Contractile characteristics of fimbrial, isthmic, ampullar, and fimbrio-ampullar segments of isolated sow (Sus scrofa) oviduct as influenced by ovulation, adrenergic mechanisms, and prostaglandin E 1

Spontaneous contractile characteristics as well as inotropic influences of norepinephrine (NE) and prostaglandin E 1 (PGE 1) on different sow oviductal segments isolated from preovulatory or early postovulatory period, were explored. Postovulatory fimbrial preparations contracted with higher intensi...

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Autores principales: Borda, E.S., Speziale, N.B., Borda, L.J., Gimeno, M.F., Gimeno, A.L.
Formato: JOUR
Materias:
adrenergic receptor
noradrenalin
phentolamine
phentolamine mesylate
prostaglandin e1
animal experiment
drug efficacy
endocrine system
female genital system
in vitro study
ovulation
smooth muscle contractility
swine
uterine tube
Animals
Fallopian Tubes
Female
Norepinephrine
Ovulation
Phentolamine
Prostaglandins E, Synthetic
Swine
Time Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0020725X_v25_n1_p28_Borda
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_0020725X_v25_n1_p28_Borda
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spelling todo:paper_0020725X_v25_n1_p28_Borda2023-10-03T14:18:31Z Contractile characteristics of fimbrial, isthmic, ampullar, and fimbrio-ampullar segments of isolated sow (Sus scrofa) oviduct as influenced by ovulation, adrenergic mechanisms, and prostaglandin E 1 Borda, E.S. Speziale, N.B. Borda, L.J. Gimeno, M.F. Gimeno, A.L. adrenergic receptor noradrenalin phentolamine phentolamine mesylate prostaglandin e1 animal experiment drug efficacy endocrine system female genital system in vitro study ovulation smooth muscle contractility swine uterine tube Animals Fallopian Tubes Female Norepinephrine Ovulation Phentolamine Prostaglandins E, Synthetic Swine Time Factors Spontaneous contractile characteristics as well as inotropic influences of norepinephrine (NE) and prostaglandin E 1 (PGE 1) on different sow oviductal segments isolated from preovulatory or early postovulatory period, were explored. Postovulatory fimbrial preparations contracted with higher intensity and slower frequency the preovulatory ones whereas the spontaneous motility of other regions were comparable at both stages. Norepinephrine (NE) depressed preovulatory ampullar and fimbrio-ampullar portions but stimulated fimbrial and isthmic segments. However, after ovulation NE enhanced the motility of all tubal regions, particularly the fimbrial ones. Phentolamine abolished and even reversed, on postovulatory ampulla, the contractile augmentation elicited by NE. PGE 1 markedly diminished the tension and frequency of preovulatory fimbrial and fimbrio-ampullar segments but it was inactive on other ampullar regions. This depressant influence on the preovulatory fimbrio-ampullar region was replaced, a few hours following ovulation, by a distinct contractile increment. Although phentolamine failed to alter the PGE 1 postovulatory ampullar influences, it clearly blunted the PGE 1 enhancement of postovulatory isthmic motility. The results suggest that changes observed in adrenergic or prostaglandin responses of the sow oviduct may be linked in influences exerted by rapid variations of circulating substances associated with the ovulatory process. Furthermore it is also plausible that the actions of PGE 1 on the isthmus but not on the ampulla is indirect and attributable, at least in part, to the release of NE. It finally appears that the fimbrio-ampullar junction of the domestic sow acts as a 'prostaglandin sphincter' able to avoid the loss of oocytes newly introduced into the oviduct. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0020725X_v25_n1_p28_Borda
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic adrenergic receptor
noradrenalin
phentolamine
phentolamine mesylate
prostaglandin e1
animal experiment
drug efficacy
endocrine system
female genital system
in vitro study
ovulation
smooth muscle contractility
swine
uterine tube
Animals
Fallopian Tubes
Female
Norepinephrine
Ovulation
Phentolamine
Prostaglandins E, Synthetic
Swine
Time Factors
spellingShingle adrenergic receptor
noradrenalin
phentolamine
phentolamine mesylate
prostaglandin e1
animal experiment
drug efficacy
endocrine system
female genital system
in vitro study
ovulation
smooth muscle contractility
swine
uterine tube
Animals
Fallopian Tubes
Female
Norepinephrine
Ovulation
Phentolamine
Prostaglandins E, Synthetic
Swine
Time Factors
Borda, E.S.
Speziale, N.B.
Borda, L.J.
Gimeno, M.F.
Gimeno, A.L.
