Galectin-1: A jack-of-all-trades in the resolution of acute and chronic inflammation
Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00221767_v199_n11_p3721_Sundblad |
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todo:paper_00221767_v199_n11_p3721_Sundblad2023-10-03T14:28:01Z Galectin-1: A jack-of-all-trades in the resolution of acute and chronic inflammation Sundblad, V. Morosi, L.G. Geffner, J.R. Rabinovich, G.A. galectin 1 glycan galectin 1 allergy asthma autoimmune diabetes autoimmune disease chronic inflammation diabetes mellitus disease association human immune response immune system immunoregulation immunostimulation infection resistance inflammatory bowel disease molecular biology pathogenesis pregnancy priority journal protein carbohydrate interaction protein expression protein function protein protein interaction resolution associated molecular pattern Review signal transduction tumor immunity acute disease animal cell motion chronic disease female hypersensitivity immunology immunomodulation infection inflammation molecularly targeted therapy neoplasm Acute Disease Animals Autoimmune Diseases Cell Movement Chronic Disease Female Galectin 1 Humans Hypersensitivity Immunomodulation Infection Inflammation Molecular Targeted Therapy Neoplasms Pregnancy Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple immune cell types. Within the innate immune compartment, Gal-1 acts as a resolution-associated molecular pattern by counteracting the synthesis of proinflammatory cytokines, inhibiting neutrophil trafficking, targeting eosinophil migration and survival, and suppressing mast cell degranulation. Likewise, this lectin controls T cell and B cell compartments by modulating receptor clustering and signaling, thus serving as a negative-regulatory checkpoint that reprograms cellular activation, differentiation, and survival. In this review, we discuss the central role of Gal-1 in regulatory programs operating during acute inflammation, autoimmune diseases, allergic inflammation, pregnancy, cancer, and infection. Therapeutic strategies aimed at targeting Gal-1–glycan interactions will contribute to overcome cancer immunosuppression and reinforce antimicrobial immunity, whereas stimulation of Gal-1–driven immunoregulatory circuits will help to mitigate exuberant inflammation. Copyright © 2017 by The American Association of Immunologists, Inc. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00221767_v199_n11_p3721_Sundblad |
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Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
galectin 1 glycan galectin 1 allergy asthma autoimmune diabetes autoimmune disease chronic inflammation diabetes mellitus disease association human immune response immune system immunoregulation immunostimulation infection resistance inflammatory bowel disease molecular biology pathogenesis pregnancy priority journal protein carbohydrate interaction protein expression protein function protein protein interaction resolution associated molecular pattern Review signal transduction tumor immunity acute disease animal cell motion chronic disease female hypersensitivity immunology immunomodulation infection inflammation molecularly targeted therapy neoplasm Acute Disease Animals Autoimmune Diseases Cell Movement Chronic Disease Female Galectin 1 Humans Hypersensitivity Immunomodulation Infection Inflammation Molecular Targeted Therapy Neoplasms Pregnancy |
| spellingShingle |
galectin 1 glycan galectin 1 allergy asthma autoimmune diabetes autoimmune disease chronic inflammation diabetes mellitus disease association human immune response immune system immunoregulation immunostimulation infection resistance inflammatory bowel disease molecular biology pathogenesis pregnancy priority journal protein carbohydrate interaction protein expression protein function protein protein interaction resolution associated molecular pattern Review signal transduction tumor immunity acute disease animal cell motion chronic disease female hypersensitivity immunology immunomodulation infection inflammation molecularly targeted therapy neoplasm Acute Disease Animals Autoimmune Diseases Cell Movement Chronic Disease Female Galectin 1 Humans Hypersensitivity Immunomodulation Infection Inflammation Molecular Targeted Therapy Neoplasms Pregnancy Sundblad, V. Morosi, L.G. Geffner, J.R. Rabinovich, G.A. Galectin-1: A jack-of-all-trades in the resolution of acute and chronic inflammation |
| topic_facet |
galectin 1 glycan galectin 1 allergy asthma autoimmune diabetes autoimmune disease chronic inflammation diabetes mellitus disease association human immune response immune system immunoregulation immunostimulation infection resistance inflammatory bowel disease molecular biology pathogenesis pregnancy priority journal protein carbohydrate interaction protein expression protein function protein protein interaction resolution associated molecular pattern Review signal transduction tumor immunity acute disease animal cell motion chronic disease female hypersensitivity immunology immunomodulation infection inflammation molecularly targeted therapy neoplasm Acute Disease Animals Autoimmune Diseases Cell Movement Chronic Disease Female Galectin 1 Humans Hypersensitivity Immunomodulation Infection Inflammation Molecular Targeted Therapy Neoplasms Pregnancy |
| description |
Regulatory signals provide negative input to immunological networks promoting resolution of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple immune cell types. Within the innate immune compartment, Gal-1 acts as a resolution-associated molecular pattern by counteracting the synthesis of proinflammatory cytokines, inhibiting neutrophil trafficking, targeting eosinophil migration and survival, and suppressing mast cell degranulation. Likewise, this lectin controls T cell and B cell compartments by modulating receptor clustering and signaling, thus serving as a negative-regulatory checkpoint that reprograms cellular activation, differentiation, and survival. In this review, we discuss the central role of Gal-1 in regulatory programs operating during acute inflammation, autoimmune diseases, allergic inflammation, pregnancy, cancer, and infection. Therapeutic strategies aimed at targeting Gal-1–glycan interactions will contribute to overcome cancer immunosuppression and reinforce antimicrobial immunity, whereas stimulation of Gal-1–driven immunoregulatory circuits will help to mitigate exuberant inflammation. Copyright © 2017 by The American Association of Immunologists, Inc. All rights reserved. |
| format |
JOUR |
| author |
Sundblad, V. Morosi, L.G. Geffner, J.R. Rabinovich, G.A. |
| author_facet |
Sundblad, V. Morosi, L.G. Geffner, J.R. Rabinovich, G.A. |
| author_sort |
Sundblad, V. |
| title |
Galectin-1: A jack-of-all-trades in the resolution of acute and chronic inflammation |
| title_short |
Galectin-1: A jack-of-all-trades in the resolution of acute and chronic inflammation |
| title_full |
Galectin-1: A jack-of-all-trades in the resolution of acute and chronic inflammation |
| title_fullStr |
Galectin-1: A jack-of-all-trades in the resolution of acute and chronic inflammation |
| title_full_unstemmed |
Galectin-1: A jack-of-all-trades in the resolution of acute and chronic inflammation |
| title_sort |
galectin-1: a jack-of-all-trades in the resolution of acute and chronic inflammation |
| url |
http://hdl.handle.net/20.500.12110/paper_00221767_v199_n11_p3721_Sundblad |
| work_keys_str_mv |
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