Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways
Along with the discovery of tumor-driven inflammatory pathways, there has been a considerable progress over the past 10 years in understanding the mechanisms leading to cancer immunosurveillance and immunoediting. Several regulatory pathways, typically involved in immune cell homeostasis, are co-opt...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00222836_v428_n16_p3266_Rabinovich |
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todo:paper_00222836_v428_n16_p3266_Rabinovich2023-10-03T14:30:23Z Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways Rabinovich, G.A. Conejo-García, J.R. Cancer Galectins Glycans Immunotherapy Tumor Immunity activated leukocyte cell adhesion molecule B lymphocyte receptor CD45 antigen CD7 antigen cytokine receptor cytotoxic T lymphocyte antigen 4 ecalectin galectin galectin 1 galectin 10 galectin 3 galectin 8 glycan glycolipid glycoprotein interleukin 10 interleukin 15 interleukin 2 interleukin 4 lag 3 protein leukosialin n acetylglucosaminyltransferase natural killer cell receptor NKG2D programmed death 1 ligand 1 protein T lymphocyte receptor tim 3 protein transforming growth factor beta unclassified drug unindexed drug vasculotropin receptor 2 galectin ligand angiogenesis antigen presenting cell apoptosis bone marrow cell breast cancer cancer patient carbohydrate synthesis CD8+ T lymphocyte cell adhesion cell differentiation cell migration chronic lymphatic leukemia classical Hodgkin lymphoma commensal cross linking cutaneous T cell lymphoma cytokine production cytokine release cytotoxic T lymphocyte endothelium cell epithelial mesenchymal transition fibroblast glycosylation human immune evasion immunocompetent cell immunosuppressive treatment immunosurveillance inflammation inflammatory cell inflammatory infiltrate Kaposi sarcoma lung adenocarcinoma lymphoid cell malignant neoplastic disease melanoma mycosis fungoides natural killer cell non small cell lung cancer nonhuman ovary cancer pancreas adenocarcinoma priority journal prostate carcinoma protein protein interaction regulatory T lymphocyte Review Sezary syndrome T cell lymphoma Th1 cell Th17 cell tumor growth tumor immunity tumor microenvironment upregulation animal immunology neoplasm signal transduction Animals Galectins Glycosylation Humans Ligands Neoplasms Signal Transduction Tumor Microenvironment Along with the discovery of tumor-driven inflammatory pathways, there has been a considerable progress over the past 10 years in understanding the mechanisms leading to cancer immunosurveillance and immunoediting. Several regulatory pathways, typically involved in immune cell homeostasis, are co-opted by cancer cells to thwart the development of effective antitumor responses. These regulatory circuits include the engagement of inhibitory checkpoint pathways (CTLA-4, PD-1/PD-L1, LAG-3 and TIM-3), secretion of immunosuppressive cytokines (TGF-β, IL-10), and expansion and/or recruitment of myeloid or lymphoid regulatory cell populations. Elucidation of these pathways has inspired the design and implementation of novel immunotherapeutic modalities, which have already generated clinical benefits in an important number of cancer patients. Galectins, a family of glycan-binding proteins widely expressed in the tumor microenvironment (TME), have emerged as key players in immune evasion programs that differentially control the fate of effector and regulatory lymphoid and myeloid cell populations. How do galectins translate glycan-containing information into cellular programs that control immune regulatory cancer networks? Here, we uncover the selective roles of individual members of the galectin family in cancer-promoting inflammation, immunosuppression, and angiogenesis. Moreover, we highlight the relevance of corresponding glycosylated ligands and counter-receptors and the emerging function of these lectins as biological liaisons connecting commensal microbiota, systemic inflammation, and distal tumor growth. Understanding the molecular and cellular components of galectin-driven regulatory circuits, the implications of different glycosylation pathways in their functions and their clinical relevance in human cancer might lead to the development of