Prevalence and clinical correlates of pathological affective display in Alzheimer's disease
This study examined the prevalence and correlates of pathological affect in Alzheimer's disease. A consecutive series of 103 patients with Alzheimer's disease were examined with a comprehensive psychiatric assessment that included the pathological laughing and crying scale (PLACS). Forty p...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00223050_v59_n1_p55_Starkstein |
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todo:paper_00223050_v59_n1_p55_Starkstein2023-10-03T14:30:54Z Prevalence and clinical correlates of pathological affective display in Alzheimer's disease Starkstein, S.E. Migliorelli, R. Teson, A. Petracca, G. Chemerinsky, E. Manes, F. Leiguarda, R. Alzheimer's disease Pathological affective display Prevalence affective neurosis aged Alzheimer disease article brain atrophy brain cortex crying depression dysthymia female human major clinical study male mood nonverbal communication priority journal rating scale This study examined the prevalence and correlates of pathological affect in Alzheimer's disease. A consecutive series of 103 patients with Alzheimer's disease were examined with a comprehensive psychiatric assessment that included the pathological laughing and crying scale (PLACS). Forty patients (39%) showed pathological affect: 25% showed crying episodes, and 14% showed laughing or mixed (laughing and crying) episodes. Patients with pathological affect crying showed significantly higher depression scores and a significantly higher frequency of major depression and dysthymia than patients with no pathological affect. Patients with mixed pathological affect showed significantly more subcortical atrophy on CT than patients with pathological affect crying. Forty seven per cent of the patients with pathological affect had no congruent mood disorder, and they showed a significantly longer duration of illness and more severe anosognosia than patients with pathological affect that was congruent with an underlying mood disorder. The study validates the PLACS, and shows the high prevalence of pathological affect in Alzheimer's disease. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00223050_v59_n1_p55_Starkstein |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Alzheimer's disease Pathological affective display Prevalence affective neurosis aged Alzheimer disease article brain atrophy brain cortex crying depression dysthymia female human major clinical study male mood nonverbal communication priority journal rating scale |
| spellingShingle |
Alzheimer's disease Pathological affective display Prevalence affective neurosis aged Alzheimer disease article brain atrophy brain cortex crying depression dysthymia female human major clinical study male mood nonverbal communication priority journal rating scale Starkstein, S.E. Migliorelli, R. Teson, A. Petracca, G. Chemerinsky, E. Manes, F. Leiguarda, R. Prevalence and clinical correlates of pathological affective display in Alzheimer's disease |
| topic_facet |
Alzheimer's disease Pathological affective display Prevalence affective neurosis aged Alzheimer disease article brain atrophy brain cortex crying depression dysthymia female human major clinical study male mood nonverbal communication priority journal rating scale |
| description |
This study examined the prevalence and correlates of pathological affect in Alzheimer's disease. A consecutive series of 103 patients with Alzheimer's disease were examined with a comprehensive psychiatric assessment that included the pathological laughing and crying scale (PLACS). Forty patients (39%) showed pathological affect: 25% showed crying episodes, and 14% showed laughing or mixed (laughing and crying) episodes. Patients with pathological affect crying showed significantly higher depression scores and a significantly higher frequency of major depression and dysthymia than patients with no pathological affect. Patients with mixed pathological affect showed significantly more subcortical atrophy on CT than patients with pathological affect crying. Forty seven per cent of the patients with pathological affect had no congruent mood disorder, and they showed a significantly longer duration of illness and more severe anosognosia than patients with pathological affect that was congruent with an underlying mood disorder. The study validates the PLACS, and shows the high prevalence of pathological affect in Alzheimer's disease. |
| format |
JOUR |
| author |
Starkstein, S.E. Migliorelli, R. Teson, A. Petracca, G. Chemerinsky, E. Manes, F. Leiguarda, R. |
| author_facet |
Starkstein, S.E. Migliorelli, R. Teson, A. Petracca, G. Chemerinsky, E. Manes, F. Leiguarda, R. |
| author_sort |
Starkstein, S.E. |
| title |
Prevalence and clinical correlates of pathological affective display in Alzheimer's disease |
| title_short |
Prevalence and clinical correlates of pathological affective display in Alzheimer's disease |
| title_full |
Prevalence and clinical correlates of pathological affective display in Alzheimer's disease |
| title_fullStr |
Prevalence and clinical correlates of pathological affective display in Alzheimer's disease |
| title_full_unstemmed |
Prevalence and clinical correlates of pathological affective display in Alzheimer's disease |
| title_sort |
prevalence and clinical correlates of pathological affective display in alzheimer's disease |
| url |
http://hdl.handle.net/20.500.12110/paper_00223050_v59_n1_p55_Starkstein |
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