Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat

In the present work it was observed that the diabetic state alters the hypophyseal response to castration, without the expected increase in the LH serum levels, as found in the control rats. On the other hand, the stimulation of the hypophysis with LHRH resulted in a lower response in the case of th...

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Autores principales: Calvo, J.C., Lino, J., Barañao, S., Tesone, M., Charreau, E.H.
Formato: JOUR
Materias:
gonadorelin
isophane insulin
luteinizing hormone
radioisotope
streptozocin
5alpha androstane 3alpha,17beta diol c 14
androstanolone c 14
animal experiment
animal model
diabetes mellitus
drug efficacy
endocrine system
hypothalamus hypophysis gonad system
nonhuman
rat
testosterone c 14
testosterone h 3
Animal
Castration
Diabetes Mellitus, Experimental
Gonadorelin
Hypothalamo-Hypophyseal System
Luteinizing Hormone
Male
Organ Weight
Rats
Rats, Inbred Strains
Receptors, Androgen
Support, Non-U.S. Gov't
Testis
Testosterone
Testosterone 5-alpha-Reductase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00224731_v20_n3_p769_Calvo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_00224731_v20_n3_p769_Calvo
record_format dspace
spelling todo:paper_00224731_v20_n3_p769_Calvo2023-10-03T14:33:03Z Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat Calvo, J.C. Lino, J. Barañao, S. Tesone, M. Charreau, E.H. gonadorelin isophane insulin luteinizing hormone radioisotope streptozocin 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment animal model diabetes mellitus drug efficacy endocrine system hypothalamus hypophysis gonad system nonhuman rat testosterone c 14 testosterone h 3 Animal Castration Diabetes Mellitus, Experimental Gonadorelin Hypothalamo-Hypophyseal System Luteinizing Hormone Male Organ Weight Rats Rats, Inbred Strains Receptors, Androgen Support, Non-U.S. Gov't Testis Testosterone Testosterone 5-alpha-Reductase In the present work it was observed that the diabetic state alters the hypophyseal response to castration, without the expected increase in the LH serum levels, as found in the control rats. On the other hand, the stimulation of the hypophysis with LHRH resulted in a lower response in the case of the diabetic animal. The results presented herein are in good agreement with the finding of a reduction in the number of androgen binding sites and also with a diminished activity of the 5α-reductase in the hypophysis from diabetic animals. The present results indicate an alteration in the hypophyseal gonadotropin production as well as in the overall process of hypophyseal response in experimental diabetes. © 1984. Fil:Calvo, J.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Barañao, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tesone, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Charreau, E.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00224731_v20_n3_p769_Calvo
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic gonadorelin
isophane insulin
luteinizing hormone
radioisotope
streptozocin
5alpha androstane 3alpha,17beta diol c 14
androstanolone c 14
animal experiment
animal model
diabetes mellitus
drug efficacy
endocrine system
hypothalamus hypophysis gonad system
nonhuman
rat
testosterone c 14
testosterone h 3
Animal
Castration
Diabetes Mellitus, Experimental
Gonadorelin
Hypothalamo-Hypophyseal System
Luteinizing Hormone
Male
Organ Weight
Rats
Rats, Inbred Strains
Receptors, Androgen
Support, Non-U.S. Gov't
Testis
Testosterone
Testosterone 5-alpha-Reductase
spellingShingle gonadorelin
isophane insulin
luteinizing hormone
radioisotope
streptozocin
5alpha androstane 3alpha,17beta diol c 14
androstanolone c 14
animal experiment
animal model
diabetes mellitus
drug efficacy
endocrine system
hypothalamus hypophysis gonad system
nonhuman
rat
testosterone c 14
testosterone h 3
Animal
Castration
Diabetes Mellitus, Experimental
Gonadorelin
Hypothalamo-Hypophyseal System
Luteinizing Hormone
Male
Organ Weight
Rats
Rats, Inbred Strains
Receptors, Androgen
Support, Non-U.S. Gov't
Testis
Testosterone
Testosterone 5-alpha-Reductase
Calvo, J.C.
Lino, J.
Barañao, S.
Tesone, M.
Charreau, E.H.
Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
topic_facet gonadorelin
isophane insulin
luteinizing hormone
radioisotope
streptozocin
5alpha androstane 3alpha,17beta diol c 14
androstanolone c 14
animal experiment
animal model
diabetes mellitus
drug efficacy
endocrine system
hypothalamus hypophysis gonad system
nonhuman
rat
testosterone c 14
testosterone h 3
Animal
Castration
Diabetes Mellitus, Experimental
Gonadorelin
Hypothalamo-Hypophyseal System
Luteinizing Hormone
Male
Organ Weight
Rats
Rats, Inbred Strains
Receptors, Androgen
Support, Non-U.S. Gov't
Testis
Testosterone
Testosterone 5-alpha-Reductase
description In the present work it was observed that the diabetic state alters the hypophyseal response to castration, without the expected increase in the LH serum levels, as found in the control rats. On the other hand, the stimulation of the hypophysis with LHRH resulted in a lower response in the case of the diabetic animal. The results presented herein are in good agreement with the finding of a reduction in the number of androgen binding sites and also with a diminished activity of the 5α-reductase in the hypophysis from diabetic animals. The present results indicate an alteration in the hypophyseal gonadotropin production as well as in the overall process of hypophyseal response in experimental diabetes. © 1984.
format JOUR
author Calvo, J.C.
Lino, J.
Barañao, S.
Tesone, M.
Charreau, E.H.
author_facet Calvo, J.C.
Lino, J.
Barañao, S.
Tesone, M.
Charreau, E.H.
author_sort Calvo, J.C.
title Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
title_short Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
title_full Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
title_fullStr Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
title_full_unstemmed Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
title_sort hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
url http://hdl.handle.net/20.500.12110/paper_00224731_v20_n3_p769_Calvo
work_keys_str_mv AT calvojc hypothalamichypophysealgonadalaxisinthestreptozotocininduceddiabeticmalerat
AT linoj hypothalamichypophysealgonadalaxisinthestreptozotocininduceddiabeticmalerat
AT baranaos hypothalamichypophysealgonadalaxisinthestreptozotocininduceddiabeticmalerat
AT tesonem hypothalamichypophysealgonadalaxisinthestreptozotocininduceddiabeticmalerat
AT charreaueh hypothalamichypophysealgonadalaxisinthestreptozotocininduceddiabeticmalerat
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