Hypothyroid phenotype is contributed by mitochondrial complex I inactivation due to translocated neuronal nitric-oxide synthase

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Although transcriptional effects of thyroid hormones have substantial influence on oxidative metabolism, how thyroid sets basal metabolic rate remains obscure. Compartmental localization of nitric-oxide synthases is important for nitric oxide signaling. We therefore examined liver neuronal nitric-ox...

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Autores principales:	Franco, M.C., Antico Arciuch, V.G., Peralta, J.G., Galli, S., Levisman, D., López, L.M., Romorini, L., Poderoso, J.J., Carreras, M.C.
Formato:	JOUR
Materias:	Complexation Hormones Metabolism Neurology Oxides Proteins RNA Hypothyroid Mitochondria Mitochondrial complex I Neuronal nitric-oxide synthase Nitric acid 3,3',5' triiodothyronine cyclin D1 liver enzyme messenger RNA mitochondrial complex 1 mitogen activated protein kinase 1 mitogen activated protein kinase 3 mitogen activated protein kinase p38 n(g) nitroarginine methyl ester neuronal nitric oxide synthase neuronal nitric oxide synthase alpha nitric oxide oxidoreductase peroxynitrite reactive oxygen metabolite reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) thiamazole thyrotropin tyrosine unclassified drug heat shock protein 90 isoprotein nitric oxide synthase oxidizing agent oxygen peroxynitrous acid thyroid hormone animal cell animal experiment animal tissue article basal metabolic rate cell communication cellular distribution controlled study enzyme activity enzyme inactivation enzyme localization hypothyroidism liothyronine blood level male mitochondrial respiration nitration nonhuman oxygen consumption phenotype priority journal protein expression protein transport rat signal transduction animal cell fractionation chemical model chemistry cytosol electron enzymology genetic transcription immunoblotting immunoelectron microscopy immunoprecipitation liver liver mitochondrion metabolism mitochondrion pathology polyacrylamide gel electrophoresis reverse transcription polymerase chain reaction Wistar rat Animals Cyclin D1 Cytosol Electron Transport Complex I Electrons Electrophoresis, Polyacrylamide Gel HSP90 Heat-Shock Proteins Hypothyroidism Immunoblotting Immunoprecipitation Liver Male MAP Kinase Signaling System Microscopy, Immunoelectron Mitochondria, Liver Models, Chemical NG-Nitroarginine Methyl Ester Nitric Oxide Synthase Nitric Oxide Synthase Type I Oxidants Oxygen p38 Mitogen-Activated Protein Kinases Peroxynitrous Acid Phenotype Protein Isoforms Protein Transport Rats Rats, Wistar Reactive Oxygen Species Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger Signal Transduction Subcellular Fractions Thyroid Hormones Transcription, Genetic
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00219258_v281_n8_p4779_Franco
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires