Signature of consciousness in the dynamics of resting-state brain activity
At rest, the brain is traversed by spontaneous functional connectivity patterns. Two hypotheses have been proposed for their origins: they may reflect a continuous stream of ongoing cognitive processes as well as random fluctuations shaped by a fixed anatomical connectivity matrix. Here we show that...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00278424_v112_n3_p887_Barttfelda |
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todo:paper_00278424_v112_n3_p887_Barttfelda2023-10-03T14:38:12Z Signature of consciousness in the dynamics of resting-state brain activity Barttfelda, P. Uhriga, L. Sitta, J.D. Sigmane, M. Jarrayaa, B. Dehaene, S. Anesthesia Consciousness Dynamics Functional connectivity Structural connectivity anatomical concepts anesthesia animal experiment Article brain region consciousness electroencephalogram female functional magnetic resonance imaging image analysis male nonhuman priority journal resting state network theory wakefulness animal brain brain mapping nuclear magnetic resonance imaging physiology rhesus monkey Animals Brain Brain Mapping Consciousness Macaca mulatta Magnetic Resonance Imaging At rest, the brain is traversed by spontaneous functional connectivity patterns. Two hypotheses have been proposed for their origins: they may reflect a continuous stream of ongoing cognitive processes as well as random fluctuations shaped by a fixed anatomical connectivity matrix. Here we show that both sources contribute to the shaping of resting-state networks, yet with distinct contributions during consciousness and anesthesia. We measured dynamical functional connectivity with functional MRI during the resting state in awake and anesthetized monkeys. Under anesthesia, the more frequent functional connectivity patterns inherit the structure of anatomical connectivity, exhibit fewer small-world properties, and lack negative correlations. Conversely, wakefulness is characterized by the sequential exploration of a richer repertoire of functional configurations, often dissimilar to anatomical structure, and comprising positive and negative correlations among brain regions. These results reconcile theories of consciousness with observations of long-range correlation in the anesthetized brain and show that a rich functional dynamics might constitute a signature of consciousness, with potential clinical implications for the detection of awareness in anesthesia and brain-lesioned patients. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00278424_v112_n3_p887_Barttfelda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Anesthesia Consciousness Dynamics Functional connectivity Structural connectivity anatomical concepts anesthesia animal experiment Article brain region consciousness electroencephalogram female functional magnetic resonance imaging image analysis male nonhuman priority journal resting state network theory wakefulness animal brain brain mapping nuclear magnetic resonance imaging physiology rhesus monkey Animals Brain Brain Mapping Consciousness Macaca mulatta Magnetic Resonance Imaging |
| spellingShingle |
Anesthesia Consciousness Dynamics Functional connectivity Structural connectivity anatomical concepts anesthesia animal experiment Article brain region consciousness electroencephalogram female functional magnetic resonance imaging image analysis male nonhuman priority journal resting state network theory wakefulness animal brain brain mapping nuclear magnetic resonance imaging physiology rhesus monkey Animals Brain Brain Mapping Consciousness Macaca mulatta Magnetic Resonance Imaging Barttfelda, P. Uhriga, L. Sitta, J.D. Sigmane, M. Jarrayaa, B. Dehaene, S. Signature of consciousness in the dynamics of resting-state brain activity |
| topic_facet |
Anesthesia Consciousness Dynamics Functional connectivity Structural connectivity anatomical concepts anesthesia animal experiment Article brain region consciousness electroencephalogram female functional magnetic resonance imaging image analysis male nonhuman priority journal resting state network theory wakefulness animal brain brain mapping nuclear magnetic resonance imaging physiology rhesus monkey Animals Brain Brain Mapping Consciousness Macaca mulatta Magnetic Resonance Imaging |
| description |
At rest, the brain is traversed by spontaneous functional connectivity patterns. Two hypotheses have been proposed for their origins: they may reflect a continuous stream of ongoing cognitive processes as well as random fluctuations shaped by a fixed anatomical connectivity matrix. Here we show that both sources contribute to the shaping of resting-state networks, yet with distinct contributions during consciousness and anesthesia. We measured dynamical functional connectivity with functional MRI during the resting state in awake and anesthetized monkeys. Under anesthesia, the more frequent functional connectivity patterns inherit the structure of anatomical connectivity, exhibit fewer small-world properties, and lack negative correlations. Conversely, wakefulness is characterized by the sequential exploration of a richer repertoire of functional configurations, often dissimilar to anatomical structure, and comprising positive and negative correlations among brain regions. These results reconcile theories of consciousness with observations of long-range correlation in the anesthetized brain and show that a rich functional dynamics might constitute a signature of consciousness, with potential clinical implications for the detection of awareness in anesthesia and brain-lesioned patients. |
| format |
JOUR |
| author |
Barttfelda, P. Uhriga, L. Sitta, J.D. Sigmane, M. Jarrayaa, B. Dehaene, S. |
| author_facet |
Barttfelda, P. Uhriga, L. Sitta, J.D. Sigmane, M. Jarrayaa, B. Dehaene, S. |
| author_sort |
Barttfelda, P. |
| title |
Signature of consciousness in the dynamics of resting-state brain activity |
| title_short |
Signature of consciousness in the dynamics of resting-state brain activity |
| title_full |
Signature of consciousness in the dynamics of resting-state brain activity |
| title_fullStr |
Signature of consciousness in the dynamics of resting-state brain activity |
| title_full_unstemmed |
Signature of consciousness in the dynamics of resting-state brain activity |
| title_sort |
signature of consciousness in the dynamics of resting-state brain activity |
| url |
http://hdl.handle.net/20.500.12110/paper_00278424_v112_n3_p887_Barttfelda |
| work_keys_str_mv |
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