Molecular mechanisms of action of some immunosuppresive drugs
A number of natural and synthetic substances are used in the treatment of immunological disorders. The immunosuppressive drugs are widely utilized in clinical treatments of autoimmune disorders, in the prevention of transplant rejection as well as in non-autoimmune diseases such as allergy. The desi...
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todo:paper_00257680_v68_n6_p455_Liberman2023-10-03T14:36:46Z Molecular mechanisms of action of some immunosuppresive drugs Liberman, A.C. Druker, J. Refojo, D. Arzt, E. Corticosteroids Immunosuppressive drugs T cells antibody antiinflammatory agent azathioprine basiliximab calcineurin inhibitor corticosteroid cyclophosphamide cyclosporin A cytotoxic agent daclizumab immunosuppressive agent leflunomide mycophenolic acid 2 morpholinoethyl ester OKT 3 rapamycin steroid tacrolimus antiinflammatory agent corticosteroid immunosuppressive agent allergy article autoimmune disease drug mechanism drug targeting graft rejection human immune response immunomodulation immunopathology molecular mechanics mononuclear cell pathophysiology T lymphocyte animal autoimmune disease drug effect immune system Adrenal Cortex Hormones Animals Anti-Inflammatory Agents Autoimmune Diseases Humans Immune System Immunosuppressive Agents A number of natural and synthetic substances are used in the treatment of immunological disorders. The immunosuppressive drugs are widely utilized in clinical treatments of autoimmune disorders, in the prevention of transplant rejection as well as in non-autoimmune diseases such as allergy. The design of immunosuppressive therapies is based on the control of the exacerbated immune response. The pathophysiologic mean of this concept is to modulate the action of mononuclear cells, being T cells the main targets. Immunosuppressive agents have different molecular targets, and an important drawback in their use is that they also inhibit the normal immune system response. Depending on their mode of action, immunosuppressive drugs can be classified in four different groups: antinflammatory drugs of the corticosteroid family, inhibitors of the calcineurin pathway, cytototoxic or antiproliferative drugs and specific antibodies. In this article, we focus on the molecular action of immunosuppressive drugs such as steroids, cyclosporine, tacrolimus, azathioprine, cyclophosphamide, sirolimus, mycophenolate mofetil, leflunomide and specific antibodies, providing data to characterize and improve the use of these agents. Fil:Liberman, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Druker, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Refojo, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00257680_v68_n6_p455_Liberman |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Corticosteroids Immunosuppressive drugs T cells antibody antiinflammatory agent azathioprine basiliximab calcineurin inhibitor corticosteroid cyclophosphamide cyclosporin A cytotoxic agent daclizumab immunosuppressive agent leflunomide mycophenolic acid 2 morpholinoethyl ester OKT 3 rapamycin steroid tacrolimus antiinflammatory agent corticosteroid immunosuppressive agent allergy article autoimmune disease drug mechanism drug targeting graft rejection human immune response immunomodulation immunopathology molecular mechanics mononuclear cell pathophysiology T lymphocyte animal autoimmune disease drug effect immune system Adrenal Cortex Hormones Animals Anti-Inflammatory Agents Autoimmune Diseases Humans Immune System Immunosuppressive Agents |
| spellingShingle |
Corticosteroids Immunosuppressive drugs T cells antibody antiinflammatory agent azathioprine basiliximab calcineurin inhibitor corticosteroid cyclophosphamide cyclosporin A cytotoxic agent daclizumab immunosuppressive agent leflunomide mycophenolic acid 2 morpholinoethyl ester OKT 3 rapamycin steroid tacrolimus antiinflammatory agent corticosteroid immunosuppressive agent allergy article autoimmune disease drug mechanism drug targeting graft rejection human immune response immunomodulation immunopathology molecular mechanics mononuclear cell pathophysiology T lymphocyte animal autoimmune disease drug effect immune system Adrenal Cortex Hormones Animals Anti-Inflammatory Agents Autoimmune Diseases Humans Immune System Immunosuppressive Agents Liberman, A.C. Druker, J. Refojo, D. Arzt, E. Molecular mechanisms of action of some immunosuppresive drugs |
| topic_facet |
Corticosteroids Immunosuppressive drugs T cells antibody antiinflammatory agent azathioprine basiliximab calcineurin inhibitor corticosteroid cyclophosphamide cyclosporin A cytotoxic agent daclizumab immunosuppressive agent leflunomide mycophenolic acid 2 morpholinoethyl ester OKT 3 rapamycin steroid tacrolimus antiinflammatory agent corticosteroid immunosuppressive agent allergy article autoimmune disease drug mechanism drug targeting graft rejection human immune response immunomodulation immunopathology molecular mechanics mononuclear cell pathophysiology T lymphocyte animal autoimmune disease drug effect immune system Adrenal Cortex Hormones Animals Anti-Inflammatory Agents Autoimmune Diseases Humans Immune System Immunosuppressive Agents |
| description |
A number of natural and synthetic substances are used in the treatment of immunological disorders. The immunosuppressive drugs are widely utilized in clinical treatments of autoimmune disorders, in the prevention of transplant rejection as well as in non-autoimmune diseases such as allergy. The design of immunosuppressive therapies is based on the control of the exacerbated immune response. The pathophysiologic mean of this concept is to modulate the action of mononuclear cells, being T cells the main targets. Immunosuppressive agents have different molecular targets, and an important drawback in their use is that they also inhibit the normal immune system response. Depending on their mode of action, immunosuppressive drugs can be classified in four different groups: antinflammatory drugs of the corticosteroid family, inhibitors of the calcineurin pathway, cytototoxic or antiproliferative drugs and specific antibodies. In this article, we focus on the molecular action of immunosuppressive drugs such as steroids, cyclosporine, tacrolimus, azathioprine, cyclophosphamide, sirolimus, mycophenolate mofetil, leflunomide and specific antibodies, providing data to characterize and improve the use of these agents. |
| format |
JOUR |
| author |
Liberman, A.C. Druker, J. Refojo, D. Arzt, E. |
| author_facet |
Liberman, A.C. Druker, J. Refojo, D. Arzt, E. |
| author_sort |
Liberman, A.C. |
| title |
Molecular mechanisms of action of some immunosuppresive drugs |
| title_short |
Molecular mechanisms of action of some immunosuppresive drugs |
| title_full |
Molecular mechanisms of action of some immunosuppresive drugs |
| title_fullStr |
Molecular mechanisms of action of some immunosuppresive drugs |
| title_full_unstemmed |
Molecular mechanisms of action of some immunosuppresive drugs |
| title_sort |
molecular mechanisms of action of some immunosuppresive drugs |
| url |
http://hdl.handle.net/20.500.12110/paper_00257680_v68_n6_p455_Liberman |
| work_keys_str_mv |
AT libermanac molecularmechanismsofactionofsomeimmunosuppresivedrugs AT drukerj molecularmechanismsofactionofsomeimmunosuppresivedrugs AT refojod molecularmechanismsofactionofsomeimmunosuppresivedrugs AT arzte molecularmechanismsofactionofsomeimmunosuppresivedrugs |
| _version_ |
1807322041253101568 |