Mechanisms of action of endothelin-i in rat adrenal
Displacement curves of 125I-Endothelin-1 (ET-1) binding to rat adrenal cells with unlabeled ET-1, and the ET-1 receptor-related peptides sarafotoxin and BQ-123, show that rat adrenal cortex possess, as its bovine counterpart, two different receptors to ET-1 named ET-A and ET-B. Binding of ET-1 to it...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00243205_v63_n15_p1315_Pecci |
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todo:paper_00243205_v63_n15_p1315_Pecci2023-10-03T14:34:41Z Mechanisms of action of endothelin-i in rat adrenal Pecci, A. Romero, D.G. Lantos, C.P. Cozza, E.N. Adrenal cells Aldosterone Endothelin-1 1 (5 isoquinolinesulfonyl) 2 methylpiperazine aldosterone calcium 45 calcium channel corticotropin cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin A receptor endothelin B receptor iodine 125 ouabain sarafotoxin S6b adrenal cortex adrenal gland animal tissue article controlled study negative feedback nonhuman rat renin angiotensin aldosterone system zona glomerulosa Displacement curves of 125I-Endothelin-1 (ET-1) binding to rat adrenal cells with unlabeled ET-1, and the ET-1 receptor-related peptides sarafotoxin and BQ-123, show that rat adrenal cortex possess, as its bovine counterpart, two different receptors to ET-1 named ET-A and ET-B. Binding of ET-1 to its rat adrenal receptors stimulates i) aldosterone production, in vivo and in vitro ii) calcium influx, which is mediated through voltage dependent- and receptor operated- calcium channels, iii) cholesterol uptake, iv) stimulation of Na+/K+-ATPase and iv) diacylglycerol production. While the last effect is mediated through ET-A receptors the others involve binding of ET-1 to ET-B receptors. Finally, ouabain potentiates the ET-1-mediated stimulation of aldosterone production, suggesting that the effect of the peptidic hormone on Na+/K+-ATPase could act as a negative feedback mechanism. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00243205_v63_n15_p1315_Pecci |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Adrenal cells Aldosterone Endothelin-1 1 (5 isoquinolinesulfonyl) 2 methylpiperazine aldosterone calcium 45 calcium channel corticotropin cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin A receptor endothelin B receptor iodine 125 ouabain sarafotoxin S6b adrenal cortex adrenal gland animal tissue article controlled study negative feedback nonhuman rat renin angiotensin aldosterone system zona glomerulosa |
| spellingShingle |
Adrenal cells Aldosterone Endothelin-1 1 (5 isoquinolinesulfonyl) 2 methylpiperazine aldosterone calcium 45 calcium channel corticotropin cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin A receptor endothelin B receptor iodine 125 ouabain sarafotoxin S6b adrenal cortex adrenal gland animal tissue article controlled study negative feedback nonhuman rat renin angiotensin aldosterone system zona glomerulosa Pecci, A. Romero, D.G. Lantos, C.P. Cozza, E.N. Mechanisms of action of endothelin-i in rat adrenal |
| topic_facet |
Adrenal cells Aldosterone Endothelin-1 1 (5 isoquinolinesulfonyl) 2 methylpiperazine aldosterone calcium 45 calcium channel corticotropin cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin A receptor endothelin B receptor iodine 125 ouabain sarafotoxin S6b adrenal cortex adrenal gland animal tissue article controlled study negative feedback nonhuman rat renin angiotensin aldosterone system zona glomerulosa |
| description |
Displacement curves of 125I-Endothelin-1 (ET-1) binding to rat adrenal cells with unlabeled ET-1, and the ET-1 receptor-related peptides sarafotoxin and BQ-123, show that rat adrenal cortex possess, as its bovine counterpart, two different receptors to ET-1 named ET-A and ET-B. Binding of ET-1 to its rat adrenal receptors stimulates i) aldosterone production, in vivo and in vitro ii) calcium influx, which is mediated through voltage dependent- and receptor operated- calcium channels, iii) cholesterol uptake, iv) stimulation of Na+/K+-ATPase and iv) diacylglycerol production. While the last effect is mediated through ET-A receptors the others involve binding of ET-1 to ET-B receptors. Finally, ouabain potentiates the ET-1-mediated stimulation of aldosterone production, suggesting that the effect of the peptidic hormone on Na+/K+-ATPase could act as a negative feedback mechanism. |
| format |
JOUR |
| author |
Pecci, A. Romero, D.G. Lantos, C.P. Cozza, E.N. |
| author_facet |
Pecci, A. Romero, D.G. Lantos, C.P. Cozza, E.N. |
| author_sort |
Pecci, A. |
| title |
Mechanisms of action of endothelin-i in rat adrenal |
| title_short |
Mechanisms of action of endothelin-i in rat adrenal |
| title_full |
Mechanisms of action of endothelin-i in rat adrenal |
| title_fullStr |
Mechanisms of action of endothelin-i in rat adrenal |
| title_full_unstemmed |
Mechanisms of action of endothelin-i in rat adrenal |
| title_sort |
mechanisms of action of endothelin-i in rat adrenal |
| url |
http://hdl.handle.net/20.500.12110/paper_00243205_v63_n15_p1315_Pecci |
| work_keys_str_mv |
AT peccia mechanismsofactionofendotheliniinratadrenal AT romerodg mechanismsofactionofendotheliniinratadrenal AT lantoscp mechanismsofactionofendotheliniinratadrenal AT cozzaen mechanismsofactionofendotheliniinratadrenal |
| _version_ |
1782029221663604736 |