new therapeutic approaches in a broad range of tumor types. © 2016 Elsevier Ltd JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00222836_v428_n16_p3266_Rabinovich |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cancer Galectins Glycans Immunotherapy Tumor Immunity activated leukocyte cell adhesion molecule B lymphocyte receptor CD45 antigen CD7 antigen cytokine receptor cytotoxic T lymphocyte antigen 4 ecalectin galectin galectin 1 galectin 10 galectin 3 galectin 8 glycan glycolipid glycoprotein interleukin 10 interleukin 15 interleukin 2 interleukin 4 lag 3 protein leukosialin n acetylglucosaminyltransferase natural killer cell receptor NKG2D programmed death 1 ligand 1 protein T lymphocyte receptor tim 3 protein transforming growth factor beta unclassified drug unindexed drug vasculotropin receptor 2 galectin ligand angiogenesis antigen presenting cell apoptosis bone marrow cell breast cancer cancer patient carbohydrate synthesis CD8+ T lymphocyte cell adhesion cell differentiation cell migration chronic lymphatic leukemia classical Hodgkin lymphoma commensal cross linking cutaneous T cell lymphoma cytokine production cytokine release cytotoxic T lymphocyte endothelium cell epithelial mesenchymal transition fibroblast glycosylation human immune evasion immunocompetent cell immunosuppressive treatment immunosurveillance inflammation inflammatory cell inflammatory infiltrate Kaposi sarcoma lung adenocarcinoma lymphoid cell malignant neoplastic disease melanoma mycosis fungoides natural killer cell non small cell lung cancer nonhuman ovary cancer pancreas adenocarcinoma priority journal prostate carcinoma protein protein interaction regulatory T lymphocyte Review Sezary syndrome T cell lymphoma Th1 cell Th17 cell tumor growth tumor immunity tumor microenvironment upregulation animal immunology neoplasm signal transduction Animals Galectins Glycosylation Humans Ligands Neoplasms Signal Transduction Tumor Microenvironment |
| spellingShingle |
Cancer Galectins Glycans Immunotherapy Tumor Immunity activated leukocyte cell adhesion molecule B lymphocyte receptor CD45 antigen CD7 antigen cytokine receptor cytotoxic T lymphocyte antigen 4 ecalectin galectin galectin 1 galectin 10 galectin 3 galectin 8 glycan glycolipid glycoprotein interleukin 10 interleukin 15 interleukin 2 interleukin 4 lag 3 protein leukosialin n acetylglucosaminyltransferase natural killer cell receptor NKG2D programmed death 1 ligand 1 protein T lymphocyte receptor tim 3 protein transforming growth factor beta unclassified drug unindexed drug vasculotropin receptor 2 galectin ligand angiogenesis antigen presenting cell apoptosis bone marrow cell breast cancer cancer patient carbohydrate synthesis CD8+ T lymphocyte cell adhesion cell differentiation cell migration chronic lymphatic leukemia classical Hodgkin lymphoma commensal cross linking cutaneous T cell lymphoma cytokine production cytokine release cytotoxic T lymphocyte endothelium cell epithelial mesenchymal transition fibroblast glycosylation human immune evasion immunocompetent cell immunosuppressive treatment immunosurveillance inflammation inflammatory cell inflammatory infiltrate Kaposi sarcoma lung adenocarcinoma lymphoid cell malignant neoplastic disease melanoma mycosis fungoides natural killer cell non small cell lung cancer nonhuman ovary cancer pancreas adenocarcinoma priority journal prostate carcinoma protein protein interaction regulatory T lymphocyte Review Sezary syndrome T cell lymphoma Th1 cell Th17 cell tumor growth tumor immunity tumor microenvironment upregulation animal immunology neoplasm signal transduction Animals Galectins Glycosylation Humans Ligands Neoplasms Signal Transduction Tumor Microenvironment Rabinovich, G.A. Conejo-García, J.R. Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways |
| topic_facet |
