASD focusing in the low-frequency (delta) range. We found that connectivity patterns were distinct in ASD and control populations and reflected a double dissociation: ASD subjects lacked long-range connections, with a most prominent deficit in fronto-occipital connections. Conversely, individuals with ASD showed increased short-range connections in lateral-frontal electrodes. This effect between categories showed a consistent parametric dependency: as ASD severity increased, short-range coherence was more pronounced and long-range coherence decreased. Theoretical arguments have been proposed arguing that distinct patterns of connectivity may result in networks with different efficiency in transmission of information. We show that the networks in ASD subjects have less Clustering coefficient, greater Characteristic Path Length than controls - indicating that the topology of the network departs from small-world behaviour - and greater modularity. Together these results show that delta-band coherence reveal qualitative and quantitative aspects associated with ASD pathology. © 2010 Elsevier Ltd. |
| format |
JOUR |
| author |
Barttfeld, P. Wicker, B. Cukier, S. Navarta, S. Lew, S. Sigman, M. |
| author_facet |
Barttfeld, P. Wicker, B. Cukier, S. Navarta, S. Lew, S. Sigman, M. |
| author_sort |
Barttfeld, P. |
| title |
A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections |
| title_short |
A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections |
| title_full |
A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections |
| title_fullStr |
A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections |
| title_full_unstemmed |
A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections |
| title_sort |
big-world network in asd: dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections |
| url |
http://hdl.handle.net/20.500.12110/paper_00283932_v49_n2_p254_Barttfeld |
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