Contractile characteristics of fimbrial, isthmic, ampullar, and fimbrio-ampullar segments of isolated sow (Sus scrofa) oviduct as influenced by ovulation, adrenergic mechanisms, and prostaglandin E 1
topic_facet adrenergic receptor
noradrenalin
phentolamine
phentolamine mesylate
prostaglandin e1
animal experiment
drug efficacy
endocrine system
female genital system
in vitro study
ovulation
smooth muscle contractility
swine
uterine tube
Animals
Fallopian Tubes
Female
Norepinephrine
Ovulation
Phentolamine
Prostaglandins E, Synthetic
Swine
Time Factors
description Spontaneous contractile characteristics as well as inotropic influences of norepinephrine (NE) and prostaglandin E 1 (PGE 1) on different sow oviductal segments isolated from preovulatory or early postovulatory period, were explored. Postovulatory fimbrial preparations contracted with higher intensity and slower frequency the preovulatory ones whereas the spontaneous motility of other regions were comparable at both stages. Norepinephrine (NE) depressed preovulatory ampullar and fimbrio-ampullar portions but stimulated fimbrial and isthmic segments. However, after ovulation NE enhanced the motility of all tubal regions, particularly the fimbrial ones. Phentolamine abolished and even reversed, on postovulatory ampulla, the contractile augmentation elicited by NE. PGE 1 markedly diminished the tension and frequency of preovulatory fimbrial and fimbrio-ampullar segments but it was inactive on other ampullar regions. This depressant influence on the preovulatory fimbrio-ampullar region was replaced, a few hours following ovulation, by a distinct contractile increment. Although phentolamine failed to alter the PGE 1 postovulatory ampullar influences, it clearly blunted the PGE 1 enhancement of postovulatory isthmic motility. The results suggest that changes observed in adrenergic or prostaglandin responses of the sow oviduct may be linked in influences exerted by rapid variations of circulating substances associated with the ovulatory process. Furthermore it is also plausible that the actions of PGE 1 on the isthmus but not on the ampulla is indirect and attributable, at least in part, to the release of NE. It finally appears that the fimbrio-ampullar junction of the domestic sow acts as a 'prostaglandin sphincter' able to avoid the loss of oocytes newly introduced into the oviduct.
format JOUR
author Borda, E.S.
Speziale, N.B.
Borda, L.J.
Gimeno, M.F.
Gimeno, A.L.
author_facet Borda, E.S.
Speziale, N.B.
Borda, L.J.
Gimeno, M.F.
Gimeno, A.L.
author_sort Borda, E.S.
title Contractile characteristics of fimbrial, isthmic, ampullar, and fimbrio-ampullar segments of isolated sow (Sus scrofa) oviduct as influenced by ovulation, adrenergic mechanisms, and prostaglandin E 1
title_short Contractile characteristics of fimbrial, isthmic, ampullar, and fimbrio-ampullar segments of isolated sow (Sus scrofa) oviduct as influenced by ovulation, adrenergic mechanisms, and prostaglandin E 1
title_full Contractile characteristics of fimbrial, isthmic, ampullar, and fimbrio-ampullar segments of isolated sow (Sus scrofa) oviduct as influenced by ovulation, adrenergic mechanisms, and prostaglandin E 1
title_fullStr Contractile characteristics of fimbrial, isthmic, ampullar, and fimbrio-ampullar segments of isolated sow (Sus scrofa) oviduct as influenced by ovulation, adrenergic mechanisms, and prostaglandin E 1
title_full_unstemmed Contractile characteristics of fimbrial, isthmic, ampullar, and fimbrio-ampullar segments of isolated sow (Sus scrofa) oviduct as influenced by ovulation, adrenergic mechanisms, and prostaglandin E 1
title_sort contractile characteristics of fimbrial, isthmic, ampullar, and fimbrio-ampullar segments of isolated sow (sus scrofa) oviduct as influenced by ovulation, adrenergic mechanisms, and prostaglandin e 1
url http://hdl.handle.net/20.500.12110/paper_0020725X_v25_n1_p28_Borda
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AT spezialenb contractilecharacteristicsoffimbrialisthmicampullarandfimbrioampullarsegmentsofisolatedsowsusscrofaoviductasinfluencedbyovulationadrenergicmechanismsandprostaglandine1
AT bordalj contractilecharacteristicsoffimbrialisthmicampullarandfimbrioampullarsegmentsofisolatedsowsusscrofaoviductasinfluencedbyovulationadrenergicmechanismsandprostaglandine1
AT gimenomf contractilecharacteristicsoffimbrialisthmicampullarandfimbrioampullarsegmentsofisolatedsowsusscrofaoviductasinfluencedbyovulationadrenergicmechanismsandprostaglandine1
AT gimenoal contractilecharacteristicsoffimbrialisthmicampullarandfimbrioampullarsegmentsofisolatedsowsusscrofaoviductasinfluencedbyovulationadrenergicmechanismsandprostaglandine1
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