Evolution of linear motifs within the papillomavirus E7 oncoprotein

Many protein functions can be traced to linear sequence motifs of less than five residues, which are often found within intrinsically disordered domains. In spite of their prevalence, their role in protein evolution is only beginning to be understood. The study of papillomaviruses has provided many...

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Autores principales:	Chemes, L.B., Glavina, J., Faivovich, J., De Prat-Gay, G., Sánchez, I.E.
Formato:	JOUR
Materias:	adaptive evolution convergent evolution intrinsic disorder sequence motif virus homodimer protein E7 amino terminal sequence article carboxy terminal sequence enzyme phosphorylation gene mutation genetic variability molecular evolution nonhuman Papilloma virus papillomavirus infection PDZ domain phenotype phylogeny priority journal protein domain protein function protein motif viral tropism virus cell interaction virus virulence Amino Acid Motifs Amino Acid Sequence Evolution, Molecular Molecular Sequence Data Papillomaviridae Papillomavirus E7 Proteins Protein Structure, Tertiary Sequence Alignment
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00222836_v422_n3_p336_Chemes
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00222836_v422_n3_p336_Chemes
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spelling	todo:paper_00222836_v422_n3_p336_Chemes2023-10-03T14:30:23Z Evolution of linear motifs within the papillomavirus E7 oncoprotein Chemes, L.B. Glavina, J. Faivovich, J. De Prat-Gay, G. Sánchez, I.E. adaptive evolution convergent evolution intrinsic disorder sequence motif virus homodimer protein E7 amino terminal sequence article carboxy terminal sequence convergent evolution enzyme phosphorylation gene mutation genetic variability molecular evolution nonhuman Papilloma virus papillomavirus infection PDZ domain phenotype phylogeny priority journal protein domain protein function protein motif viral tropism virus cell interaction virus virulence Amino Acid Motifs Amino Acid Sequence Evolution, Molecular Molecular Sequence Data Papillomaviridae Papillomavirus E7 Proteins Protein Structure, Tertiary Sequence Alignment Papillomaviridae Many protein functions can be traced to linear sequence motifs of less than five residues, which are often found within intrinsically disordered domains. In spite of their prevalence, their role in protein evolution is only beginning to be understood. The study of papillomaviruses has provided many insights on the evolution of protein structure and function. We have chosen the papillomavirus E7 oncoprotein as a model system for the evolution of functional linear motifs. The multiple functions of E7 proteins from paradigmatic papillomavirus types can be explained to a large extent in terms of five linear motifs within the intrinsically disordered N-terminal domain and two linear motifs within the globular homodimeric C-terminal domain. We examined the motif inventory of E7 proteins from over 200 known papillomavirus types and found that the motifs reported for paradigmatic papillomavirus types are absent from many uncharacterized E7 proteins. Several motif pairs occur more often than expected, suggesting that linear motifs may evolve and function in a cooperative manner. The E7 linear motifs have appeared or disappeared multiple times during papillomavirus evolution, confirming the evolutionary plasticity of short functional sequences. Four of the motifs appeared several times during papillomavirus evolution, providing direct evidence for convergent evolution. Interestingly, the evolution pattern of a motif is independent of its location in a globular or disordered domain. The correlation between the presence of some motifs and virus host specificity and tissue tropism suggests that linear motifs play a role in the adaptive evolution of papillomaviruses. © 2012 Elsevier Ltd. All rights reserved. Fil:Chemes, L.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Faivovich, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:De Prat-Gay, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00222836_v422_n3_p336_Chemes
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	adaptive evolution convergent evolution intrinsic disorder sequence motif virus homodimer protein E7 amino terminal sequence article carboxy terminal sequence convergent evolution enzyme phosphorylation gene mutation genetic variability molecular evolution nonhuman Papilloma virus papillomavirus infection PDZ domain phenotype phylogeny priority journal protein domain protein function protein motif viral tropism virus cell interaction virus virulence Amino Acid Motifs Amino Acid Sequence Evolution, Molecular Molecular Sequence Data Papillomaviridae Papillomavirus E7 Proteins Protein Structure, Tertiary Sequence Alignment Papillomaviridae
