Pituitary action of cytokines: Focus on BMP-4 and gp130 family

The anterior pituitary can develop benign tumors of different sizes, classified as micro- and macroadenomas, frequently associated with high levels of hormone production, leading to different associated syndromes like Cushing's disease, acromegaly or prolactinomas. Much work has been done in or...

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Autores principales:	Giacomini, D., Acuña, M., Gerez, J., Nagashima, A.C., Silberstein, S., Páez-Pereda, M., Labeur, M., Theodoropoulou, M., Renner, U., Stalla, G.K., Arzt, E.
Formato:	JOUR
Materias:	gp130 family Pituitary action of cytokines TGF-β family bone morphogenetic protein 4 cytokine glycoprotein gp 130 interleukin 6 retinoic acid acromegaly adenohypophysis adenohypophysis disease benign tumor carcinogenesis cell proliferation conference paper Cushing disease disease association disease course gene overexpression hormone release hormone synthesis human hypophysis cell hypophysis tumor in vivo study microadenoma nonhuman priority journal prolactinoma protein family signal transduction tumor classification tumor volume Animals Bone Morphogenetic Proteins Cytokine Receptor gp130 Cytokines Humans Models, Biological Multigene Family Pituitary Gland
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00283835_v85_n2_p94_Giacomini
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00283835_v85_n2_p94_Giacomini
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spelling	todo:paper_00283835_v85_n2_p94_Giacomini2023-10-03T14:38:58Z Pituitary action of cytokines: Focus on BMP-4 and gp130 family Giacomini, D. Acuña, M. Gerez, J. Nagashima, A.C. Silberstein, S. Páez-Pereda, M. Labeur, M. Theodoropoulou, M. Renner, U. Stalla, G.K. Arzt, E. gp130 family Pituitary action of cytokines TGF-β family bone morphogenetic protein 4 cytokine glycoprotein gp 130 interleukin 6 retinoic acid acromegaly adenohypophysis adenohypophysis disease benign tumor carcinogenesis cell proliferation conference paper Cushing disease disease association disease course gene overexpression hormone release hormone synthesis human hypophysis cell hypophysis tumor in vivo study microadenoma nonhuman priority journal prolactinoma protein family signal transduction tumor classification tumor volume Animals Bone Morphogenetic Proteins Cytokine Receptor gp130 Cytokines Humans Models, Biological Multigene Family Pituitary Gland The anterior pituitary can develop benign tumors of different sizes, classified as micro- and macroadenomas, frequently associated with high levels of hormone production, leading to different associated syndromes like Cushing's disease, acromegaly or prolactinomas. Much work has been done in order to understand the signaling pathways and the factors and hormones involved in the pituitary tumorigenic process. In recent years, much evidence has been collected and it is now well documented that cytokines of the gp130 family, such as interleukin-6, that use gp130 as a common signaling protein stimulate not only the proliferation but also the hormone secretion of pituitary cells. Experiments in vivo have shown that the overexpression of the gp130 receptor resulted in pituitary abnormal growth. Moreover, it has been recently described that bone morphogenetic protein-4 (BMP-4), a member of the TGF-β family, has a stimulatory role on lactosomatotropic cells promoting the development of prolactinomas but it has an inhibitory action on the corticotropic lineage. This inhibitory action prevents Cushing's disease progression. Furthermore, BMP-4 mediates the antiproliferative action of retinoic acid in these cells. The present review highlights the most recent work about gp130 and TGF-β cytokine families and their role in pituitary tumorigenesis. Copyright © 2007 S. Karger AG. Fil:Giacomini, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gerez, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Silberstein, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Páez-Pereda, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Labeur, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00283835_v85_n2_p94_Giacomini
