DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation
During development of the rat anterior pituitary gland (APG) there is a fall in DNA replication which is accompanied by a decline in the activity of the soluble DNA polymerase and of an endonuclease. This latter enzyme is capable of activating the DNA template for the DNA polymerase assay. Sulpiride...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00283835_v29_n1_p42_Kalbermann |
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todo:paper_00283835_v29_n1_p42_Kalbermann2023-10-03T14:38:47Z DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation Kalbermann, L.E. Szijan, I. Jahn, G.A. Krawiec, L. Burdman, J.A. DNA synthesis Pituitary gland Prolactin Sulpiride dna polymerase endonuclease prolactin sulpiride thymidine kinase adenohypophysis animal experiment dna synthesis endocrine system hypophysis rat Aging Animals Deoxyribonucleases DNA DNA Replication DNA-Directed DNA Polymerase Endonucleases Pituitary Gland, Anterior Rats Sulpiride Thymidine Kinase During development of the rat anterior pituitary gland (APG) there is a fall in DNA replication which is accompanied by a decline in the activity of the soluble DNA polymerase and of an endonuclease. This latter enzyme is capable of activating the DNA template for the DNA polymerase assay. Sulpiride sulfate, a drug known to produce prolactin release from the APG, increases thymidine incorporation in the APG 20 h after the injection. This drug also enhances the activity of the soluble DNA polymerase while that of the endonuclease and thymidine kinase does not change. The results suggest that the intracellular prolactin content regulates DNA replication in mammotrophs and that the soluble DNA polymerase plays an important role in this regulation. © 1979 S. Karger AG, Basel. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00283835_v29_n1_p42_Kalbermann |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
DNA synthesis Pituitary gland Prolactin Sulpiride dna polymerase endonuclease prolactin sulpiride thymidine kinase adenohypophysis animal experiment dna synthesis endocrine system hypophysis rat Aging Animals Deoxyribonucleases DNA DNA Replication DNA-Directed DNA Polymerase Endonucleases Pituitary Gland, Anterior Rats Sulpiride Thymidine Kinase |
| spellingShingle |
DNA synthesis Pituitary gland Prolactin Sulpiride dna polymerase endonuclease prolactin sulpiride thymidine kinase adenohypophysis animal experiment dna synthesis endocrine system hypophysis rat Aging Animals Deoxyribonucleases DNA DNA Replication DNA-Directed DNA Polymerase Endonucleases Pituitary Gland, Anterior Rats Sulpiride Thymidine Kinase Kalbermann, L.E. Szijan, I. Jahn, G.A. Krawiec, L. Burdman, J.A. DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation |
| topic_facet |
DNA synthesis Pituitary gland Prolactin Sulpiride dna polymerase endonuclease prolactin sulpiride thymidine kinase adenohypophysis animal experiment dna synthesis endocrine system hypophysis rat Aging Animals Deoxyribonucleases DNA DNA Replication DNA-Directed DNA Polymerase Endonucleases Pituitary Gland, Anterior Rats Sulpiride Thymidine Kinase |
| description |
During development of the rat anterior pituitary gland (APG) there is a fall in DNA replication which is accompanied by a decline in the activity of the soluble DNA polymerase and of an endonuclease. This latter enzyme is capable of activating the DNA template for the DNA polymerase assay. Sulpiride sulfate, a drug known to produce prolactin release from the APG, increases thymidine incorporation in the APG 20 h after the injection. This drug also enhances the activity of the soluble DNA polymerase while that of the endonuclease and thymidine kinase does not change. The results suggest that the intracellular prolactin content regulates DNA replication in mammotrophs and that the soluble DNA polymerase plays an important role in this regulation. © 1979 S. Karger AG, Basel. |
| format |
JOUR |
| author |
Kalbermann, L.E. Szijan, I. Jahn, G.A. Krawiec, L. Burdman, J.A. |
| author_facet |
Kalbermann, L.E. Szijan, I. Jahn, G.A. Krawiec, L. Burdman, J.A. |
| author_sort |
Kalbermann, L.E. |
| title |
DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation |
| title_short |
DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation |
| title_full |
DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation |
| title_fullStr |
DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation |
| title_full_unstemmed |
DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation |
| title_sort |
dna synthesis in the pituitary gland of the rat: effect of sulpiride and postnatal maturation |
| url |
http://hdl.handle.net/20.500.12110/paper_00283835_v29_n1_p42_Kalbermann |
| work_keys_str_mv |
AT kalbermannle dnasynthesisinthepituitaryglandoftherateffectofsulpirideandpostnatalmaturation AT szijani dnasynthesisinthepituitaryglandoftherateffectofsulpirideandpostnatalmaturation AT jahnga dnasynthesisinthepituitaryglandoftherateffectofsulpirideandpostnatalmaturation AT krawiecl dnasynthesisinthepituitaryglandoftherateffectofsulpirideandpostnatalmaturation AT burdmanja dnasynthesisinthepituitaryglandoftherateffectofsulpirideandpostnatalmaturation |
| _version_ |
1807323641894928384 |