Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters
Fifteen illudalane sesquiterpenoids, alcyopterosins A-O (1-15) have been isolated from the subAntarctic soft coral Alcyonium paessleri which was collected at a depth of 200 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Eight of these compounds (2...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00223263_v65_n15_p4482_Palermo |
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todo:paper_00223263_v65_n15_p4482_Palermo2023-10-03T14:31:23Z Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters Palermo, J.A. Brasco, M.F.R. Spagnuolo, C. Seldes, A.M. alcyopterosin A alcyopterosin C alcyopterosin E alcyopterosin H antineoplastic agent illudalane natural product nitric acid derivative sesquiterpenoid unclassified drug antineoplastic activity article cancer cell chemical bond controlled study coral drug cytotoxicity drug isolation drug structure human human cell marine environment nonhuman nuclear Overhauser effect proton nuclear magnetic resonance structure analysis Animals Antarctic Regions Cell Line Cnidaria Esters Humans Magnetic Resonance Spectroscopy Molecular Structure Nitrates Sesquiterpenes Spectroscopy, Fourier Transform Infrared Fifteen illudalane sesquiterpenoids, alcyopterosins A-O (1-15) have been isolated from the subAntarctic soft coral Alcyonium paessleri which was collected at a depth of 200 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Eight of these compounds (2, 3, 5-8, 10, and 13) are the first natural nitrate esters, while the other four (1, 4, 11, and 12) are chlorinated. These compounds are as well the first illudalane sesquiterpenoids to be isolated from the marine environement. Compounds 1, 3, 5, and 8 showeld mild cytotoxicity toward human tumor cell lines. Fil:Palermo, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Spagnuolo, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Seldes, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00223263_v65_n15_p4482_Palermo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
alcyopterosin A alcyopterosin C alcyopterosin E alcyopterosin H antineoplastic agent illudalane natural product nitric acid derivative sesquiterpenoid unclassified drug antineoplastic activity article cancer cell chemical bond controlled study coral drug cytotoxicity drug isolation drug structure human human cell marine environment nonhuman nuclear Overhauser effect proton nuclear magnetic resonance structure analysis Animals Antarctic Regions Cell Line Cnidaria Esters Humans Magnetic Resonance Spectroscopy Molecular Structure Nitrates Sesquiterpenes Spectroscopy, Fourier Transform Infrared |
| spellingShingle |
alcyopterosin A alcyopterosin C alcyopterosin E alcyopterosin H antineoplastic agent illudalane natural product nitric acid derivative sesquiterpenoid unclassified drug antineoplastic activity article cancer cell chemical bond controlled study coral drug cytotoxicity drug isolation drug structure human human cell marine environment nonhuman nuclear Overhauser effect proton nuclear magnetic resonance structure analysis Animals Antarctic Regions Cell Line Cnidaria Esters Humans Magnetic Resonance Spectroscopy Molecular Structure Nitrates Sesquiterpenes Spectroscopy, Fourier Transform Infrared Palermo, J.A. Brasco, M.F.R. Spagnuolo, C. Seldes, A.M. Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters |
| topic_facet |
alcyopterosin A alcyopterosin C alcyopterosin E alcyopterosin H antineoplastic agent illudalane natural product nitric acid derivative sesquiterpenoid unclassified drug antineoplastic activity article cancer cell chemical bond controlled study coral drug cytotoxicity drug isolation drug structure human human cell marine environment nonhuman nuclear Overhauser effect proton nuclear magnetic resonance structure analysis Animals Antarctic Regions Cell Line Cnidaria Esters Humans Magnetic Resonance Spectroscopy Molecular Structure Nitrates Sesquiterpenes Spectroscopy, Fourier Transform Infrared |
| description |
Fifteen illudalane sesquiterpenoids, alcyopterosins A-O (1-15) have been isolated from the subAntarctic soft coral Alcyonium paessleri which was collected at a depth of 200 m near the South Georgia Islands, and their structures were elucidated by spectroscopic techniques. Eight of these compounds (2, 3, 5-8, 10, and 13) are the first natural nitrate esters, while the other four (1, 4, 11, and 12) are chlorinated. These compounds are as well the first illudalane sesquiterpenoids to be isolated from the marine environement. Compounds 1, 3, 5, and 8 showeld mild cytotoxicity toward human tumor cell lines. |
| format |
JOUR |
| author |
Palermo, J.A. Brasco, M.F.R. Spagnuolo, C. Seldes, A.M. |
| author_facet |
Palermo, J.A. Brasco, M.F.R. Spagnuolo, C. Seldes, A.M. |
| author_sort |
Palermo, J.A. |
| title |
Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters |
| title_short |
Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters |
| title_full |
Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters |
| title_fullStr |
Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters |
| title_full_unstemmed |
Illudalane sesquiterpenoids from the soft coral Alcyonium paessleri: The first natural nitrate esters |
| title_sort |
illudalane sesquiterpenoids from the soft coral alcyonium paessleri: the first natural nitrate esters |
| url |
http://hdl.handle.net/20.500.12110/paper_00223263_v65_n15_p4482_Palermo |
| work_keys_str_mv |
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1807316612300144640 |