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	gp130 family Pituitary action of cytokines TGF-β family bone morphogenetic protein 4 cytokine glycoprotein gp 130 interleukin 6 retinoic acid acromegaly adenohypophysis adenohypophysis disease benign tumor carcinogenesis cell proliferation conference paper Cushing disease disease association disease course gene overexpression hormone release hormone synthesis human hypophysis cell hypophysis tumor in vivo study microadenoma nonhuman priority journal prolactinoma protein family signal transduction tumor classification tumor volume Animals Bone Morphogenetic Proteins Cytokine Receptor gp130 Cytokines Humans Models, Biological Multigene Family Pituitary Gland
spellingShingle	gp130 family Pituitary action of cytokines TGF-β family bone morphogenetic protein 4 cytokine glycoprotein gp 130 interleukin 6 retinoic acid acromegaly adenohypophysis adenohypophysis disease benign tumor carcinogenesis cell proliferation conference paper Cushing disease disease association disease course gene overexpression hormone release hormone synthesis human hypophysis cell hypophysis tumor in vivo study microadenoma nonhuman priority journal prolactinoma protein family signal transduction tumor classification tumor volume Animals Bone Morphogenetic Proteins Cytokine Receptor gp130 Cytokines Humans Models, Biological Multigene Family Pituitary Gland Giacomini, D. Acuña, M. Gerez, J. Nagashima, A.C. Silberstein, S. Páez-Pereda, M. Labeur, M. Theodoropoulou, M. Renner, U. Stalla, G.K. Arzt, E. Pituitary action of cytokines: Focus on BMP-4 and gp130 family
topic_facet	gp130 family Pituitary action of cytokines TGF-β family bone morphogenetic protein 4 cytokine glycoprotein gp 130 interleukin 6 retinoic acid acromegaly adenohypophysis adenohypophysis disease benign tumor carcinogenesis cell proliferation conference paper Cushing disease disease association disease course gene overexpression hormone release hormone synthesis human hypophysis cell hypophysis tumor in vivo study microadenoma nonhuman priority journal prolactinoma protein family signal transduction tumor classification tumor volume Animals Bone Morphogenetic Proteins Cytokine Receptor gp130 Cytokines Humans Models, Biological Multigene Family Pituitary Gland
description	The anterior pituitary can develop benign tumors of different sizes, classified as micro- and macroadenomas, frequently associated with high levels of hormone production, leading to different associated syndromes like Cushing's disease, acromegaly or prolactinomas. Much work has been done in order to understand the signaling pathways and the factors and hormones involved in the pituitary tumorigenic process. In recent years, much evidence has been collected and it is now well documented that cytokines of the gp130 family, such as interleukin-6, that use gp130 as a common signaling protein stimulate not only the proliferation but also the hormone secretion of pituitary cells. Experiments in vivo have shown that the overexpression of the gp130 receptor resulted in pituitary abnormal growth. Moreover, it has been recently described that bone morphogenetic protein-4 (BMP-4), a member of the TGF-β family, has a stimulatory role on lactosomatotropic cells promoting the development of prolactinomas but it has an inhibitory action on the corticotropic lineage. This inhibitory action prevents Cushing's disease progression. Furthermore, BMP-4 mediates the antiproliferative action of retinoic acid in these cells. The present review highlights the most recent work about gp130 and TGF-β cytokine families and their role in pituitary tumorigenesis. Copyright © 2007 S. Karger AG.
format	JOUR
author	Giacomini, D. Acuña, M. Gerez, J. Nagashima, A.C. Silberstein, S. Páez-Pereda, M. Labeur, M. Theodoropoulou, M. Renner, U. Stalla, G.K. Arzt, E.
author_facet	Giacomini, D. Acuña, M. Gerez, J. Nagashima, A.C. Silberstein, S. Páez-Pereda, M. Labeur, M. Theodoropoulou, M. Renner, U. Stalla, G.K. Arzt, E.
author_sort	Giacomini, D.
title	Pituitary action of cytokines: Focus on BMP-4 and gp130 family
title_short	Pituitary action of cytokines: Focus on BMP-4 and gp130 family
title_full	Pituitary action of cytokines: Focus on BMP-4 and gp130 family
title_fullStr	Pituitary action of cytokines: Focus on BMP-4 and gp130 family
title_full_unstemmed	Pituitary action of cytokines: Focus on BMP-4 and gp130 family
title_sort	pituitary action of cytokines: focus on bmp-4 and gp130 family
url	http://hdl.handle.net/20.500.12110/paper_00283835_v85_n2_p94_Giacomini
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Pituitary action of cytokines: Focus on BMP-4 and gp130 family

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