High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma

Autoimplantation of an ovary, containing fresh corpora lutea, into the spleen of an ovariectomized rat is followed by strong luteinization and size increase of the grafted gonad. Thus, large amounts of luteal tissue for biochemical studies, and their histological controls are available. Furthermore,...

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Autores principales:	Lux, V.A.R., Tesone, M., Larrea, G.A., Libertun, C.
Formato:	JOUR
Materias:	luteinizing hormone receptor progesterone radioisotope animal cell corpus luteum endocrine system female genital system luteinization luteinizing hormone i 125 nonhuman ovary graft priority journal prolactin blood level rat Animal Corpus Luteum Female Kinetics Luteinizing Hormone Ovary Progesterone Prolactin Rats Rats, Inbred Strains Receptors, Cell Surface Receptors, LH Support, Non-U.S. Gov't Transplantation, Autologous
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00243205_v35_n23_p2345_Lux
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00243205_v35_n23_p2345_Lux2023-10-03T14:34:34Z High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma Lux, V.A.R. Tesone, M. Larrea, G.A. Libertun, C. luteinizing hormone receptor progesterone radioisotope animal cell corpus luteum endocrine system female genital system luteinization luteinizing hormone i 125 nonhuman ovary graft priority journal prolactin blood level rat Animal Corpus Luteum Female Kinetics Luteinizing Hormone Ovary Progesterone Prolactin Rats Rats, Inbred Strains Receptors, Cell Surface Receptors, LH Support, Non-U.S. Gov't Transplantation, Autologous Autoimplantation of an ovary, containing fresh corpora lutea, into the spleen of an ovariectomized rat is followed by strong luteinization and size increase of the grafted gonad. Thus, large amounts of luteal tissue for biochemical studies, and their histological controls are available. Furthermore, progesterone secretion can be easily determined in samples collected from the portal vein. Since prolactin has been implicated in the control of luteal tissue, the role of this hormone on hLH binding and progesterone secretion was determined. Different levels of endogenous serum prolactin were achieved by pharmacological treatments with neurotropic agents. Scatchard plots of 125-I hLH binding data derived from luteoma particulate fractions revealed the presence of one type of binding site with high affinity. At the same time as binding increased, prolactinemia augmented, with a high correlation (R:0.99) between prolactinemia and LH binding. Moreover, progesterone secreted by the luteoma increased as LH binding sites augmented (R:0,97). It is concluded that a high correlation between prolactinemia and LH binding, as well as between this last parameter and progesterone output exists in the experimental luteoma. © 1984. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00243205_v35_n23_p2345_Lux
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	luteinizing hormone receptor progesterone radioisotope animal cell corpus luteum endocrine system female genital system luteinization luteinizing hormone i 125 nonhuman ovary graft priority journal prolactin blood level rat Animal Corpus Luteum Female Kinetics Luteinizing Hormone Ovary Progesterone Prolactin Rats Rats, Inbred Strains Receptors, Cell Surface Receptors, LH Support, Non-U.S. Gov't Transplantation, Autologous
spellingShingle	luteinizing hormone receptor progesterone radioisotope animal cell corpus luteum endocrine system female genital system luteinization luteinizing hormone i 125 nonhuman ovary graft priority journal prolactin blood level rat Animal Corpus Luteum Female Kinetics Luteinizing Hormone Ovary Progesterone Prolactin Rats Rats, Inbred Strains Receptors, Cell Surface Receptors, LH Support, Non-U.S. Gov't Transplantation, Autologous Lux, V.A.R. Tesone, M. Larrea, G.A. Libertun, C. High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma
topic_facet	luteinizing hormone receptor progesterone radioisotope animal cell corpus luteum endocrine system female genital system luteinization luteinizing hormone i 125 nonhuman ovary graft priority journal prolactin blood level rat Animal Corpus Luteum Female Kinetics Luteinizing Hormone Ovary Progesterone Prolactin Rats Rats, Inbred Strains Receptors, Cell Surface Receptors, LH Support, Non-U.S. Gov't Transplantation, Autologous
description	Autoimplantation of an ovary, containing fresh corpora lutea, into the spleen of an ovariectomized rat is followed by strong luteinization and size increase of the grafted gonad. Thus, large amounts of luteal tissue for biochemical studies, and their histological controls are available. Furthermore, progesterone secretion can be easily determined in samples collected from the portal vein. Since prolactin has been implicated in the control of luteal tissue, the role of this hormone on hLH binding and progesterone secretion was determined. Different levels of endogenous serum prolactin were achieved by pharmacological treatments with neurotropic agents. Scatchard plots of 125-I hLH binding data derived from luteoma particulate fractions revealed the presence of one type of binding site with high affinity. At the same time as binding increased, prolactinemia augmented, with a high correlation (R:0.99) between prolactinemia and LH binding. Moreover, progesterone secreted by the luteoma increased as LH binding sites augmented (R:0,97). It is concluded that a high correlation between prolactinemia and LH binding, as well as between this last parameter and progesterone output exists in the experimental luteoma. © 1984.
format	JOUR
author	Lux, V.A.R. Tesone, M. Larrea, G.A. Libertun, C.
author_facet	Lux, V.A.R. Tesone, M. Larrea, G.A. Libertun, C.
author_sort	Lux, V.A.R.
title	High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma
title_short	High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma
title_full	High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma
title_fullStr	High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma
title_full_unstemmed	High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma
title_sort	high correlation between prolactinemia, 125-i hlh binding and progesterone secretion by an experimental luteoma
url	http://hdl.handle.net/20.500.12110/paper_00243205_v35_n23_p2345_Lux
work_keys_str_mv	AT luxvar highcorrelationbetweenprolactinemia125ihlhbindingandprogesteronesecretionbyanexperimentalluteoma AT tesonem highcorrelationbetweenprolactinemia125ihlhbindingandprogesteronesecretionbyanexperimentalluteoma AT larreaga highcorrelationbetweenprolactinemia125ihlhbindingandprogesteronesecretionbyanexperimentalluteoma AT libertunc highcorrelationbetweenprolactinemia125ihlhbindingandprogesteronesecretionbyanexperimentalluteoma
_version_	1782030928300736512

High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma

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