Synthetic oligonucleotides and their application in gene therapy
Synthetic oligonucleotides are useful for research in molecular biology, for clinical diagnosis and for the development of new therapeutic agents. In fact, their application to gene therapy has given rise to a new field termed antisense, enabling the synthesis of a new generation of drugs. The proce...
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00257680_v55_n3_p263_Iribarren |
| Aporte de: |
| id |
todo:paper_00257680_v55_n3_p263_Iribarren |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_00257680_v55_n3_p263_Iribarren2023-10-03T14:36:30Z Synthetic oligonucleotides and their application in gene therapy Iribarren, A.M. antineoplastic agent antisense oligonucleotide antivirus agent oligonucleotide antisense oligonucleotide gene expression gene therapy human short survey animal article chemistry methodology mouse Animals Gene Therapy Humans Mice Oligonucleotides, Antisense Synthetic oligonucleotides are useful for research in molecular biology, for clinical diagnosis and for the development of new therapeutic agents. In fact, their application to gene therapy has given rise to a new field termed antisense, enabling the synthesis of a new generation of drugs. The procedure is based on coupling an oligonucleotide with mRNA to yield the protein whose production by the host is to be prevented, and thus through diverse pathways inhibiting gene expression. In medicine, a start has been made by applying antisense techniques in human drug trials, particularly as antiviral and antileukemic agents. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00257680_v55_n3_p263_Iribarren |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
antineoplastic agent antisense oligonucleotide antivirus agent oligonucleotide antisense oligonucleotide gene expression gene therapy human short survey animal article chemistry methodology mouse Animals Gene Therapy Humans Mice Oligonucleotides, Antisense |
| spellingShingle |
antineoplastic agent antisense oligonucleotide antivirus agent oligonucleotide antisense oligonucleotide gene expression gene therapy human short survey animal article chemistry methodology mouse Animals Gene Therapy Humans Mice Oligonucleotides, Antisense Iribarren, A.M. Synthetic oligonucleotides and their application in gene therapy |
| topic_facet |
antineoplastic agent antisense oligonucleotide antivirus agent oligonucleotide antisense oligonucleotide gene expression gene therapy human short survey animal article chemistry methodology mouse Animals Gene Therapy Humans Mice Oligonucleotides, Antisense |
| description |
Synthetic oligonucleotides are useful for research in molecular biology, for clinical diagnosis and for the development of new therapeutic agents. In fact, their application to gene therapy has given rise to a new field termed antisense, enabling the synthesis of a new generation of drugs. The procedure is based on coupling an oligonucleotide with mRNA to yield the protein whose production by the host is to be prevented, and thus through diverse pathways inhibiting gene expression. In medicine, a start has been made by applying antisense techniques in human drug trials, particularly as antiviral and antileukemic agents. |
| format |
JOUR |
| author |
Iribarren, A.M. |
| author_facet |
Iribarren, A.M. |
| author_sort |
Iribarren, A.M. |
| title |
Synthetic oligonucleotides and their application in gene therapy |
| title_short |
Synthetic oligonucleotides and their application in gene therapy |
| title_full |
Synthetic oligonucleotides and their application in gene therapy |
| title_fullStr |
Synthetic oligonucleotides and their application in gene therapy |
| title_full_unstemmed |
Synthetic oligonucleotides and their application in gene therapy |
| title_sort |
synthetic oligonucleotides and their application in gene therapy |
| url |
http://hdl.handle.net/20.500.12110/paper_00257680_v55_n3_p263_Iribarren |
| work_keys_str_mv |
AT iribarrenam syntheticoligonucleotidesandtheirapplicationingenetherapy |
| _version_ |
1807322987991400448 |