Lethal and Sublethal Effects of Withanolides from Salpichroa origanifolia and Analogues on Ceratitis capitata

Biological effects on Ceratitis capitata were evaluated for several withanolides isolated from Salpichroa origanifolia (Solanaceae), (20S,22R,24S,25S,26R)-5α,6α:22,26:24, 25-triepoxy-26-hydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide A, 1), (20S,22R,24S,25S,26R)-22,26:24,25-di...

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Detalles Bibliográficos
Autores principales: Bado, S., Mareggiani, G., Amiano, N., Burton, G., Veleiro, A.S.
Formato: JOUR
Materias:
Ceratitis capitata
Natural insecticides
Saipichroa origanifolla
Withanolides
drinking water
salpichrolide a
salpichrolide b
salpichrolide c
salpichrolide g
unclassified drug
withanolide
angiosperm
article
chemical analysis
chemical modification
chemical structure
diet
fruit development
larva
lethality
Mediterranean fruit fly
mortality
nonhuman
Epoxy Compounds
Ergosterol
Insecticides
Solanaceae
Capitata
Ceratitis
Drosophila melanogaster
Magnoliophyta
Salpichroa origanifolia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00218561_v52_n10_p2875_Bado
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_00218561_v52_n10_p2875_Bado2023-10-03T14:21:03Z Lethal and Sublethal Effects of Withanolides from Salpichroa origanifolia and Analogues on Ceratitis capitata Bado, S. Mareggiani, G. Amiano, N. Burton, G. Veleiro, A.S. Ceratitis capitata Natural insecticides Saipichroa origanifolla Withanolides drinking water salpichrolide a salpichrolide b salpichrolide c salpichrolide g unclassified drug withanolide angiosperm article chemical analysis chemical modification chemical structure diet fruit development larva lethality Mediterranean fruit fly mortality nonhuman Ceratitis capitata Epoxy Compounds Ergosterol Insecticides Solanaceae Capitata Ceratitis Ceratitis capitata Drosophila melanogaster Magnoliophyta Salpichroa origanifolia Solanaceae Biological effects on Ceratitis capitata were evaluated for several withanolides isolated from Salpichroa origanifolia (Solanaceae), (20S,22R,24S,25S,26R)-5α,6α:22,26:24, 25-triepoxy-26-hydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide A, 1), (20S,22R,24S,25S,26R)-22,26:24,25-diepoxy-5α,6β ,26-trihydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide C, 2), (20S,22R,24S,25S,26R)-5α,6α; 22,26:24,25-triepoxy-15,26-dihydroxy-17(13→18)abeo-ergosta-2,13,15, 17-tetraen-1-one (salpichrolide G, 3), and (20S,22R,24S,25S,26R)-5α ,6α:22,26:24,25-triepoxy-1,26-dihydroxy-17(13→18)-abeo-ergosta-2,13, 15,17-tetraene (salpichrolide B, 5), and for chemically modified analogues. Influence of chemical modifications on development delay was analyzed. The compounds were incorporated into the larval diet and the adults' drinking water. Significant development delays from larvae to puparia were observed in treatments with the natural withanolides salpichrolides A, C, and G (1-3) at a concentration of 500 ppm. Salpichrolide B (5) was the most toxic compound, the highest mortality (95%) being observed at the larval stage. Exposure of adults to drinking water containing natural withanolides 1-3 and 5 produced mortality in all cases. Fil:Bado, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Mareggiani, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Amiano, N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Veleiro, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_00218561_v52_n10_p2875_Bado
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Ceratitis capitata
Natural insecticides
Saipichroa origanifolla
Withanolides
drinking water
salpichrolide a
salpichrolide b
salpichrolide c
salpichrolide g
unclassified drug
withanolide
angiosperm
article
chemical analysis
chemical modification
chemical structure
diet
fruit development
larva
lethality
Mediterranean fruit fly
mortality
nonhuman
Ceratitis capitata
Epoxy Compounds
Ergosterol
Insecticides
Solanaceae
Capitata
Ceratitis
Ceratitis capitata
Drosophila melanogaster
Magnoliophyta
Salpichroa origanifolia
Solanaceae
spellingShingle Ceratitis capitata
Natural insecticides
Saipichroa origanifolla
Withanolides
drinking water
salpichrolide a
salpichrolide b
salpichrolide c
salpichrolide g
unclassified drug
withanolide
angiosperm
article
chemical analysis
chemical modification
chemical structure
diet
fruit development
larva
lethality
Mediterranean fruit fly
mortality
nonhuman
Ceratitis capitata
Epoxy Compounds
Ergosterol
Insecticides
Solanaceae
Capitata
Ceratitis
Ceratitis capitata
Drosophila melanogaster
Magnoliophyta
Salpichroa origanifolia
Solanaceae
Bado, S.
