Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions

An ovary autotransplanted into the spleen of a bilaterally ovariectomized rat develops into a luteoma, which grows under constant gonadotropin hyperstimulation. The effect of a long-acting GnRH agonist (GnRH-a), on tumor growth and hormone secretion was investigated. Two experimental models were use...

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Autores principales:	Lux-Lantos, V.A.R., Thyssen, S.M., Chamson, A., Libertun, C.
Formato:	JOUR
Materias:	gonadotropin releasing hormone analog luteoma tumor growth buserelin estradiol estradiol valerate follitropin gonadorelin agonist gonadotropin luteinizing hormone progesterone animal cell animal experiment animal model article autotransplantation cancer cell culture cancer graft cancer inhibition controlled study female hormone blood level hormone release nonhuman ovariectomy ovary tumor rat spleen subcutaneous drug administration Animal Estradiol Female Follicle Stimulating Hormone Gonadorelin Luteinizing Hormone Luteoma Ovarian Neoplasms Progesterone Rats Rats, Sprague-Dawley Support, Non-U.S. Gov't Tumor Cells, Cultured Animalia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00243205_v57_n3_p291_LuxLantos
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00243205_v57_n3_p291_LuxLantos2023-10-03T14:34:38Z Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions Lux-Lantos, V.A.R. Thyssen, S.M. Chamson, A. Libertun, C. gonadotropin releasing hormone analog luteoma tumor growth buserelin estradiol estradiol valerate follitropin gonadorelin agonist gonadotropin luteinizing hormone progesterone animal cell animal experiment animal model article autotransplantation cancer cell culture cancer graft cancer inhibition controlled study female hormone blood level hormone release nonhuman ovariectomy ovary tumor rat spleen subcutaneous drug administration tumor growth Animal Estradiol Female Follicle Stimulating Hormone Gonadorelin Luteinizing Hormone Luteoma Ovarian Neoplasms Progesterone Rats Rats, Sprague-Dawley Support, Non-U.S. Gov't Tumor Cells, Cultured Animalia An ovary autotransplanted into the spleen of a bilaterally ovariectomized rat develops into a luteoma, which grows under constant gonadotropin hyperstimulation. The effect of a long-acting GnRH agonist (GnRH-a), on tumor growth and hormone secretion was investigated. Two experimental models were used: Model 1: GnRH-a (0.33 mg/rat sc) or estradiol valenanate (50 μg/rat sc injected once a week for four weeks) was administered simultaneously with ovary implantation; Model 2: the drugs were administered after 1 month of tumor development. The treatment with estradiol was used as a control of tumor regression. Saline injected ovarian grafted rats and Sham operated animals were used as controls. In Model 1: The GnRH-a significantly inhibited tumor development (Positive tumors: Saline: 100% vs GnRH-a: 43%, p < 0.01). In Model 2: the GnRH-a and estradiol significantly reduced the volume of one month old tumors (52% and 39% of initial volumes respectively, p < 0.01). Gonadotropin secretion was significantly inhibited or its increase blunted by the GnRH-a and by estradiol treatments in both models. Estradiol and progesterone in portal blood, which collects the steroids secreted by the luteoma, were significantly reduced by GnRH-a treatment in both models. On the other hand, in tumor cells cultured "in vitro", the GnRH-a was able to inhibit the LH induced progesterone secretion in a concentration dependent way. These results clearly show that the GnRH-a is effective in inhibiting tumor growth or reducing its volume, when already developed; furthermore, it suppresses tumor steroid hormone production. These actions were exerted at both the hypophyseal and tumor levels. © 1995. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00243205_v57_n3_p291_LuxLantos
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	gonadotropin releasing hormone analog luteoma tumor growth buserelin estradiol estradiol valerate follitropin gonadorelin agonist gonadotropin luteinizing hormone progesterone animal cell animal experiment animal model article autotransplantation cancer cell culture cancer graft cancer inhibition controlled study female hormone blood level hormone release nonhuman ovariectomy ovary tumor rat spleen subcutaneous drug administration tumor growth Animal Estradiol Female Follicle Stimulating Hormone Gonadorelin Luteinizing Hormone Luteoma Ovarian Neoplasms Progesterone Rats Rats, Sprague-Dawley Support, Non-U.S. Gov't Tumor Cells, Cultured Animalia
spellingShingle	gonadotropin releasing hormone analog luteoma tumor growth buserelin estradiol estradiol valerate follitropin gonadorelin agonist gonadotropin luteinizing hormone progesterone animal cell animal experiment animal model article autotransplantation cancer cell culture cancer graft cancer inhibition controlled study female hormone blood level hormone release nonhuman ovariectomy ovary tumor rat spleen subcutaneous drug administration tumor growth Animal Estradiol Female Follicle Stimulating Hormone Gonadorelin Luteinizing Hormone Luteoma Ovarian Neoplasms Progesterone Rats Rats, Sprague-Dawley Support, Non-U.S. Gov't Tumor Cells, Cultured Animalia Lux-Lantos, V.A.R. Thyssen, S.M. Chamson, A. Libertun, C. Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions
topic_facet	gonadotropin releasing hormone analog luteoma tumor growth buserelin estradiol estradiol valerate follitropin gonadorelin agonist gonadotropin luteinizing hormone progesterone animal cell animal experiment animal model article autotransplantation cancer cell culture cancer graft cancer inhibition controlled study female hormone blood level hormone release nonhuman ovariectomy ovary tumor rat spleen subcutaneous drug administration tumor growth Animal Estradiol Female Follicle Stimulating Hormone Gonadorelin Luteinizing Hormone Luteoma Ovarian Neoplasms Progesterone Rats Rats, Sprague-Dawley Support, Non-U.S. Gov't Tumor Cells, Cultured Animalia
description	An ovary autotransplanted into the spleen of a bilaterally ovariectomized rat develops into a luteoma, which grows under constant gonadotropin hyperstimulation. The effect of a long-acting GnRH agonist (GnRH-a), on tumor growth and hormone secretion was investigated. Two experimental models were used: Model 1: GnRH-a (0.33 mg/rat sc) or estradiol valenanate (50 μg/rat sc injected once a week for four weeks) was administered simultaneously with ovary implantation; Model 2: the drugs were administered after 1 month of tumor development. The treatment with estradiol was used as a control of tumor regression. Saline injected ovarian grafted rats and Sham operated animals were used as controls. In Model 1: The GnRH-a significantly inhibited tumor development (Positive tumors: Saline: 100% vs GnRH-a: 43%, p < 0.01). In Model 2: the GnRH-a and estradiol significantly reduced the volume of one month old tumors (52% and 39% of initial volumes respectively, p < 0.01). Gonadotropin secretion was significantly inhibited or its increase blunted by the GnRH-a and by estradiol treatments in both models. Estradiol and progesterone in portal blood, which collects the steroids secreted by the luteoma, were significantly reduced by GnRH-a treatment in both models. On the other hand, in tumor cells cultured "in vitro", the GnRH-a was able to inhibit the LH induced progesterone secretion in a concentration dependent way. These results clearly show that the GnRH-a is effective in inhibiting tumor growth or reducing its volume, when already developed; furthermore, it suppresses tumor steroid hormone production. These actions were exerted at both the hypophyseal and tumor levels. © 1995.
format	JOUR
author	Lux-Lantos, V.A.R. Thyssen, S.M. Chamson, A. Libertun, C.
author_facet	Lux-Lantos, V.A.R. Thyssen, S.M. Chamson, A. Libertun, C.
author_sort	Lux-Lantos, V.A.R.
title	Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions
title_short	Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions
title_full	Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions
title_fullStr	Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions
title_full_unstemmed	Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions
title_sort	effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: direct and indirect actions
url	http://hdl.handle.net/20.500.12110/paper_00243205_v57_n3_p291_LuxLantos
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Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions

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