Kinetoplastids: Related protozoan pathogens, different diseases

Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined difference...

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Autores principales:	Stuart, K., Brun, R., Croft, S., Fairlamb, A., Gürtler, R.E., McKerrow, J., Reed, S., Tarleton, R.
Formato:	JOUR
Materias:	amphotericin B lipid complex benznidazole eflornithine insecticide interleukin 1 interleukin 10 interleukin 12 interleukin 18 Leishmania vaccine meglumine antimonate melarsoprol miltefosine nifurtimox paromomycin pentamidine isethionate stibogluconate sodium suramin toll like receptor 4 toll like receptor 7 toll like receptor 8 toll like receptor 9 transforming growth factor beta Chagas disease continuous infusion flagellate gene sequence genome human infection control Leishmania Leishmania braziliensis Leishmania donovani Leishmania infantum Leishmania major Leishmania mexicana Leishmania tropica leishmaniasis nonhuman patient compliance priority journal protozoon review teratogenicity Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosoma gambiense unspecified side effect Animals Antiprotozoal Agents Genetic Vectors Genome, Protozoan Humans Kinetoplastida Mastigophora Infections Protozoan Vaccines
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00219738_v118_n4_p1301_Stuart
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_00219738_v118_n4_p1301_Stuart2023-10-03T14:25:06Z Kinetoplastids: Related protozoan pathogens, different diseases Stuart, K. Brun, R. Croft, S. Fairlamb, A. Gürtler, R.E. McKerrow, J. Reed, S. Tarleton, R. amphotericin B lipid complex benznidazole eflornithine insecticide interleukin 1 interleukin 10 interleukin 12 interleukin 18 Leishmania vaccine meglumine antimonate melarsoprol miltefosine nifurtimox paromomycin pentamidine isethionate stibogluconate sodium suramin toll like receptor 4 toll like receptor 7 toll like receptor 8 toll like receptor 9 transforming growth factor beta Chagas disease continuous infusion flagellate gene sequence genome human infection control Leishmania Leishmania braziliensis Leishmania donovani Leishmania infantum Leishmania major Leishmania mexicana Leishmania tropica leishmaniasis nonhuman patient compliance priority journal protozoon review teratogenicity Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosoma gambiense unspecified side effect Animals Antiprotozoal Agents Genetic Vectors Genome, Protozoan Humans Kinetoplastida Mastigophora Infections Protozoan Vaccines Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined differences in the diseases that they cause. As we discuss in this Review, steady progress using a combination of molecular, genetic, immunologic, and clinical approaches has substantially increased understanding of these pathogens and important aspects of the diseases that they cause. Consequently, the paths for developing additional measures to control these "neglected diseases" are becoming increasingly clear, and we believe that the opportunities for developing the drugs, diagnostics, vaccines, and other tools necessary to expand the armamentarium to combat these diseases have never been better. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00219738_v118_n4_p1301_Stuart
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	amphotericin B lipid complex benznidazole eflornithine insecticide interleukin 1 interleukin 10 interleukin 12 interleukin 18 Leishmania vaccine meglumine antimonate melarsoprol miltefosine nifurtimox paromomycin pentamidine isethionate stibogluconate sodium suramin toll like receptor 4 toll like receptor 7 toll like receptor 8 toll like receptor 9 transforming growth factor beta Chagas disease continuous infusion flagellate gene sequence genome human infection control Leishmania Leishmania braziliensis Leishmania donovani Leishmania infantum Leishmania major Leishmania mexicana Leishmania tropica leishmaniasis nonhuman patient compliance priority journal protozoon review teratogenicity Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosoma gambiense unspecified side effect Animals Antiprotozoal Agents Genetic Vectors Genome, Protozoan Humans Kinetoplastida Mastigophora Infections Protozoan Vaccines
