Glucocorticoids repress bcl-X expression in lymphoid cells by recruiting STAT5B to the P4 promoter

Mostrar todas las versiones(3)

The bcl-X gene plays a critical role in apoptosis. Six different isoforms generated by tissue-specific promoter usage and alternative splicing were described. Some of them exert opposite effects on cell death. In mammary epithelial cells glucocorticoids induce bcl-X expression and increase the ratio...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Rocha-Viegas, L., Vicent, G.P., Barañao, J.L., Beato, M., Pecci, A.
Formato: JOUR
Materias:
Derivatives
Enzyme inhibition
Genes
Hormones
RNA
Tissue
Cell death
Hormonal treatment
Lymphoid cells
Thymocytes
Cells
dexamethasone
glucocorticoid
glucocorticoid receptor
histone deacetylase 3
histone H3
protein bcl x
retinoic acid receptor
RNA polymerase II
STAT5b protein
steroid receptor coactivator 1
thyroid hormone receptor
acetylation
animal cell
animal experiment
article
controlled study
gene activity
gene expression
gene silencing
hormone inhibition
lymphoid cell
male
mouse
nonhuman
priority journal
promoter region
protein DNA binding
protein DNA interaction
T lymphocyte
thymocyte
transcription regulation
Acetylation
Animals
Apoptosis
bcl-X Protein
Cercopithecus aethiops
Chromatin Immunoprecipitation
COS Cells
Dexamethasone
Electrophoretic Mobility Shift Assay
Gene Expression Regulation
Histone Acetyltransferases
Histones
Hormone Antagonists
Lymphocytes
Male
Mice
Mifepristone
Plasmids
Promoter Regions (Genetics)
Receptors, Glucocorticoid
Reverse Transcriptase Polymerase Chain Reaction
RNA Polymerase II
RNA, Messenger
STAT5 Transcription Factor
Thymus Gland
Transcription Factors
Transcription, Genetic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00219258_v281_n45_p33959_RochaViegas
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares