Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface
Among the biologically required first row, late d-block metals from MnII to ZnII, the catalytic and structural reach of ZnII ensures that this essential micronutrient touches nearly every major metabolic process or pathway in the cell. Zn is also toxic in excess, primarily because it is a highly com...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00219258_v291_n40_p20858_Capdevila |
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todo:paper_00219258_v291_n40_p20858_Capdevila2023-10-03T14:23:25Z Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface Capdevila, D.A. Wang, J. Giedroc, D.P. Manganese Pathogens Structural metals Transition metals Zinc Achilles heel Bacterial evolution Divalent metals Hostile environments Innate immune systems Metabolic process Metalloenzymes Microbial physiology Metals bacillithiol cyanocobalamin glutathione reactive oxygen metabolite RNA polymerase siderophore thiol derivative unclassified drug zinc ion zinc Acinetobacter baumannii allostasis allosterism Bacillus subtilis bacterial outer membrane bacterial strain bioavailability carboxy terminal sequence cation transport cytoplasm DNA binding Escherichia coli host pathogen interaction hydrolysis in vivo study molecular recognition Mycobacterium tuberculosis nonhuman priority journal Salmonella enterica Shigella sonnei Short Survey Staphylococcus aureus Streptococcus pneumoniae Streptomyces coelicolor transcription regulation zinc efflux zinc homeostasis zinc metallostasis zinc uptake animal bacterial phenomena and functions bacterium host pathogen interaction human metabolism physiology Animals Bacteria Bacterial Physiological Phenomena Host-Pathogen Interactions Humans Zinc Among the biologically required first row, late d-block metals from MnII to ZnII, the catalytic and structural reach of ZnII ensures that this essential micronutrient touches nearly every major metabolic process or pathway in the cell. Zn is also toxic in excess, primarily because it is a highly competitive divalent metal and will displace more weakly bound transition metals in the active sites of metalloenzymes if left unregulated. The vertebrate innate immune system uses several strategies to exploit this "Achilles heel" of microbial physiology, but bacterial evolution has responded in kind. This review highlights recent insights into transcriptional, transport, and trafficking mechanisms that pathogens use to "win the fight" over zinc and thrive in an otherwise hostile environment. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc. Fil:Capdevila, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00219258_v291_n40_p20858_Capdevila |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Manganese Pathogens Structural metals Transition metals Zinc Achilles heel Bacterial evolution Divalent metals Hostile environments Innate immune systems Metabolic process Metalloenzymes Microbial physiology Metals bacillithiol cyanocobalamin glutathione reactive oxygen metabolite RNA polymerase siderophore thiol derivative unclassified drug zinc ion zinc Acinetobacter baumannii allostasis allosterism Bacillus subtilis bacterial outer membrane bacterial strain bioavailability carboxy terminal sequence cation transport cytoplasm DNA binding Escherichia coli host pathogen interaction hydrolysis in vivo study molecular recognition Mycobacterium tuberculosis nonhuman priority journal Salmonella enterica Shigella sonnei Short Survey Staphylococcus aureus Streptococcus pneumoniae Streptomyces coelicolor transcription regulation zinc efflux zinc homeostasis zinc metallostasis zinc uptake animal bacterial phenomena and functions bacterium host pathogen interaction human metabolism physiology Animals Bacteria Bacterial Physiological Phenomena Host-Pathogen Interactions Humans Zinc |
| spellingShingle |
Manganese Pathogens Structural metals Transition metals Zinc Achilles heel Bacterial evolution Divalent metals Hostile environments Innate immune systems Metabolic process Metalloenzymes Microbial physiology Metals bacillithiol cyanocobalamin glutathione reactive oxygen metabolite RNA polymerase siderophore thiol derivative unclassified drug zinc ion zinc Acinetobacter baumannii allostasis allosterism Bacillus subtilis bacterial outer membrane bacterial strain bioavailability carboxy terminal sequence cation transport cytoplasm DNA binding Escherichia coli host pathogen interaction hydrolysis in vivo study molecular recognition Mycobacterium tuberculosis nonhuman priority journal Salmonella enterica Shigella sonnei Short Survey Staphylococcus aureus Streptococcus pneumoniae Streptomyces coelicolor transcription regulation zinc efflux zinc homeostasis zinc metallostasis zinc uptake animal bacterial phenomena and functions bacterium host pathogen interaction human metabolism physiology Animals Bacteria Bacterial Physiological Phenomena Host-Pathogen Interactions Humans Zinc Capdevila, D.A. Wang, J. Giedroc, D.P. Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface |
| topic_facet |
Manganese Pathogens Structural metals Transition metals Zinc Achilles heel Bacterial evolution Divalent metals Hostile environments Innate immune systems Metabolic process Metalloenzymes Microbial physiology Metals bacillithiol cyanocobalamin glutathione reactive oxygen metabolite RNA polymerase siderophore thiol derivative unclassified drug zinc ion zinc Acinetobacter baumannii allostasis allosterism Bacillus subtilis bacterial outer membrane bacterial strain bioavailability carboxy terminal sequence cation transport cytoplasm DNA binding Escherichia coli host pathogen interaction hydrolysis in vivo study molecular recognition Mycobacterium tuberculosis nonhuman priority journal Salmonella enterica Shigella sonnei Short Survey Staphylococcus aureus Streptococcus pneumoniae Streptomyces coelicolor transcription regulation zinc efflux zinc homeostasis zinc metallostasis zinc uptake animal bacterial phenomena and functions bacterium host pathogen interaction human metabolism physiology Animals Bacteria Bacterial Physiological Phenomena Host-Pathogen Interactions Humans Zinc |
| description |
Among the biologically required first row, late d-block metals from MnII to ZnII, the catalytic and structural reach of ZnII ensures that this essential micronutrient touches nearly every major metabolic process or pathway in the cell. Zn is also toxic in excess, primarily because it is a highly competitive divalent metal and will displace more weakly bound transition metals in the active sites of metalloenzymes if left unregulated. The vertebrate innate immune system uses several strategies to exploit this "Achilles heel" of microbial physiology, but bacterial evolution has responded in kind. This review highlights recent insights into transcriptional, transport, and trafficking mechanisms that pathogens use to "win the fight" over zinc and thrive in an otherwise hostile environment. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc. |
| format |
JOUR |
| author |
Capdevila, D.A. Wang, J. Giedroc, D.P. |
| author_facet |
Capdevila, D.A. Wang, J. Giedroc, D.P. |
| author_sort |
Capdevila, D.A. |
| title |
Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface |
| title_short |
Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface |
| title_full |
Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface |
| title_fullStr |
Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface |
| title_full_unstemmed |
Bacterial strategies to maintain zinc metallostasis at the host-pathogen interface |
| title_sort |
bacterial strategies to maintain zinc metallostasis at the host-pathogen interface |
| url |
http://hdl.handle.net/20.500.12110/paper_00219258_v291_n40_p20858_Capdevila |
| work_keys_str_mv |
AT capdevilada bacterialstrategiestomaintainzincmetallostasisatthehostpathogeninterface AT wangj bacterialstrategiestomaintainzincmetallostasisatthehostpathogeninterface AT giedrocdp bacterialstrategiestomaintainzincmetallostasisatthehostpathogeninterface |
| _version_ |
1807322390207660032 |