Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons

In the isolated rat tail artery preloaded with 3H-noradrenaline, neither acetylsalicyclic acid nor indomethacin modified the tritium release evoked by the Black Widow spider venom gland extract (BWGE), whereas clonidine diminished this effect of the venom. The data suggest that the BWGE process may...

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Autores principales: Fernández Pardal, J., Gimeno, A.L., Barrio, A.
Formato: JOUR
Materias:
rat
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00243205_v26_n21_p1761_FernandezPardal
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spelling todo:paper_00243205_v26_n21_p1761_FernandezPardal2023-10-03T14:34:33Z Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons Fernández Pardal, J. Gimeno, A.L. Barrio, A. acetylsalicylic acid clonidine indometacin noradrenalin prostaglandin radioisotope spider venom animal experiment autonomic nervous system drug release in vitro study noradrenalin h 3 peripheral vascular system rat sympathetic nerve tail artery Animal Arthropod Venoms Aspirin Black Widow Spider Catecholamines Clonidine In Vitro Indomethacin Male Muscle, Smooth, Vascular Neurons Norepinephrine Potassium Prostaglandins Rats Spider Venoms Sympathetic Nervous System In the isolated rat tail artery preloaded with 3H-noradrenaline, neither acetylsalicyclic acid nor indomethacin modified the tritium release evoked by the Black Widow spider venom gland extract (BWGE), whereas clonidine diminished this effect of the venom. The data suggest that the BWGE process may operate in parallel with the prostaglandin mechanism and in series with the NA-mediated feed back pathway. It can not be excluded a prostaglandin interaction on the release process at a step prior to the point at which the venom acts. © 1980. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00243205_v26_n21_p1761_FernandezPardal
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic acetylsalicylic acid
clonidine
indometacin
noradrenalin
prostaglandin
radioisotope
spider venom
animal experiment
autonomic nervous system
drug release
in vitro study
noradrenalin h 3
peripheral vascular system
rat
sympathetic nerve
tail artery
Animal
Arthropod Venoms
Aspirin
Black Widow Spider
Catecholamines
Clonidine
In Vitro
Indomethacin
Male
Muscle, Smooth, Vascular
Neurons
Norepinephrine
Potassium
Prostaglandins
Rats
Spider Venoms
Sympathetic Nervous System
spellingShingle acetylsalicylic acid
clonidine
indometacin
noradrenalin
prostaglandin
radioisotope
spider venom
animal experiment
autonomic nervous system
drug release
in vitro study
noradrenalin h 3
peripheral vascular system
rat
sympathetic nerve
tail artery
Animal
Arthropod Venoms
Aspirin
Black Widow Spider
Catecholamines
Clonidine
In Vitro
Indomethacin
Male
Muscle, Smooth, Vascular
Neurons
Norepinephrine
Potassium
Prostaglandins
Rats
Spider Venoms
Sympathetic Nervous System
Fernández Pardal, J.
Gimeno, A.L.
Barrio, A.
Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons
topic_facet acetylsalicylic acid
clonidine
indometacin
noradrenalin
prostaglandin
radioisotope
spider venom
animal experiment
autonomic nervous system
drug release
in vitro study
noradrenalin h 3
peripheral vascular system
rat
sympathetic nerve
tail artery
Animal
Arthropod Venoms
Aspirin
Black Widow Spider
Catecholamines
Clonidine
In Vitro
Indomethacin
Male
Muscle, Smooth, Vascular
Neurons
Norepinephrine
Potassium
Prostaglandins
Rats
Spider Venoms
Sympathetic Nervous System
description In the isolated rat tail artery preloaded with 3H-noradrenaline, neither acetylsalicyclic acid nor indomethacin modified the tritium release evoked by the Black Widow spider venom gland extract (BWGE), whereas clonidine diminished this effect of the venom. The data suggest that the BWGE process may operate in parallel with the prostaglandin mechanism and in series with the NA-mediated feed back pathway. It can not be excluded a prostaglandin interaction on the release process at a step prior to the point at which the venom acts. © 1980.
format JOUR
author Fernández Pardal, J.
Gimeno, A.L.
Barrio, A.
author_facet Fernández Pardal, J.
Gimeno, A.L.
Barrio, A.
author_sort Fernández Pardal, J.
title Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons
title_short Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons
title_full Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons
title_fullStr Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons
title_full_unstemmed Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons
title_sort inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons
url http://hdl.handle.net/20.500.12110/paper_00243205_v26_n21_p1761_FernandezPardal
work_keys_str_mv AT fernandezpardalj inhibitorsofprostaglandinssynthesisandthereleaseofnoradrenalineevokedbyblackwidowspidervenomglandextractinperipheralcatecholamineneurons
AT gimenoal inhibitorsofprostaglandinssynthesisandthereleaseofnoradrenalineevokedbyblackwidowspidervenomglandextractinperipheralcatecholamineneurons
AT barrioa inhibitorsofprostaglandinssynthesisandthereleaseofnoradrenalineevokedbyblackwidowspidervenomglandextractinperipheralcatecholamineneurons
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