Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition

Oxidative stress is associated with Alzheimer's (DAT) and vascular (VD) dementias, as well as Type II diabetes mellitus (DIAB) and affected by hypoglycemic therapy. The population (n=122; males=60; mean age=72.57±7. 06) consisted of controls (CTR), DAT and VD patients, with (DAT+DIAB, VD+DIAB)...

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Autores principales: Serra, J.A., Marschoff, E.R., Domínguez, R.O., Guareschi, E.M., Famulari, A.L., Pagano, M.A., De Lustig, E.S., Bartolomé, E.L., González, S., D'Abraccio, G., Arata, M., Oudkerk, L., Garau, L., Krinsky, F., Labos, E., Ruiz, C., Frechtel, G., Arana, A., Lovecchio, S.
Formato: JOUR
Materias:
Antioxidant profiles
Non-insulin-dependent Type II diabetes mellitus
Oxidative stress
Probable dementia of the Alzheimer's type
Sulfonylureas
Vascular dementia
alpha glucosidase inhibitor
antidiabetic agent
antioxidant
biguanide
copper zinc superoxide dismutase
glibenclamide
gliclazide
glimepiride
sulfonylurea derivative
thiobarbituric acid reactive substance
adult
aged
Alzheimer disease
analysis of variance
antioxidant activity
article
comorbidity
controlled study
dementia
diagnostic value
female
human
major clinical study
male
multiinfarct dementia
non insulin dependent diabetes mellitus
oxidative stress
priority journal
quantitative analysis
statistical analysis
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0022510X_v218_n1-2_p17_Serra
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_0022510X_v218_n1-2_p17_Serra2023-10-03T14:33:27Z Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition Serra, J.A. Marschoff, E.R. Domínguez, R.O. Guareschi, E.M. Famulari, A.L. Pagano, M.A. De Lustig, E.S. Bartolomé, E.L. González, S. D'Abraccio, G. Arata, M. Oudkerk, L. Garau, L. Krinsky, F. Labos, E. Ruiz, C. Frechtel, G. Arana, A. Lovecchio, S. Antioxidant profiles Non-insulin-dependent Type II diabetes mellitus Oxidative stress Probable dementia of the Alzheimer's type Sulfonylureas Vascular dementia alpha glucosidase inhibitor antidiabetic agent antioxidant biguanide copper zinc superoxide dismutase glibenclamide gliclazide glimepiride sulfonylurea derivative thiobarbituric acid reactive substance adult aged Alzheimer disease analysis of variance antioxidant activity article comorbidity controlled study dementia diagnostic value female human major clinical study male multiinfarct dementia non insulin dependent diabetes mellitus oxidative stress priority journal quantitative analysis statistical analysis Oxidative stress is associated with Alzheimer's (DAT) and vascular (VD) dementias, as well as Type II diabetes mellitus (DIAB) and affected by hypoglycemic therapy. The population (n=122; males=60; mean age=72.57±7. 06) consisted of controls (CTR), DAT and VD patients, with (DAT+DIAB, VD+DIAB) and without concomitant DIAB, resulting in six groups where the antioxidant profile was determined: copper-zinc superoxide dismutase (SOD), thiobarbituric acid reactive substances (TBARS), and total antioxidant capacity (TRAP). The results were analyzed using a two-way ANOVA design and Bonferroni statistic. The ANOVAs yielded significant differences between groups for all components of the profile: SOD, p=0.00000006; TBARS, p=0.0000012; TRAP, p=0.0000003. The significance level for comparisons between groups was set at α=0.05. The comparisons DIAB vs. CTR, DAT+DIAB vs. DAT, and DIAB demented vs. DIAB non-demented resulted significant for all variables. VD+DIAB vs. VD resulted significant for all variables except TRAP. The antioxidant profiles of DIAB and CTR are different. The differences cannot be directly related with what is observed in dementias. The differences in profiles of demented and non-demented are somewhat hidden when demented patients are affected by a concomitant DIAB condition and/or hypoglycemic treatment, thus conditioning the diagnostic value for dementias of the profiles. © 2003 Elsevier B.V. All rights reserved. Fil:Marschoff, E.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0022510X_v218_n1-2_p17_Serra
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Antioxidant profiles
Non-insulin-dependent Type II diabetes mellitus
Oxidative stress
Probable dementia of the Alzheimer's type
Sulfonylureas
Vascular dementia
alpha glucosidase inhibitor
antidiabetic agent
antioxidant
biguanide
copper zinc superoxide dismutase
glibenclamide
gliclazide
glimepiride
sulfonylurea derivative
thiobarbituric acid reactive substance
adult
aged
Alzheimer disease
analysis of variance
antioxidant activity
article
comorbidity
controlled study
dementia
diagnostic value
female
human
major clinical study
male
multiinfarct dementia
non insulin dependent diabetes mellitus
oxidative stress
priority journal
quantitative analysis
statistical analysis
spellingShingle Antioxidant profiles
Non-insulin-dependent Type II diabetes mellitus
Oxidative stress
Probable dementia of the Alzheimer's type
Sulfonylureas
Vascular dementia
alpha glucosidase inhibitor
antidiabetic agent
antioxidant
biguanide
copper zinc superoxide dismutase
glibenclamide
gliclazide
glimepiride
sulfonylurea derivative
thiobarbituric acid reactive substance
adult
aged
Alzheimer disease
analysis of variance
antioxidant activity
article
comorbidity
controlled study
dementia
diagnostic value
female
human
major clinical study
male
multiinfarct dementia
non insulin dependent diabetes mellitus
oxidative stress
priority journal
quantitative analysis
statistical analysis
Serra, J.A.
