DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation

During development of the rat anterior pituitary gland (APG) there is a fall in DNA replication which is accompanied by a decline in the activity of the soluble DNA polymerase and of an endonuclease. This latter enzyme is capable of activating the DNA template for the DNA polymerase assay. Sulpiride...

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Detalles Bibliográficos
Autores principales: Kalbermann, L.E., Szijan, I., Jahn, G.A., Krawiec, L., Burdman, J.A.
Formato: JOUR
Materias:
DNA synthesis
Pituitary gland
Prolactin
Sulpiride
dna polymerase
endonuclease
prolactin
sulpiride
thymidine kinase
adenohypophysis
animal experiment
dna synthesis
endocrine system
hypophysis
rat
Aging
Animals
Deoxyribonucleases
DNA
DNA Replication
DNA-Directed DNA Polymerase
Endonucleases
Pituitary Gland, Anterior
Rats
Thymidine Kinase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00283835_v29_n1_p42_Kalbermann
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:During development of the rat anterior pituitary gland (APG) there is a fall in DNA replication which is accompanied by a decline in the activity of the soluble DNA polymerase and of an endonuclease. This latter enzyme is capable of activating the DNA template for the DNA polymerase assay. Sulpiride sulfate, a drug known to produce prolactin release from the APG, increases thymidine incorporation in the APG 20 h after the injection. This drug also enhances the activity of the soluble DNA polymerase while that of the endonuclease and thymidine kinase does not change. The results suggest that the intracellular prolactin content regulates DNA replication in mammotrophs and that the soluble DNA polymerase plays an important role in this regulation. © 1979 S. Karger AG, Basel.

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