IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB

Interferon-γ (IFN-γ) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-γ transcription. We determined whether the transmembrane receptor signaling lymphocyte activation molecule (SLAM) and interleukin...

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Autores principales:	Pasquinelli, V., Townsend, J.C., Jurado, J.O., Alvarez, I.B., Quiroga, M.F., Barnes, P.F., Samten, B., García, V.E.
Formato:	JOUR
Materias:	CD150 antigen cyclic AMP responsive element binding protein gamma interferon interleukin 17 article cell activation clinical article controlled study human human cell peripheral blood mononuclear cell priority journal protein expression protein phosphorylation protein synthesis T lymphocyte tuberculosis Antigens, CD Cyclic AMP Response Element-Binding Protein Gene Expression Regulation, Bacterial Humans Interferon-gamma Interleukin-17 Phosphorylation Receptors, Cell Surface Tuberculosis
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00221899_v199_n5_p661_Pasquinelli
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_00221899_v199_n5_p661_Pasquinelli
record_format	dspace
spelling	todo:paper_00221899_v199_n5_p661_Pasquinelli2023-10-03T14:28:03Z IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB Pasquinelli, V. Townsend, J.C. Jurado, J.O. Alvarez, I.B. Quiroga, M.F. Barnes, P.F. Samten, B. García, V.E. CD150 antigen cyclic AMP responsive element binding protein gamma interferon interleukin 17 article cell activation clinical article controlled study human human cell peripheral blood mononuclear cell priority journal protein expression protein phosphorylation protein synthesis T lymphocyte tuberculosis Antigens, CD Cyclic AMP Response Element-Binding Protein Gene Expression Regulation, Bacterial Humans Interferon-gamma Interleukin-17 Phosphorylation Receptors, Cell Surface Tuberculosis Interferon-γ (IFN-γ) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-γ transcription. We determined whether the transmembrane receptor signaling lymphocyte activation molecule (SLAM) and interleukin-17 (IL-17) affect CREB phosphorylation and IFN-γ production in persons with tuberculosis. When T cells from patients with tuberculosis were activated with M. tuberculosis, 80% of SLAM+ T cells expressed phosphorylated CREB, and SLAM activation increased CREB phosphorylation and IFN-γ production. In contrast, IL-17 down-regulated SLAM expression, CREB phosphorylation, and IFN-γ production. Therefore, IL-17 and SLAM have opposing effects on IFN-γ production through CREB activation in persons with tuberculosis. © 2009 by the Infectious Diseases Society of America. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00221899_v199_n5_p661_Pasquinelli
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	CD150 antigen cyclic AMP responsive element binding protein gamma interferon interleukin 17 article cell activation clinical article controlled study human human cell peripheral blood mononuclear cell priority journal protein expression protein phosphorylation protein synthesis T lymphocyte tuberculosis Antigens, CD Cyclic AMP Response Element-Binding Protein Gene Expression Regulation, Bacterial Humans Interferon-gamma Interleukin-17 Phosphorylation Receptors, Cell Surface Tuberculosis
spellingShingle	CD150 antigen cyclic AMP responsive element binding protein gamma interferon interleukin 17 article cell activation clinical article controlled study human human cell peripheral blood mononuclear cell priority journal protein expression protein phosphorylation protein synthesis T lymphocyte tuberculosis Antigens, CD Cyclic AMP Response Element-Binding Protein Gene Expression Regulation, Bacterial Humans Interferon-gamma Interleukin-17 Phosphorylation Receptors, Cell Surface Tuberculosis Pasquinelli, V. Townsend, J.C. Jurado, J.O. Alvarez, I.B. Quiroga, M.F. Barnes, P.F. Samten, B. García, V.E. IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
topic_facet	CD150 antigen cyclic AMP responsive element binding protein gamma interferon interleukin 17 article cell activation clinical article controlled study human human cell peripheral blood mononuclear cell priority journal protein expression protein phosphorylation protein synthesis T lymphocyte tuberculosis Antigens, CD Cyclic AMP Response Element-Binding Protein Gene Expression Regulation, Bacterial Humans Interferon-gamma Interleukin-17 Phosphorylation Receptors, Cell Surface Tuberculosis
description	Interferon-γ (IFN-γ) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-γ transcription. We determined whether the transmembrane receptor signaling lymphocyte activation molecule (SLAM) and interleukin-17 (IL-17) affect CREB phosphorylation and IFN-γ production in persons with tuberculosis. When T cells from patients with tuberculosis were activated with M. tuberculosis, 80% of SLAM+ T cells expressed phosphorylated CREB, and SLAM activation increased CREB phosphorylation and IFN-γ production. In contrast, IL-17 down-regulated SLAM expression, CREB phosphorylation, and IFN-γ production. Therefore, IL-17 and SLAM have opposing effects on IFN-γ production through CREB activation in persons with tuberculosis. © 2009 by the Infectious Diseases Society of America. All rights reserved.
format	JOUR
author	Pasquinelli, V. Townsend, J.C. Jurado, J.O. Alvarez, I.B. Quiroga, M.F. Barnes, P.F. Samten, B. García, V.E.
author_facet	Pasquinelli, V. Townsend, J.C. Jurado, J.O. Alvarez, I.B. Quiroga, M.F. Barnes, P.F. Samten, B. García, V.E.
author_sort	Pasquinelli, V.
title	IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
title_short	IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
title_full	IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
title_fullStr	IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
title_full_unstemmed	IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB
title_sort	ifn-γ production during active tuberculosis is regulated by mechanisms that involve il-17, slam, and creb
url	http://hdl.handle.net/20.500.12110/paper_00221899_v199_n5_p661_Pasquinelli
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IFN-γ production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB

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