Marschoff, E.R.
Domínguez, R.O.
Guareschi, E.M.
Famulari, A.L.
Pagano, M.A.
De Lustig, E.S.
Bartolomé, E.L.
González, S.
D'Abraccio, G.
Arata, M.
Oudkerk, L.
Garau, L.
Krinsky, F.
Labos, E.
Ruiz, C.
Frechtel, G.
Arana, A.
Lovecchio, S.
Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition
topic_facet Antioxidant profiles
Non-insulin-dependent Type II diabetes mellitus
Oxidative stress
Probable dementia of the Alzheimer's type
Sulfonylureas
Vascular dementia
alpha glucosidase inhibitor
antidiabetic agent
antioxidant
biguanide
copper zinc superoxide dismutase
glibenclamide
gliclazide
glimepiride
sulfonylurea derivative
thiobarbituric acid reactive substance
adult
aged
Alzheimer disease
analysis of variance
antioxidant activity
article
comorbidity
controlled study
dementia
diagnostic value
female
human
major clinical study
male
multiinfarct dementia
non insulin dependent diabetes mellitus
oxidative stress
priority journal
quantitative analysis
statistical analysis
description Oxidative stress is associated with Alzheimer's (DAT) and vascular (VD) dementias, as well as Type II diabetes mellitus (DIAB) and affected by hypoglycemic therapy. The population (n=122; males=60; mean age=72.57±7. 06) consisted of controls (CTR), DAT and VD patients, with (DAT+DIAB, VD+DIAB) and without concomitant DIAB, resulting in six groups where the antioxidant profile was determined: copper-zinc superoxide dismutase (SOD), thiobarbituric acid reactive substances (TBARS), and total antioxidant capacity (TRAP). The results were analyzed using a two-way ANOVA design and Bonferroni statistic. The ANOVAs yielded significant differences between groups for all components of the profile: SOD, p=0.00000006; TBARS, p=0.0000012; TRAP, p=0.0000003. The significance level for comparisons between groups was set at α=0.05. The comparisons DIAB vs. CTR, DAT+DIAB vs. DAT, and DIAB demented vs. DIAB non-demented resulted significant for all variables. VD+DIAB vs. VD resulted significant for all variables except TRAP. The antioxidant profiles of DIAB and CTR are different. The differences cannot be directly related with what is observed in dementias. The differences in profiles of demented and non-demented are somewhat hidden when demented patients are affected by a concomitant DIAB condition and/or hypoglycemic treatment, thus conditioning the diagnostic value for dementias of the profiles. © 2003 Elsevier B.V. All rights reserved.
format JOUR
author Serra, J.A.
Marschoff, E.R.
Domínguez, R.O.
Guareschi, E.M.
Famulari, A.L.
Pagano, M.A.
De Lustig, E.S.
Bartolomé, E.L.
González, S.
D'Abraccio, G.
Arata, M.
Oudkerk, L.
Garau, L.
Krinsky, F.
Labos, E.
Ruiz, C.
Frechtel, G.
Arana, A.
Lovecchio, S.
author_facet Serra, J.A.
Marschoff, E.R.
Domínguez, R.O.
Guareschi, E.M.
Famulari, A.L.
Pagano, M.A.
De Lustig, E.S.
Bartolomé, E.L.
González, S.
D'Abraccio, G.
Arata, M.
Oudkerk, L.
Garau, L.
Krinsky, F.
Labos, E.
Ruiz, C.
Frechtel, G.
Arana, A.
Lovecchio, S.
author_sort Serra, J.A.
title Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition
title_short Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition
title_full Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition
title_fullStr Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition
title_full_unstemmed Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition
title_sort oxidative stress in alzheimer's and vascular dementias: masking of the antioxidant profiles by a concomitant type ii diabetes mellitus condition
url http://hdl.handle.net/20.500.12110/paper_0022510X_v218_n1-2_p17_Serra
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