Effects of castration and reproductive hormones on pineal serotonin metabolism in rats
The effects of reproductive hormones on pineal serotonin (5-HT) metabolism were examined in castrated rats. Castration of males but not of females increased 5-HT content, whereas follicle-stimulating hormone (FSH) and luteinizing hormone (LH) augmented, and testosterone (T) decreased, pineal 5-HT co...
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todo:paper_00283835_v28_n3_p187_Vacas2023-10-03T14:38:46Z Effects of castration and reproductive hormones on pineal serotonin metabolism in rats Vacas, M.I. Cardinal, D.P. Estradiol FSH LH Pineal gland Prolactin Serotonin metabolism Superior cervical ganglion Testosterone amine oxidase (flavin containing) estradiol fenclonine follitropin gonadotropin luteinizing hormone prolactin radioisotope steroid hormone testosterone animal experiment castration central nervous system drug comparison drug screening endocrine system female genital system gonadectomy male genital system phenethylamine c 14 pineal body rat serotonin c 14 sex superior cervical ganglionectomy Animal Castration Comparative Study Estradiol Female Fenclonine Follicle Stimulating Hormone Ganglia, Autonomic Gonadotropins, Pituitary Luteinizing Hormone Male Monoamine Oxidase Pineal Gland Prolactin Rats Serotonin Testosterone The effects of reproductive hormones on pineal serotonin (5-HT) metabolism were examined in castrated rats. Castration of males but not of females increased 5-HT content, whereas follicle-stimulating hormone (FSH) and luteinizing hormone (LH) augmented, and testosterone (T) decreased, pineal 5-HT concentration of orchidectomized rats. In males castration slowed the rate of decline of pineal amine concentration following the injection of p-chlorophenylalanine (PCPA). The administration of T, FSH or LH brought about significant acceleration of pineal 5-HT turnover rate. In spayed rats estradiol treatment decreased 5-HT decline following PCPA. Pineal monoamine oxidase (MAO) activity type B (assaying by using β-phenylethylamine as substrate) was increased by T injection whereas estradiol diminished MAO type A activity (assaying by using 5-HT as substrate). The administration of prolactin to castrated male rats resulted in depression of both types of MAO activity while LH and FSH reduced the activity of MAO type B. The injection of T to rats subjected to superior cervical ganglionectomy counteracted partially the depressed pineal 5-HT levels caused by surgical manipulation. LH or FSH also augmented pineal 5-HT concentration in ganglion-ectomized rats. Bilateral decentralization of ganglia abolished hormone effects on amine levels. These results offer additional support to previous observations indicating that the pineal gland and its innervating sympathetic neurons are effector tissues for reproductive hormones. © 1979 S. Karger AG, Basel. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00283835_v28_n3_p187_Vacas |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Estradiol FSH LH Pineal gland Prolactin Serotonin metabolism Superior cervical ganglion Testosterone amine oxidase (flavin containing) estradiol fenclonine follitropin gonadotropin luteinizing hormone prolactin radioisotope steroid hormone testosterone animal experiment castration central nervous system drug comparison drug screening endocrine system female genital system gonadectomy male genital system phenethylamine c 14 pineal body rat serotonin c 14 sex superior cervical ganglionectomy Animal Castration Comparative Study Estradiol Female Fenclonine Follicle Stimulating Hormone Ganglia, Autonomic Gonadotropins, Pituitary Luteinizing Hormone Male Monoamine Oxidase Pineal Gland Prolactin Rats Serotonin Testosterone |
| spellingShingle |
Estradiol FSH LH Pineal gland Prolactin Serotonin metabolism Superior cervical ganglion Testosterone amine oxidase (flavin containing) estradiol fenclonine follitropin gonadotropin luteinizing hormone prolactin radioisotope steroid hormone testosterone animal experiment castration central nervous system drug comparison drug screening endocrine system female genital system gonadectomy male genital system phenethylamine c 14 pineal body rat serotonin c 14 sex superior cervical ganglionectomy Animal Castration Comparative Study Estradiol Female Fenclonine Follicle Stimulating Hormone Ganglia, Autonomic Gonadotropins, Pituitary Luteinizing Hormone Male Monoamine Oxidase Pineal Gland Prolactin Rats Serotonin Testosterone Vacas, M.I. Cardinal, D.P. Effects of castration and reproductive hormones on pineal serotonin metabolism in rats |
| topic_facet |
Estradiol FSH LH Pineal gland Prolactin Serotonin metabolism Superior cervical ganglion Testosterone amine oxidase (flavin containing) estradiol fenclonine follitropin gonadotropin luteinizing hormone prolactin radioisotope steroid hormone testosterone animal experiment castration central nervous system drug comparison drug screening endocrine system female genital system gonadectomy male genital system phenethylamine c 14 pineal body rat serotonin c 14 sex superior cervical ganglionectomy Animal Castration Comparative Study Estradiol Female Fenclonine Follicle Stimulating Hormone Ganglia, Autonomic Gonadotropins, Pituitary Luteinizing Hormone Male Monoamine Oxidase Pineal Gland Prolactin Rats Serotonin Testosterone |
| description |
The effects of reproductive hormones on pineal serotonin (5-HT) metabolism were examined in castrated rats. Castration of males but not of females increased 5-HT content, whereas follicle-stimulating hormone (FSH) and luteinizing hormone (LH) augmented, and testosterone (T) decreased, pineal 5-HT concentration of orchidectomized rats. In males castration slowed the rate of decline of pineal amine concentration following the injection of p-chlorophenylalanine (PCPA). The administration of T, FSH or LH brought about significant acceleration of pineal 5-HT turnover rate. In spayed rats estradiol treatment decreased 5-HT decline following PCPA. Pineal monoamine oxidase (MAO) activity type B (assaying by using β-phenylethylamine as substrate) was increased by T injection whereas estradiol diminished MAO type A activity (assaying by using 5-HT as substrate). The administration of prolactin to castrated male rats resulted in depression of both types of MAO activity while LH and FSH reduced the activity of MAO type B. The injection of T to rats subjected to superior cervical ganglionectomy counteracted partially the depressed pineal 5-HT levels caused by surgical manipulation. LH or FSH also augmented pineal 5-HT concentration in ganglion-ectomized rats. Bilateral decentralization of ganglia abolished hormone effects on amine levels. These results offer additional support to previous observations indicating that the pineal gland and its innervating sympathetic neurons are effector tissues for reproductive hormones. © 1979 S. Karger AG, Basel. |
| format |
JOUR |
| author |
Vacas, M.I. Cardinal, D.P. |
| author_facet |
Vacas, M.I. Cardinal, D.P. |
| author_sort |
Vacas, M.I. |
| title |
Effects of castration and reproductive hormones on pineal serotonin metabolism in rats |
| title_short |
Effects of castration and reproductive hormones on pineal serotonin metabolism in rats |
| title_full |
Effects of castration and reproductive hormones on pineal serotonin metabolism in rats |
| title_fullStr |
Effects of castration and reproductive hormones on pineal serotonin metabolism in rats |
| title_full_unstemmed |
Effects of castration and reproductive hormones on pineal serotonin metabolism in rats |
| title_sort |
effects of castration and reproductive hormones on pineal serotonin metabolism in rats |
| url |
http://hdl.handle.net/20.500.12110/paper_00283835_v28_n3_p187_Vacas |
| work_keys_str_mv |
AT vacasmi effectsofcastrationandreproductivehormonesonpinealserotoninmetabolisminrats AT cardinaldp effectsofcastrationandreproductivehormonesonpinealserotoninmetabolisminrats |
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1807324288897777664 |