Residual moisture content as related to collapse of freeze-dried sugar matrices

Amorphous sugars were prepared by freeze-drying 20% (w/w) aqueous solutions of lactose, sucrose, trehalose and maltose. The dried samples were further dehydrated over P2O5 for 1 wk at 25, 35 or 45°C, and the residual moisture content was determined using oven drying or a thermogravimetric balance. R...

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Detalles Bibliográficos
Autores principales:	Bonelli, P., Schebor, C., Cukierman, A.L., Buera, M.P., Chirife, J.
Formato:	JOUR
Materias:	Collapse Glass transition Residual moisture Sugars T(g)
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00221147_v62_n4_p693_Bonelli
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00221147_v62_n4_p693_Bonelli2023-10-03T14:27:06Z Residual moisture content as related to collapse of freeze-dried sugar matrices Bonelli, P. Schebor, C. Cukierman, A.L. Buera, M.P. Chirife, J. Collapse Glass transition Residual moisture Sugars T(g) Amorphous sugars were prepared by freeze-drying 20% (w/w) aqueous solutions of lactose, sucrose, trehalose and maltose. The dried samples were further dehydrated over P2O5 for 1 wk at 25, 35 or 45°C, and the residual moisture content was determined using oven drying or a thermogravimetric balance. Results indicated a small amount of residual moisture (usually 1-2%) which was not removed by the desiccation treatment for 1 wk at 25°C over P2O5. The dried samples, heated at a temperature near the published 'anhydrous' glass transition temperatures (T(g)) exhibited different behavior depending on whether they were heated in open or sealed vials. Structural collapse, a sharply visible shrinkage of the matrix, was found in all samples in sealed vials, while those samples in open vials did not collapse. Thus, removal of the last amount of residual moisture by heating in uncovered vials increased T(g), preventing or delaying collapse. Fil:Bonelli, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Schebor, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cukierman, A.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Buera, M.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00221147_v62_n4_p693_Bonelli
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Collapse Glass transition Residual moisture Sugars T(g)
spellingShingle	Collapse Glass transition Residual moisture Sugars T(g) Bonelli, P. Schebor, C. Cukierman, A.L. Buera, M.P. Chirife, J. Residual moisture content as related to collapse of freeze-dried sugar matrices
topic_facet	Collapse Glass transition Residual moisture Sugars T(g)
description	Amorphous sugars were prepared by freeze-drying 20% (w/w) aqueous solutions of lactose, sucrose, trehalose and maltose. The dried samples were further dehydrated over P2O5 for 1 wk at 25, 35 or 45°C, and the residual moisture content was determined using oven drying or a thermogravimetric balance. Results indicated a small amount of residual moisture (usually 1-2%) which was not removed by the desiccation treatment for 1 wk at 25°C over P2O5. The dried samples, heated at a temperature near the published 'anhydrous' glass transition temperatures (T(g)) exhibited different behavior depending on whether they were heated in open or sealed vials. Structural collapse, a sharply visible shrinkage of the matrix, was found in all samples in sealed vials, while those samples in open vials did not collapse. Thus, removal of the last amount of residual moisture by heating in uncovered vials increased T(g), preventing or delaying collapse.
format	JOUR
author	Bonelli, P. Schebor, C. Cukierman, A.L. Buera, M.P. Chirife, J.
author_facet	Bonelli, P. Schebor, C. Cukierman, A.L. Buera, M.P. Chirife, J.
author_sort	Bonelli, P.
title	Residual moisture content as related to collapse of freeze-dried sugar matrices
title_short	Residual moisture content as related to collapse of freeze-dried sugar matrices
title_full	Residual moisture content as related to collapse of freeze-dried sugar matrices
title_fullStr	Residual moisture content as related to collapse of freeze-dried sugar matrices
title_full_unstemmed	Residual moisture content as related to collapse of freeze-dried sugar matrices
title_sort	residual moisture content as related to collapse of freeze-dried sugar matrices
url	http://hdl.handle.net/20.500.12110/paper_00221147_v62_n4_p693_Bonelli
work_keys_str_mv	AT bonellip residualmoisturecontentasrelatedtocollapseoffreezedriedsugarmatrices AT scheborc residualmoisturecontentasrelatedtocollapseoffreezedriedsugarmatrices AT cukiermanal residualmoisturecontentasrelatedtocollapseoffreezedriedsugarmatrices AT bueramp residualmoisturecontentasrelatedtocollapseoffreezedriedsugarmatrices AT chirifej residualmoisturecontentasrelatedtocollapseoffreezedriedsugarmatrices
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Residual moisture content as related to collapse of freeze-dried sugar matrices

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