Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those fromEurope, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Co...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00280836_v514_n7253_p494_Bos |
| Aporte de: |
| id |
todo:paper_00280836_v514_n7253_p494_Bos |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_00280836_v514_n7253_p494_Bos2023-10-03T14:38:36Z Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis Bos, K.I. Harkins, K.M. Herbig, A. Coscolla, M. Weber, N. Comas, I. Forrest, S.A. Bryant, J.M. Harris, S.R. Schuenemann, V.J. Campbell, T.J. Majander, K. Wilbur, A.K. Guichon, R.A. Steadman, D.L.W. Cook, D.C. Niemann, S. Behr, M.A. Zumarraga, M. Bastida, R. Huson, D. Nieselt, K. Young, D. Parkhill, J. Buikstra, J.E. Gagneux, S. Stone, A.C. Krause, J. adaptation bacterium common ancestry disease spread disease transmission genome geographical distribution Holocene pinniped Pleistocene skeleton tuberculosis Article bacterial genome bacterial transmission bacterium identification DNA damage DNA library Holocene human human tissue mutation rate Mycobacterium tuberculosis nonhuman Peruvian phylogeny population size priority journal single nucleotide polymorphism tuberculosis animal bacterial genome bone ethnology Europe genetics genomics history microbiology migration Mycobacterium tuberculosis Peru seal transmission tuberculosis zoonosis Pinnipedia Europe United States Mammalia Mycobacterium tuberculosis Otariidae Animals Bone and Bones Europe Genome, Bacterial Genomics History, Ancient Human Migration Humans Mycobacterium tuberculosis Peru Phylogeny Pinnipedia Tuberculosis Zoonoses Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those fromEurope, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-oldmycobacterial genomesfromPeruvianhuman skeletons, revealing that amember of the M. tuberculosis complex caused human disease before contact.The ancient strains are distinct fromknownhuman-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean. © 2014 Macmillan Publishers Limited. All rights reserved. Fil:Zumarraga, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00280836_v514_n7253_p494_Bos |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
adaptation bacterium common ancestry disease spread disease transmission genome geographical distribution Holocene pinniped Pleistocene skeleton tuberculosis Article bacterial genome bacterial transmission bacterium identification DNA damage DNA library Holocene human human tissue mutation rate Mycobacterium tuberculosis nonhuman Peruvian phylogeny population size priority journal single nucleotide polymorphism tuberculosis animal bacterial genome bone ethnology Europe genetics genomics history microbiology migration Mycobacterium tuberculosis Peru seal transmission tuberculosis zoonosis Pinnipedia Europe United States Mammalia Mycobacterium tuberculosis Otariidae Animals Bone and Bones Europe Genome, Bacterial Genomics History, Ancient Human Migration Humans Mycobacterium tuberculosis Peru Phylogeny Pinnipedia Tuberculosis Zoonoses |
| spellingShingle |
adaptation bacterium common ancestry disease spread disease transmission genome geographical distribution Holocene pinniped Pleistocene skeleton tuberculosis Article bacterial genome bacterial transmission bacterium identification DNA damage DNA library Holocene human human tissue mutation rate Mycobacterium tuberculosis nonhuman Peruvian phylogeny population size priority journal single nucleotide polymorphism tuberculosis animal bacterial genome bone ethnology Europe genetics genomics history microbiology migration Mycobacterium tuberculosis Peru seal transmission tuberculosis zoonosis Pinnipedia Europe United States Mammalia Mycobacterium tuberculosis Otariidae Animals Bone and Bones Europe Genome, Bacterial Genomics History, Ancient Human Migration Humans Mycobacterium tuberculosis Peru Phylogeny Pinnipedia Tuberculosis Zoonoses Bos, K.I. Harkins, K.M. Herbig, A. Coscolla, M. Weber, N. Comas, I. Forrest, S.A. Bryant, J.M. Harris, S.R. Schuenemann, V.J. Campbell, T.J. Majander, K. Wilbur, A.K. Guichon, R.A. Steadman, D.L.W. Cook, D.C. Niemann, S. Behr, M.A. Zumarraga, M. Bastida, R. Huson, D. Nieselt, K. Young, D. Parkhill, J. Buikstra, J.E. Gagneux, S. Stone, A.C. Krause, J. Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| topic_facet |
adaptation bacterium common ancestry disease spread disease transmission genome geographical distribution Holocene pinniped Pleistocene skeleton tuberculosis Article bacterial genome bacterial transmission bacterium identification DNA damage DNA library Holocene human human tissue mutation rate Mycobacterium tuberculosis nonhuman Peruvian phylogeny population size priority journal single nucleotide polymorphism tuberculosis animal bacterial genome bone ethnology Europe genetics genomics history microbiology migration Mycobacterium tuberculosis Peru seal transmission tuberculosis zoonosis Pinnipedia Europe United States Mammalia Mycobacterium tuberculosis Otariidae Animals Bone and Bones Europe Genome, Bacterial Genomics History, Ancient Human Migration Humans Mycobacterium tuberculosis Peru Phylogeny Pinnipedia Tuberculosis Zoonoses |
| description |
Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those fromEurope, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-oldmycobacterial genomesfromPeruvianhuman skeletons, revealing that amember of the M. tuberculosis complex caused human disease before contact.The ancient strains are distinct fromknownhuman-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean. © 2014 Macmillan Publishers Limited. All rights reserved. |
| format |
JOUR |
| author |
Bos, K.I. Harkins, K.M. Herbig, A. Coscolla, M. Weber, N. Comas, I. Forrest, S.A. Bryant, J.M. Harris, S.R. Schuenemann, V.J. Campbell, T.J. Majander, K. Wilbur, A.K. Guichon, R.A. Steadman, D.L.W. Cook, D.C. Niemann, S. Behr, M.A. Zumarraga, M. Bastida, R. Huson, D. Nieselt, K. Young, D. Parkhill, J. Buikstra, J.E. Gagneux, S. Stone, A.C. Krause, J. |
| author_facet |
Bos, K.I. Harkins, K.M. Herbig, A. Coscolla, M. Weber, N. Comas, I. Forrest, S.A. Bryant, J.M. Harris, S.R. Schuenemann, V.J. Campbell, T.J. Majander, K. Wilbur, A.K. Guichon, R.A. Steadman, D.L.W. Cook, D.C. Niemann, S. Behr, M.A. Zumarraga, M. Bastida, R. Huson, D. Nieselt, K. Young, D. Parkhill, J. Buikstra, J.E. Gagneux, S. Stone, A.C. Krause, J. |
| author_sort |
Bos, K.I. |
| title |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| title_short |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| title_full |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| title_fullStr |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| title_full_unstemmed |
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis |
| title_sort |
pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis |
| url |
http://hdl.handle.net/20.500.12110/paper_00280836_v514_n7253_p494_Bos |
| work_keys_str_mv |
AT boski precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT harkinskm precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT herbiga precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT coscollam precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT webern precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT comasi precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT forrestsa precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT bryantjm precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT harrissr precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT schuenemannvj precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT campbelltj precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT majanderk precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT wilburak precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT guichonra precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT steadmandlw precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT cookdc precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT niemanns precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT behrma precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT zumarragam precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT bastidar precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT husond precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT nieseltk precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT youngd precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT parkhillj precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT buikstraje precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT gagneuxs precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT stoneac precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis AT krausej precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis |
| _version_ |
1807320314870235136 |