Mareggiani, G.
Amiano, N.
Burton, G.
Veleiro, A.S.
Lethal and Sublethal Effects of Withanolides from Salpichroa origanifolia and Analogues on Ceratitis capitata
topic_facet Ceratitis capitata
Natural insecticides
Saipichroa origanifolla
Withanolides
drinking water
salpichrolide a
salpichrolide b
salpichrolide c
salpichrolide g
unclassified drug
withanolide
angiosperm
article
chemical analysis
chemical modification
chemical structure
diet
fruit development
larva
lethality
Mediterranean fruit fly
mortality
nonhuman
Ceratitis capitata
Epoxy Compounds
Ergosterol
Insecticides
Solanaceae
Capitata
Ceratitis
Ceratitis capitata
Drosophila melanogaster
Magnoliophyta
Salpichroa origanifolia
Solanaceae
description Biological effects on Ceratitis capitata were evaluated for several withanolides isolated from Salpichroa origanifolia (Solanaceae), (20S,22R,24S,25S,26R)-5α,6α:22,26:24, 25-triepoxy-26-hydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide A, 1), (20S,22R,24S,25S,26R)-22,26:24,25-diepoxy-5α,6β ,26-trihydroxy-17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide C, 2), (20S,22R,24S,25S,26R)-5α,6α; 22,26:24,25-triepoxy-15,26-dihydroxy-17(13→18)abeo-ergosta-2,13,15, 17-tetraen-1-one (salpichrolide G, 3), and (20S,22R,24S,25S,26R)-5α ,6α:22,26:24,25-triepoxy-1,26-dihydroxy-17(13→18)-abeo-ergosta-2,13, 15,17-tetraene (salpichrolide B, 5), and for chemically modified analogues. Influence of chemical modifications on development delay was analyzed. The compounds were incorporated into the larval diet and the adults' drinking water. Significant development delays from larvae to puparia were observed in treatments with the natural withanolides salpichrolides A, C, and G (1-3) at a concentration of 500 ppm. Salpichrolide B (5) was the most toxic compound, the highest mortality (95%) being observed at the larval stage. Exposure of adults to drinking water containing natural withanolides 1-3 and 5 produced mortality in all cases.
format JOUR
author Bado, S.
Mareggiani, G.
Amiano, N.
Burton, G.
Veleiro, A.S.
author_facet Bado, S.
Mareggiani, G.
Amiano, N.
Burton, G.
Veleiro, A.S.
author_sort Bado, S.
title Lethal and Sublethal Effects of Withanolides from Salpichroa origanifolia and Analogues on Ceratitis capitata
title_short Lethal and Sublethal Effects of Withanolides from Salpichroa origanifolia and Analogues on Ceratitis capitata
title_full Lethal and Sublethal Effects of Withanolides from Salpichroa origanifolia and Analogues on Ceratitis capitata
title_fullStr Lethal and Sublethal Effects of Withanolides from Salpichroa origanifolia and Analogues on Ceratitis capitata
title_full_unstemmed Lethal and Sublethal Effects of Withanolides from Salpichroa origanifolia and Analogues on Ceratitis capitata
title_sort lethal and sublethal effects of withanolides from salpichroa origanifolia and analogues on ceratitis capitata
url http://hdl.handle.net/20.500.12110/paper_00218561_v52_n10_p2875_Bado
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