Less polar forms and derivatives of 18 hydroxy-corticosterone
The formation of various compounds upon reaction of 18 hydroxycorticosterone with neutral and acid-added alcohols as well as with acidic aqueous solutions is described. The time course of their formation in such media has been studied. Some of these compounds have been isolated and tentatively ident...
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| Autores principales: | , , , |
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00224731_v9_n2_p175_Aragones |
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| Sumario: | The formation of various compounds upon reaction of 18 hydroxycorticosterone with neutral and acid-added alcohols as well as with acidic aqueous solutions is described. The time course of their formation in such media has been studied. Some of these compounds have been isolated and tentatively identified by paper chromatography employing double isotope techniques and by mass spectrometry. The more polar form has a C-20 hemiketalic structure; the single less polar form obtained upon storage in neutral methanol would be the methylketal at C-20 but the less polar fraction having the same mobility in the Chromatographie system employed, obtained upon reaction with acidic aqueous solutions, seems to be formed by two different dehydration products. © 1978. |
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