spellingShingle	adaptive evolution convergent evolution intrinsic disorder sequence motif virus homodimer protein E7 amino terminal sequence article carboxy terminal sequence convergent evolution enzyme phosphorylation gene mutation genetic variability molecular evolution nonhuman Papilloma virus papillomavirus infection PDZ domain phenotype phylogeny priority journal protein domain protein function protein motif viral tropism virus cell interaction virus virulence Amino Acid Motifs Amino Acid Sequence Evolution, Molecular Molecular Sequence Data Papillomaviridae Papillomavirus E7 Proteins Protein Structure, Tertiary Sequence Alignment Papillomaviridae Chemes, L.B. Glavina, J. Faivovich, J. De Prat-Gay, G. Sánchez, I.E. Evolution of linear motifs within the papillomavirus E7 oncoprotein
topic_facet	adaptive evolution convergent evolution intrinsic disorder sequence motif virus homodimer protein E7 amino terminal sequence article carboxy terminal sequence convergent evolution enzyme phosphorylation gene mutation genetic variability molecular evolution nonhuman Papilloma virus papillomavirus infection PDZ domain phenotype phylogeny priority journal protein domain protein function protein motif viral tropism virus cell interaction virus virulence Amino Acid Motifs Amino Acid Sequence Evolution, Molecular Molecular Sequence Data Papillomaviridae Papillomavirus E7 Proteins Protein Structure, Tertiary Sequence Alignment Papillomaviridae
description	Many protein functions can be traced to linear sequence motifs of less than five residues, which are often found within intrinsically disordered domains. In spite of their prevalence, their role in protein evolution is only beginning to be understood. The study of papillomaviruses has provided many insights on the evolution of protein structure and function. We have chosen the papillomavirus E7 oncoprotein as a model system for the evolution of functional linear motifs. The multiple functions of E7 proteins from paradigmatic papillomavirus types can be explained to a large extent in terms of five linear motifs within the intrinsically disordered N-terminal domain and two linear motifs within the globular homodimeric C-terminal domain. We examined the motif inventory of E7 proteins from over 200 known papillomavirus types and found that the motifs reported for paradigmatic papillomavirus types are absent from many uncharacterized E7 proteins. Several motif pairs occur more often than expected, suggesting that linear motifs may evolve and function in a cooperative manner. The E7 linear motifs have appeared or disappeared multiple times during papillomavirus evolution, confirming the evolutionary plasticity of short functional sequences. Four of the motifs appeared several times during papillomavirus evolution, providing direct evidence for convergent evolution. Interestingly, the evolution pattern of a motif is independent of its location in a globular or disordered domain. The correlation between the presence of some motifs and virus host specificity and tissue tropism suggests that linear motifs play a role in the adaptive evolution of papillomaviruses. © 2012 Elsevier Ltd. All rights reserved.
format	JOUR
author	Chemes, L.B. Glavina, J. Faivovich, J. De Prat-Gay, G. Sánchez, I.E.
author_facet	Chemes, L.B. Glavina, J. Faivovich, J. De Prat-Gay, G. Sánchez, I.E.
author_sort	Chemes, L.B.
title	Evolution of linear motifs within the papillomavirus E7 oncoprotein
title_short	Evolution of linear motifs within the papillomavirus E7 oncoprotein
title_full	Evolution of linear motifs within the papillomavirus E7 oncoprotein
title_fullStr	Evolution of linear motifs within the papillomavirus E7 oncoprotein
title_full_unstemmed	Evolution of linear motifs within the papillomavirus E7 oncoprotein
title_sort	evolution of linear motifs within the papillomavirus e7 oncoprotein
url	http://hdl.handle.net/20.500.12110/paper_00222836_v422_n3_p336_Chemes
work_keys_str_mv	AT chemeslb evolutionoflinearmotifswithinthepapillomaviruse7oncoprotein AT glavinaj evolutionoflinearmotifswithinthepapillomaviruse7oncoprotein AT faivovichj evolutionoflinearmotifswithinthepapillomaviruse7oncoprotein AT depratgayg evolutionoflinearmotifswithinthepapillomaviruse7oncoprotein AT sanchezie evolutionoflinearmotifswithinthepapillomaviruse7oncoprotein
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Evolution of linear motifs within the papillomavirus E7 oncoprotein

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