spellingShingle	amphotericin B lipid complex benznidazole eflornithine insecticide interleukin 1 interleukin 10 interleukin 12 interleukin 18 Leishmania vaccine meglumine antimonate melarsoprol miltefosine nifurtimox paromomycin pentamidine isethionate stibogluconate sodium suramin toll like receptor 4 toll like receptor 7 toll like receptor 8 toll like receptor 9 transforming growth factor beta Chagas disease continuous infusion flagellate gene sequence genome human infection control Leishmania Leishmania braziliensis Leishmania donovani Leishmania infantum Leishmania major Leishmania mexicana Leishmania tropica leishmaniasis nonhuman patient compliance priority journal protozoon review teratogenicity Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosoma gambiense unspecified side effect Animals Antiprotozoal Agents Genetic Vectors Genome, Protozoan Humans Kinetoplastida Mastigophora Infections Protozoan Vaccines Stuart, K. Brun, R. Croft, S. Fairlamb, A. Gürtler, R.E. McKerrow, J. Reed, S. Tarleton, R. Kinetoplastids: Related protozoan pathogens, different diseases
topic_facet	amphotericin B lipid complex benznidazole eflornithine insecticide interleukin 1 interleukin 10 interleukin 12 interleukin 18 Leishmania vaccine meglumine antimonate melarsoprol miltefosine nifurtimox paromomycin pentamidine isethionate stibogluconate sodium suramin toll like receptor 4 toll like receptor 7 toll like receptor 8 toll like receptor 9 transforming growth factor beta Chagas disease continuous infusion flagellate gene sequence genome human infection control Leishmania Leishmania braziliensis Leishmania donovani Leishmania infantum Leishmania major Leishmania mexicana Leishmania tropica leishmaniasis nonhuman patient compliance priority journal protozoon review teratogenicity Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosoma gambiense unspecified side effect Animals Antiprotozoal Agents Genetic Vectors Genome, Protozoan Humans Kinetoplastida Mastigophora Infections Protozoan Vaccines
description	Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined differences in the diseases that they cause. As we discuss in this Review, steady progress using a combination of molecular, genetic, immunologic, and clinical approaches has substantially increased understanding of these pathogens and important aspects of the diseases that they cause. Consequently, the paths for developing additional measures to control these "neglected diseases" are becoming increasingly clear, and we believe that the opportunities for developing the drugs, diagnostics, vaccines, and other tools necessary to expand the armamentarium to combat these diseases have never been better.
format	JOUR
author	Stuart, K. Brun, R. Croft, S. Fairlamb, A. Gürtler, R.E. McKerrow, J. Reed, S. Tarleton, R.
author_facet	Stuart, K. Brun, R. Croft, S. Fairlamb, A. Gürtler, R.E. McKerrow, J. Reed, S. Tarleton, R.
author_sort	Stuart, K.
title	Kinetoplastids: Related protozoan pathogens, different diseases
title_short	Kinetoplastids: Related protozoan pathogens, different diseases
title_full	Kinetoplastids: Related protozoan pathogens, different diseases
title_fullStr	Kinetoplastids: Related protozoan pathogens, different diseases
title_full_unstemmed	Kinetoplastids: Related protozoan pathogens, different diseases
title_sort	kinetoplastids: related protozoan pathogens, different diseases
url	http://hdl.handle.net/20.500.12110/paper_00219738_v118_n4_p1301_Stuart
work_keys_str_mv	AT stuartk kinetoplastidsrelatedprotozoanpathogensdifferentdiseases AT brunr kinetoplastidsrelatedprotozoanpathogensdifferentdiseases AT crofts kinetoplastidsrelatedprotozoanpathogensdifferentdiseases AT fairlamba kinetoplastidsrelatedprotozoanpathogensdifferentdiseases AT gurtlerre kinetoplastidsrelatedprotozoanpathogensdifferentdiseases AT mckerrowj kinetoplastidsrelatedprotozoanpathogensdifferentdiseases AT reeds kinetoplastidsrelatedprotozoanpathogensdifferentdiseases AT tarletonr kinetoplastidsrelatedprotozoanpathogensdifferentdiseases
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Kinetoplastids: Related protozoan pathogens, different diseases

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