N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms

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Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase path...

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Autores principales: Baidanoff, F.M., Plano, S.A., Doctorovich, F., Suárez, S.A., Golombek, D.A., Chiesa, J.J.
Formato: INPR
Lenguaje:English
Materias:
Circadian
Jet lag
N-nitrosomelatonin
Nitric oxide
Suprachiasmatic nucleus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00223042_v_n_p_Baidanoff
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_00223042_v_n_p_Baidanoff2023-10-03T14:30:53Z N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms Baidanoff, F.M. Plano, S.A. Doctorovich, F. Suárez, S.A. Golombek, D.A. Chiesa, J.J. Circadian Jet lag N-nitrosomelatonin Nitric oxide Suprachiasmatic nucleus Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a twofold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of FBJ murine osteosarcoma viral oncogene and period1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-h delay). Here, we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances. © 2013 International Society for Neurochemistry. Fil:Doctorovich, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Suárez, S.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Golombek, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Chiesa, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. INPR English info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00223042_v_n_p_Baidanoff
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
language English
orig_language_str_mv English
topic Circadian
Jet lag
N-nitrosomelatonin
Nitric oxide
Suprachiasmatic nucleus
spellingShingle Circadian
Jet lag
N-nitrosomelatonin
Nitric oxide
Suprachiasmatic nucleus
Baidanoff, F.M.
Plano, S.A.
Doctorovich, F.
Suárez, S.A.
Golombek, D.A.
Chiesa, J.J.
N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
topic_facet Circadian
Jet lag
N-nitrosomelatonin
Nitric oxide
Suprachiasmatic nucleus
description Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a twofold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of FBJ murine osteosarcoma viral oncogene and period1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-h delay). Here, we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances. © 2013 International Society for Neurochemistry.
format INPR
author Baidanoff, F.M.
Plano, S.A.
Doctorovich, F.
Suárez, S.A.
Golombek, D.A.
Chiesa, J.J.
author_facet Baidanoff, F.M.
Plano, S.A.
Doctorovich, F.
Suárez, S.A.
Golombek, D.A.
Chiesa, J.J.
author_sort Baidanoff, F.M.
title N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
title_short N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
title_full N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
title_fullStr N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
title_full_unstemmed N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
title_sort n-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
url http://hdl.handle.net/20.500.12110/paper_00223042_v_n_p_Baidanoff
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