Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies
A new charge transfer (CT) complex [(DAPH) + (DNB) - ] consisting of 2,6-diaminopyridine (DAP) as donor and 3,5-dinitrobenzoic acid (DNB-H) as acceptor, was synthesized and characterized by FTIR, 1 H and 13 C NMR, ESI mass spectroscopic and X-ray crystallographic techniques. The hydrogen bonding (N...
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todo:paper_00222860_v1035_n_p38_Khan2023-10-03T14:30:29Z Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies Khan, I.M. Ahmad, A. Kumar, S. 2,6-Diaminopyridine 3,5-Dinitrobenzoic acid 13 C NMR 1 H NMR Charge transfer DNA-binding 2,6-Diaminopyridine Anti-bacterial activity Anti-fungal properties Antimicrobial study Aspergillus niger Bacillus Subtilis Calf thymus DNA Candida albicans Charge transfer complex CT complex DNA-binding Esi mass FTIR Gram-negative bacteria Gram-positive bacterium H-bonding interaction Penicillium sp Pseudomonas aeruginosa Spectroscopic characterization Staphylococcus aureus Structural investigation Aspergillus Charge transfer Escherichia coli Hydrogen bonds Nuclear magnetic resonance spectroscopy X ray crystallography Bacteria Aspergillus niger Bacillus subtilis Candida albicans Escherichia coli Negibacteria Penicillium Penicillium sp. Posibacteria Pseudomonas aeruginosa Staphylococcus aureus A new charge transfer (CT) complex [(DAPH) + (DNB) - ] consisting of 2,6-diaminopyridine (DAP) as donor and 3,5-dinitrobenzoic acid (DNB-H) as acceptor, was synthesized and characterized by FTIR, 1 H and 13 C NMR, ESI mass spectroscopic and X-ray crystallographic techniques. The hydrogen bonding (N + -H⋯O - ) plays an important role to consolidate the cation and anion together. CT complex shows a considerable interaction with Calf thymus DNA. The CT complex was also tested for its antibacterial activity against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and two Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa strains by using Tetracycline as standard, and antifungal property against Aspergillus niger, Candida albicans, and Penicillium sp. by using Nystatin as standard. The results were compared with standard drugs and significant conclusions were obtained. A polymeric net work through H-bonding interactions between neighboring moieties was observed. This has been attributed to the formation of 1:1 type CT complex. © 2012 Elsevier B.V. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00222860_v1035_n_p38_Khan |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
2,6-Diaminopyridine 3,5-Dinitrobenzoic acid 13 C NMR 1 H NMR Charge transfer DNA-binding 2,6-Diaminopyridine Anti-bacterial activity Anti-fungal properties Antimicrobial study Aspergillus niger Bacillus Subtilis Calf thymus DNA Candida albicans Charge transfer complex CT complex DNA-binding Esi mass FTIR Gram-negative bacteria Gram-positive bacterium H-bonding interaction Penicillium sp Pseudomonas aeruginosa Spectroscopic characterization Staphylococcus aureus Structural investigation Aspergillus Charge transfer Escherichia coli Hydrogen bonds Nuclear magnetic resonance spectroscopy X ray crystallography Bacteria Aspergillus niger Bacillus subtilis Candida albicans Escherichia coli Negibacteria Penicillium Penicillium sp. Posibacteria Pseudomonas aeruginosa Staphylococcus aureus |
| spellingShingle |
2,6-Diaminopyridine 3,5-Dinitrobenzoic acid 13 C NMR 1 H NMR Charge transfer DNA-binding 2,6-Diaminopyridine Anti-bacterial activity Anti-fungal properties Antimicrobial study Aspergillus niger Bacillus Subtilis Calf thymus DNA Candida albicans Charge transfer complex CT complex DNA-binding Esi mass FTIR Gram-negative bacteria Gram-positive bacterium H-bonding interaction Penicillium sp Pseudomonas aeruginosa Spectroscopic characterization Staphylococcus aureus Structural investigation Aspergillus Charge transfer Escherichia coli Hydrogen bonds Nuclear magnetic resonance spectroscopy X ray crystallography Bacteria Aspergillus niger Bacillus subtilis Candida albicans Escherichia coli Negibacteria Penicillium Penicillium sp. Posibacteria Pseudomonas aeruginosa Staphylococcus aureus Khan, I.M. Ahmad, A. Kumar, S. Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies |
| topic_facet |
2,6-Diaminopyridine 3,5-Dinitrobenzoic acid 13 C NMR 1 H NMR Charge transfer DNA-binding 2,6-Diaminopyridine Anti-bacterial activity Anti-fungal properties Antimicrobial study Aspergillus niger Bacillus Subtilis Calf thymus DNA Candida albicans Charge transfer complex CT complex DNA-binding Esi mass FTIR Gram-negative bacteria Gram-positive bacterium H-bonding interaction Penicillium sp Pseudomonas aeruginosa Spectroscopic characterization Staphylococcus aureus Structural investigation Aspergillus Charge transfer Escherichia coli Hydrogen bonds Nuclear magnetic resonance spectroscopy X ray crystallography Bacteria Aspergillus niger Bacillus subtilis Candida albicans Escherichia coli Negibacteria Penicillium Penicillium sp. Posibacteria Pseudomonas aeruginosa Staphylococcus aureus |
| description |
A new charge transfer (CT) complex [(DAPH) + (DNB) - ] consisting of 2,6-diaminopyridine (DAP) as donor and 3,5-dinitrobenzoic acid (DNB-H) as acceptor, was synthesized and characterized by FTIR, 1 H and 13 C NMR, ESI mass spectroscopic and X-ray crystallographic techniques. The hydrogen bonding (N + -H⋯O - ) plays an important role to consolidate the cation and anion together. CT complex shows a considerable interaction with Calf thymus DNA. The CT complex was also tested for its antibacterial activity against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and two Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa strains by using Tetracycline as standard, and antifungal property against Aspergillus niger, Candida albicans, and Penicillium sp. by using Nystatin as standard. The results were compared with standard drugs and significant conclusions were obtained. A polymeric net work through H-bonding interactions between neighboring moieties was observed. This has been attributed to the formation of 1:1 type CT complex. © 2012 Elsevier B.V. All rights reserved. |
| format |
JOUR |
| author |
Khan, I.M. Ahmad, A. Kumar, S. |
| author_facet |
Khan, I.M. Ahmad, A. Kumar, S. |
| author_sort |
Khan, I.M. |
| title |
Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies |
| title_short |
Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies |
| title_full |
Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies |
| title_fullStr |
Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies |
| title_full_unstemmed |
Synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: DNA binding and antimicrobial studies |
| title_sort |
synthesis, spectroscopic characterization and structural investigations of a new charge transfer complex of 2,6-diaminopyridine with 3,5-dinitrobenzoic acid: dna binding and antimicrobial studies |
| url |
http://hdl.handle.net/20.500.12110/paper_00222860_v1035_n_p38_Khan |
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AT khanim synthesisspectroscopiccharacterizationandstructuralinvestigationsofanewchargetransfercomplexof26diaminopyridinewith35dinitrobenzoicaciddnabindingandantimicrobialstudies AT ahmada synthesisspectroscopiccharacterizationandstructuralinvestigationsofanewchargetransfercomplexof26diaminopyridinewith35dinitrobenzoicaciddnabindingandantimicrobialstudies AT kumars synthesisspectroscopiccharacterizationandstructuralinvestigationsofanewchargetransfercomplexof26diaminopyridinewith35dinitrobenzoicaciddnabindingandantimicrobialstudies |
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