Cancer Galectins Glycans Immunotherapy Tumor Immunity activated leukocyte cell adhesion molecule B lymphocyte receptor CD45 antigen CD7 antigen cytokine receptor cytotoxic T lymphocyte antigen 4 ecalectin galectin galectin 1 galectin 10 galectin 3 galectin 8 glycan glycolipid glycoprotein interleukin 10 interleukin 15 interleukin 2 interleukin 4 lag 3 protein leukosialin n acetylglucosaminyltransferase natural killer cell receptor NKG2D programmed death 1 ligand 1 protein T lymphocyte receptor tim 3 protein transforming growth factor beta unclassified drug unindexed drug vasculotropin receptor 2 galectin ligand angiogenesis antigen presenting cell apoptosis bone marrow cell breast cancer cancer patient carbohydrate synthesis CD8+ T lymphocyte cell adhesion cell differentiation cell migration chronic lymphatic leukemia classical Hodgkin lymphoma commensal cross linking cutaneous T cell lymphoma cytokine production cytokine release cytotoxic T lymphocyte endothelium cell epithelial mesenchymal transition fibroblast glycosylation human immune evasion immunocompetent cell immunosuppressive treatment immunosurveillance inflammation inflammatory cell inflammatory infiltrate Kaposi sarcoma lung adenocarcinoma lymphoid cell malignant neoplastic disease melanoma mycosis fungoides natural killer cell non small cell lung cancer nonhuman ovary cancer pancreas adenocarcinoma priority journal prostate carcinoma protein protein interaction regulatory T lymphocyte Review Sezary syndrome T cell lymphoma Th1 cell Th17 cell tumor growth tumor immunity tumor microenvironment upregulation animal immunology neoplasm signal transduction Animals Galectins Glycosylation Humans Ligands Neoplasms Signal Transduction Tumor Microenvironment |
| description |
Along with the discovery of tumor-driven inflammatory pathways, there has been a considerable progress over the past 10 years in understanding the mechanisms leading to cancer immunosurveillance and immunoediting. Several regulatory pathways, typically involved in immune cell homeostasis, are co-opted by cancer cells to thwart the development of effective antitumor responses. These regulatory circuits include the engagement of inhibitory checkpoint pathways (CTLA-4, PD-1/PD-L1, LAG-3 and TIM-3), secretion of immunosuppressive cytokines (TGF-β, IL-10), and expansion and/or recruitment of myeloid or lymphoid regulatory cell populations. Elucidation of these pathways has inspired the design and implementation of novel immunotherapeutic modalities, which have already generated clinical benefits in an important number of cancer patients. Galectins, a family of glycan-binding proteins widely expressed in the tumor microenvironment (TME), have emerged as key players in immune evasion programs that differentially control the fate of effector and regulatory lymphoid and myeloid cell populations. How do galectins translate glycan-containing information into cellular programs that control immune regulatory cancer networks? Here, we uncover the selective roles of individual members of the galectin family in cancer-promoting inflammation, immunosuppression, and angiogenesis. Moreover, we highlight the relevance of corresponding glycosylated ligands and counter-receptors and the emerging function of these lectins as biological liaisons connecting commensal microbiota, systemic inflammation, and distal tumor growth. Understanding the molecular and cellular components of galectin-driven regulatory circuits, the implications of different glycosylation pathways in their functions and their clinical relevance in human cancer might lead to the development of new therapeutic approaches in a broad range of tumor types. © 2016 Elsevier Ltd |
| format |
JOUR |
| author |
Rabinovich, G.A. Conejo-García, J.R. |
| author_facet |
Rabinovich, G.A. Conejo-García, J.R. |
| author_sort |
Rabinovich, G.A. |
| title |
Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways |
| title_short |
Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways |
| title_full |
Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways |
| title_fullStr |
Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways |
| title_full_unstemmed |
Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways |
| title_sort |
shaping the immune landscape in cancer by galectin-driven regulatory pathways |
| url |
http://hdl.handle.net/20.500.12110/paper_00222836_v428_n16_p3266_Rabinovich |
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AT rabinovichga shapingtheimmunelandscapeincancerbygalectindrivenregulatorypathways AT conejogarciajr shapingtheimmunelandscapeincancerbygalectindrivenregulatorypathways |
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